Gq - ADGRE1 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 780 5x65 G.H5 L 349 G.H5.16
Polar TM3 M 693 3x57 G.H5 Y 356 G.H5.23
Hydrophobic TM3 M 693 3x57 G.H5 Y 356 G.H5.23
Van-der-waals TM3 M 693 3x57 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 N 701 - G.hns1 R 37 G.hns1.02
Polar TM6 K 799 6x41 G.H5 V 359 G.H5.26
Hydrophobic TM6 K 799 6x41 G.H5 V 359 G.H5.26
Van-der-waals TM6 K 799 6x41 G.H5 V 359 G.H5.26
Polar ICL2 S 704 - G.HN K 33 G.HN.51
Hydrophobic ICL3 T 789 - G.S6 Y 325 G.S6.02
Hydrophobic ICL2 L 697 - G.H5 Y 356 G.H5.23
Polar ICL3 S 788 - G.H5 D 346 G.H5.13
Hydrophobic ICL3 S 788 - G.H5 D 346 G.H5.13
Van-der-waals ICL3 S 788 - G.H5 D 346 G.H5.13
Polar TM7 H 844 7x57 G.H5 N 357 G.H5.24
Van-der-waals TM7 H 844 7x57 G.H5 N 357 G.H5.24
Polar ICL2 L 697 - G.H5 N 352 G.H5.19
Hydrophobic ICL2 L 697 - G.H5 N 352 G.H5.19
Van-der-waals ICL2 L 697 - G.H5 N 352 G.H5.19
Hydrophobic ICL3 V 787 - G.H5 A 342 G.H5.09
Hydrophobic ICL2 V 700 - G.H5 I 348 G.H5.15
Van-der-waals ICL2 V 700 - G.H5 I 348 G.H5.15
Hydrophobic ICL3 L 790 - G.H5 Q 350 G.H5.17
Van-der-waals ICL3 L 790 - G.H5 Q 350 G.H5.17
Hydrophobic ICL2 L 697 - G.H5 L 353 G.H5.20
Hydrophobic TM6 L 796 6x38 G.H5 V 359 G.H5.26
Polar H8 N 848 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 N 848 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 N 848 8x47 G.H5 N 357 G.H5.24
Polar TM5 S 782 5x67 G.H5 K 345 G.H5.12
Van-der-waals TM5 S 782 5x67 G.H5 K 345 G.H5.12
Hydrophobic ICL3 L 790 - G.H5 L 353 G.H5.20
Van-der-waals ICL2 V 700 - G.hns1 R 37 G.hns1.02
Hydrophobic TM6 K 799 6x41 G.H5 L 358 G.H5.25
Van-der-waals TM6 K 799 6x41 G.H5 L 358 G.H5.25
Hydrophobic C-term T 871 - G.H3 W 263 G.H3.17
Hydrophobic ICL3 V 787 - G.H5 A 343 G.H5.10
Hydrophobic TM5 V 783 5x68 G.H5 L 349 G.H5.16
Van-der-waals TM5 V 783 5x68 G.H5 L 349 G.H5.16
Hydrophobic TM6 L 796 6x38 G.H5 L 353 G.H5.20
Polar TM6 K 799 6x41 G.H5 N 357 G.H5.24
Hydrophobic TM6 K 799 6x41 G.H5 N 357 G.H5.24
Van-der-waals TM6 K 799 6x41 G.H5 N 357 G.H5.24
Polar C-term I 874 - G.H3 Y 261 G.H3.15
Hydrophobic C-term I 874 - G.H3 Y 261 G.H3.15
Van-der-waals C-term I 874 - G.H3 Y 261 G.H3.15
Hydrophobic ICL2 K 698 - G.H5 K 345 G.H5.12
Hydrophobic ICL3 T 789 - G.h4s6 I 323 G.h4s6.20
Van-der-waals ICL3 T 789 - G.h4s6 I 323 G.h4s6.20
Hydrophobic ICL3 N 784 - G.H5 A 342 G.H5.09
Hydrophobic TM5 L 776 5x61 G.H5 L 353 G.H5.20
Polar ICL3 T 789 - G.H5 D 346 G.H5.13
Van-der-waals ICL3 T 789 - G.H5 D 346 G.H5.13
Polar TM2 N 632 2x44 G.H5 E 355 G.H5.22
Hydrophobic TM5 V 783 5x68 G.H5 D 346 G.H5.13
Van-der-waals TM5 V 783 5x68 G.H5 D 346 G.H5.13
Hydrophobic C-term S 878 - G.H2 R 210 G.H2.01
Hydrophobic C-term L 876 - G.H3 Y 261 G.H3.15
Van-der-waals C-term L 876 - G.H3 Y 261 G.H3.15
Hydrophobic TM3 V 694 3x58 G.H5 L 358 G.H5.25
Hydrophobic TM5 L 780 5x65 G.H5 L 353 G.H5.20
Hydrophobic C-term L 876 - G.H3 T 257 G.H3.11
Polar TM2 N 634 2x46 G.H5 E 355 G.H5.22
Hydrophobic ICL3 V 787 - G.S6 Y 325 G.S6.02
Van-der-waals ICL3 V 787 - G.S6 Y 325 G.S6.02
Hydrophobic ICL2 L 697 - G.H5 L 349 G.H5.16
Hydrophobic ICL3 V 787 - G.H5 F 339 G.H5.06
Van-der-waals ICL3 V 787 - G.H5 F 339 G.H5.06
Hydrophobic C-term L 876 - G.H2 R 213 G.H2.04
Van-der-waals C-term L 876 - G.H2 R 213 G.H2.04
Aromatic ICL2 F 703 - G.H5 Y 356 G.H5.23
Hydrophobic ICL2 F 703 - G.H5 Y 356 G.H5.23
Van-der-waals ICL2 F 703 - G.H5 Y 356 G.H5.23
Hydrophobic ICL2 V 699 - G.H5 I 348 G.H5.15
Hydrophobic TM5 R 779 5x64 G.H5 L 349 G.H5.16
Hydrophobic ICL2 V 700 - G.S1 L 40 G.S1.02
Van-der-waals ICL2 V 700 - G.S1 L 40 G.S1.02
Hydrophobic ICL2 F 703 - G.H5 E 355 G.H5.22
Van-der-waals ICL2 F 703 - G.H5 E 355 G.H5.22
Polar ICL2 S 705 - G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 S 705 - G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 S 705 - G.hns1 R 37 G.hns1.02
Polar ICL3 T 789 - G.H5 Q 350 G.H5.17
Van-der-waals ICL3 T 789 - G.H5 Q 350 G.H5.17
Hydrophobic TM6 L 796 6x38 G.H5 L 358 G.H5.25
Van-der-waals TM6 L 796 6x38 G.H5 L 358 G.H5.25
Polar ICL2 N 701 - G.hns1 A 36 G.hns1.01