Gi2 - ADGRF2 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 83.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 551 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 F 551 - G.S3 L 195 G.S3.01
Hydrophobic TM5 T 629 5x61 G.H5 L 349 G.H5.20
Van-der-waals TM5 T 629 5x61 G.H5 L 349 G.H5.20
Polar TM3 G 546 3x57 G.H5 N 348 G.H5.19
Hydrophobic TM3 G 546 3x57 G.H5 N 348 G.H5.19
Van-der-waals TM3 G 546 3x57 G.H5 N 348 G.H5.19
Polar ICL1 T 478 - G.H5 D 351 G.H5.22
Hydrophobic ICL1 T 478 - G.H5 D 351 G.H5.22
Van-der-waals ICL1 T 478 - G.H5 D 351 G.H5.22
Ionic C-term H 704 - G.h3s5 D 262 G.h3s5.02
Hydrophobic TM4 P 555 4x38 G.HN E 28 G.HN.52
Hydrophobic TM3 I 547 3x58 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 547 3x58 G.H5 L 349 G.H5.20
Polar ICL3 R 643 - G.h4s6 K 315 G.h4s6.08
Hydrophobic ICL3 R 643 - G.h4s6 K 315 G.h4s6.08
Van-der-waals ICL3 R 643 - G.h4s6 K 315 G.h4s6.08
Hydrophobic TM2 R 484 2x46 G.H5 G 353 G.H5.24
Van-der-waals TM2 R 484 2x46 G.H5 G 353 G.H5.24
Hydrophobic ICL2 F 551 - G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 F 551 - G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL3 A 632 - G.S6 Y 321 G.S6.02
Hydrophobic ICL1 I 480 - G.H5 C 352 G.H5.23
Van-der-waals ICL1 I 480 - G.H5 C 352 G.H5.23
Hydrophobic ICL2 V 550 - G.H5 I 345 G.H5.16
Van-der-waals ICL2 V 550 - G.H5 I 345 G.H5.16
Hydrophobic ICL2 F 551 - G.H5 T 341 G.H5.12
Van-der-waals ICL2 F 551 - G.H5 T 341 G.H5.12
Hydrophobic ICL3 F 639 - G.h4s6 K 315 G.h4s6.08
Hydrophobic TM6 N 651 6x35 G.H5 L 354 G.H5.25
Hydrophobic ICL1 T 481 - G.H5 D 351 G.H5.22
Van-der-waals ICL1 T 481 - G.H5 D 351 G.H5.22
Hydrophobic TM6 L 655 6x39 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 655 6x39 G.H5 L 354 G.H5.25
Ionic ICL2 H 552 - G.s2s3 D 194 G.s2s3.02
Polar ICL2 H 552 - G.s2s3 D 194 G.s2s3.02
Hydrophobic ICL2 H 552 - G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL2 H 552 - G.s2s3 D 194 G.s2s3.02
Hydrophobic TM5 T 629 5x61 G.H5 F 355 G.H5.26
Hydrophobic ICL1 I 480 - G.H5 D 351 G.H5.22
Van-der-waals ICL1 I 480 - G.H5 D 351 G.H5.22
Aromatic ICL3 R 647 - G.H5 F 355 G.H5.26
Hydrophobic ICL3 R 647 - G.H5 F 355 G.H5.26
Van-der-waals ICL3 R 647 - G.H5 F 355 G.H5.26
Hydrophobic ICL2 V 550 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 V 550 - G.H5 I 344 G.H5.15
Hydrophobic ICL2 V 550 - G.H5 T 341 G.H5.12
Polar TM6 N 651 6x35 G.H5 F 355 G.H5.26
Hydrophobic TM6 N 651 6x35 G.H5 F 355 G.H5.26
Van-der-waals TM6 N 651 6x35 G.H5 F 355 G.H5.26
Polar ICL3 Q 640 - G.H4 E 309 G.H4.16
Van-der-waals ICL3 Q 640 - G.H4 E 309 G.H4.16
Hydrophobic ICL1 I 480 - G.H5 N 348 G.H5.19
Van-der-waals ICL1 I 480 - G.H5 N 348 G.H5.19
Hydrophobic TM5 V 625 5x57 G.H5 L 354 G.H5.25
Hydrophobic TM3 I 543 3x54 G.H5 L 349 G.H5.20
Polar TM2 R 484 2x46 G.H5 D 351 G.H5.22
Hydrophobic TM2 R 484 2x46 G.H5 D 351 G.H5.22
Van-der-waals TM2 R 484 2x46 G.H5 D 351 G.H5.22
Polar TM2 R 484 2x46 G.H5 C 352 G.H5.23
Hydrophobic TM2 R 484 2x46 G.H5 C 352 G.H5.23
Van-der-waals TM2 R 484 2x46 G.H5 C 352 G.H5.23
Hydrophobic TM3 I 543 3x54 G.H5 L 354 G.H5.25
Hydrophobic TM5 V 625 5x57 G.H5 L 349 G.H5.20
Ionic ICL3 R 647 - G.h4s6 E 319 G.h4s6.12
Polar ICL3 R 647 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 R 647 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 R 647 - G.h4s6 E 319 G.h4s6.12
Polar TM4 K 556 4x39 G.HN E 28 G.HN.52
Polar TM4 S 557 4x40 G.HN R 24 G.HN.48
Hydrophobic TM4 S 557 4x40 G.HN R 24 G.HN.48
Van-der-waals TM4 S 557 4x40 G.HN R 24 G.HN.48
Hydrophobic ICL3 R 643 - G.h4s6 D 316 G.h4s6.09
Hydrophobic TM4 K 556 4x39 G.HN R 24 G.HN.48
Hydrophobic TM3 I 547 3x58 G.H5 I 345 G.H5.16
Polar ICL2 T 553 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 553 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 T 553 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 I 543 3x54 G.H5 C 352 G.H5.23