Gi1 - ADGRE5 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 86.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 12.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic H8 K 792 8x49 G.H5 D 350 G.H5.22
Polar H8 K 792 8x49 G.H5 D 350 G.H5.22
Hydrophobic H8 K 792 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 K 792 8x49 G.H5 D 350 G.H5.22
Hydrophobic ICL2 G 647 - G.hns1 A 30 G.hns1.01
Hydrophobic TM5 I 725 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 I 725 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM3 R 643 3x60 G.hns1 R 32 G.hns1.03
Van-der-waals ICL3 N 726 - G.H5 F 354 G.H5.26
Hydrophobic TM3 L 640 3x57 G.H5 L 353 G.H5.25
Van-der-waals TM3 L 640 3x57 G.H5 L 353 G.H5.25
Hydrophobic ICL2 F 645 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 645 - G.S3 L 194 G.S3.01
Hydrophobic ICL2 F 645 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 F 645 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 F 645 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 F 645 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 Q 646 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 F 645 - G.h2s4 T 219 G.h2s4.05
Van-der-waals ICL2 F 645 - G.h2s4 T 219 G.h2s4.05
Hydrophobic ICL2 F 645 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 F 645 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 V 644 - G.S3 L 194 G.S3.01
Hydrophobic ICL3 M 729 - G.H5 F 354 G.H5.26
Polar TM2 R 579 2x46 G.H5 C 351 G.H5.23
Van-der-waals TM2 R 579 2x46 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 643 3x60 G.hns1 A 31 G.hns1.02
Van-der-waals TM3 R 643 3x60 G.hns1 A 31 G.hns1.02
Hydrophobic TM5 I 725 5x68 G.H5 K 345 G.H5.17
Polar ICL2 G 647 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 G 647 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 G 647 - G.hns1 A 31 G.hns1.02
Hydrophobic TM3 V 641 3x58 G.H5 L 348 G.H5.20
Aromatic TM5 F 722 5x65 G.H5 F 354 G.H5.26
Hydrophobic TM5 F 722 5x65 G.H5 F 354 G.H5.26
Van-der-waals TM5 F 722 5x65 G.H5 F 354 G.H5.26
Polar H8 K 791 8x48 G.h4s6 T 316 G.h4s6.10
Hydrophobic H8 K 791 8x48 G.h4s6 T 316 G.h4s6.10
Van-der-waals H8 K 791 8x48 G.h4s6 T 316 G.h4s6.10
Polar ICL2 F 645 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 F 645 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 F 645 - G.hns1 A 31 G.hns1.02
Hydrophobic TM5 L 718 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM3 L 637 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 L 637 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 641 3x58 G.H5 L 353 G.H5.25
Van-der-waals TM3 V 641 3x58 G.H5 L 353 G.H5.25
Ionic TM3 R 643 3x60 G.HN E 28 G.HN.52
Polar TM3 R 643 3x60 G.HN E 28 G.HN.52
Hydrophobic TM3 R 643 3x60 G.HN E 28 G.HN.52
Van-der-waals TM3 R 643 3x60 G.HN E 28 G.HN.52
Hydrophobic TM5 L 718 5x61 G.H5 L 348 G.H5.20
Polar TM6 T 741 6x41 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 741 6x41 G.H5 L 353 G.H5.25
Polar ICL3 N 726 - G.H5 K 345 G.H5.17
Van-der-waals TM6 Q 745 6x45 G.H5 L 353 G.H5.25
Hydrophobic ICL2 V 644 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 V 644 - G.H5 I 344 G.H5.16
Hydrophobic TM3 L 640 3x57 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 640 3x57 G.H5 C 351 G.H5.23
Ionic H8 K 792 8x49 G.h3s5 D 261 G.h3s5.02
Polar H8 K 792 8x49 G.h3s5 D 261 G.h3s5.02
Hydrophobic H8 K 792 8x49 G.h3s5 D 261 G.h3s5.02
Van-der-waals H8 K 792 8x49 G.h3s5 D 261 G.h3s5.02
Hydrophobic ICL2 F 645 - G.S1 V 34 G.S1.02
Van-der-waals ICL2 F 645 - G.S1 V 34 G.S1.02
Hydrophobic TM5 I 725 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 I 725 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL2 V 644 - G.H5 N 347 G.H5.19