GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 86.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | L | 1055 | - | G.H3 | T | 253 | G.H3.11 |
Hydrophobic | ICL3 | P | 960 | - | G.H4 | L | 306 | G.H4.12 |
Hydrophobic | ICL2 | V | 873 | - | G.H5 | K | 341 | G.H5.12 |
Van-der-waals | ICL2 | V | 873 | - | G.H5 | K | 341 | G.H5.12 |
Hydrophobic | C-term | L | 1052 | - | G.H2 | I | 213 | G.H2.08 |
Polar | C-term | S | 1059 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | S | 1059 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | ICL3 | L | 956 | - | G.H5 | A | 338 | G.H5.09 |
Van-der-waals | ICL3 | L | 956 | - | G.H5 | A | 338 | G.H5.09 |
Hydrophobic | ICL2 | V | 873 | - | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | TM3 | L | 866 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | K | 973 | 6x40 | G.H5 | L | 354 | G.H5.25 |
Ionic | H8 | K | 1026 | 8x49 | G.H5 | E | 351 | G.H5.22 |
Polar | H8 | K | 1026 | 8x49 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | H8 | K | 1026 | 8x49 | G.H5 | E | 351 | G.H5.22 |
Van-der-waals | H8 | K | 1026 | 8x49 | G.H5 | E | 351 | G.H5.22 |
Polar | TM2 | R | 808 | 2x46 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | TM2 | R | 808 | 2x46 | G.H5 | E | 351 | G.H5.22 |
Van-der-waals | TM2 | R | 808 | 2x46 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | TM3 | Q | 862 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Polar | C-term | L | 1052 | - | G.H3 | Y | 257 | G.H3.15 |
Polar | TM6 | K | 973 | 6x40 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | TM6 | K | 973 | 6x40 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM6 | K | 973 | 6x40 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | ICL3 | G | 959 | - | G.H4 | L | 306 | G.H4.12 |
Van-der-waals | ICL3 | G | 959 | - | G.H4 | L | 306 | G.H4.12 |
Hydrophobic | TM3 | L | 866 | 3x54 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | L | 866 | 3x54 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM2 | R | 808 | 2x46 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | ICL2 | F | 874 | - | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | F | 874 | - | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL1 | S | 805 | - | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | TM3 | L | 870 | 3x58 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | L | 870 | 3x58 | G.H5 | L | 349 | G.H5.20 |
Polar | ICL3 | E | 958 | - | G.S6 | S | 322 | G.S6.03 |
Hydrophobic | ICL3 | E | 958 | - | G.S6 | S | 322 | G.S6.03 |
Van-der-waals | ICL3 | E | 958 | - | G.S6 | S | 322 | G.S6.03 |
Hydrophobic | ICL3 | L | 956 | - | G.H5 | D | 342 | G.H5.13 |
Polar | ICL3 | S | 957 | - | G.S6 | I | 320 | G.S6.01 |
Hydrophobic | C-term | S | 1056 | - | G.H2 | R | 210 | G.H2.05 |
Hydrophobic | TM6 | L | 978 | 6x45 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | L | 978 | 6x45 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | C-term | L | 1055 | - | G.H3 | I | 254 | G.H3.12 |
Hydrophobic | TM5 | L | 951 | 5x61 | G.H5 | V | 355 | G.H5.26 |
Ionic | ICL1 | K | 803 | - | G.HN | D | 31 | G.HN.53 |
Polar | ICL1 | K | 803 | - | G.HN | D | 31 | G.HN.53 |
Polar | ICL1 | N | 802 | - | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | ICL1 | N | 802 | - | G.H5 | E | 351 | G.H5.22 |
Van-der-waals | ICL1 | N | 802 | - | G.H5 | E | 351 | G.H5.22 |
Ionic | TM4 | R | 881 | 4x41 | G.HN | D | 28 | G.HN.50 |
Aromatic | ICL2 | F | 874 | - | G.H5 | F | 337 | G.H5.08 |
Hydrophobic | ICL2 | F | 874 | - | G.H5 | F | 337 | G.H5.08 |
Van-der-waals | ICL2 | F | 874 | - | G.H5 | F | 337 | G.H5.08 |
Hydrophobic | C-term | L | 1055 | - | G.H2 | W | 212 | G.H2.07 |
Polar | TM7 | M | 1023 | 7x60 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | TM7 | M | 1023 | 7x60 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM7 | M | 1023 | 7x60 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | C-term | L | 1055 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Hydrophobic | TM5 | L | 951 | 5x61 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | C-term | I | 1054 | - | G.H3 | T | 253 | G.H3.11 |
Hydrophobic | ICL1 | I | 804 | - | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | ICL3 | S | 957 | - | G.S6 | Y | 321 | G.S6.02 |
Polar | C-term | S | 1059 | - | G.s4h3 | E | 241 | G.s4h3.14 |
Hydrophobic | C-term | S | 1059 | - | G.s4h3 | E | 241 | G.s4h3.14 |
Van-der-waals | C-term | S | 1059 | - | G.s4h3 | E | 241 | G.s4h3.14 |
Ionic | H8 | R | 1025 | 8x48 | G.h4s6 | E | 317 | G.h4s6.12 |
Polar | H8 | R | 1025 | 8x48 | G.h4s6 | E | 317 | G.h4s6.12 |
Hydrophobic | H8 | R | 1025 | 8x48 | G.h4s6 | E | 317 | G.h4s6.12 |
Van-der-waals | H8 | R | 1025 | 8x48 | G.h4s6 | E | 317 | G.h4s6.12 |
Hydrophobic | ICL3 | L | 956 | - | G.S6 | Y | 321 | G.S6.02 |
Polar | ICL3 | E | 958 | - | G.S6 | F | 324 | G.S6.05 |
Hydrophobic | ICL3 | E | 958 | - | G.S6 | F | 324 | G.S6.05 |
Van-der-waals | ICL3 | E | 958 | - | G.S6 | F | 324 | G.S6.05 |
Hydrophobic | ICL3 | L | 956 | - | G.H5 | A | 339 | G.H5.10 |
Hydrophobic | TM3 | L | 870 | 3x58 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | TM3 | L | 870 | 3x58 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | ICL2 | F | 874 | - | G.S1 | L | 36 | G.S1.02 |
Van-der-waals | ICL2 | F | 874 | - | G.S1 | L | 36 | G.S1.02 |
Polar | ICL3 | S | 957 | - | G.S6 | S | 322 | G.S6.03 |
Van-der-waals | ICL3 | S | 957 | - | G.S6 | S | 322 | G.S6.03 |
Ionic | ICL3 | E | 958 | - | G.S6 | H | 323 | G.S6.04 |
Polar | ICL3 | E | 958 | - | G.S6 | H | 323 | G.S6.04 |
Hydrophobic | ICL3 | E | 958 | - | G.S6 | H | 323 | G.S6.04 |
Van-der-waals | ICL3 | E | 958 | - | G.S6 | H | 323 | G.S6.04 |
Hydrophobic | ICL1 | I | 804 | - | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL1 | I | 804 | - | G.H5 | N | 348 | G.H5.19 |
Polar | C-term | C | 1051 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | C-term | C | 1051 | - | G.H3 | Y | 257 | G.H3.15 |
Van-der-waals | C-term | C | 1051 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | TM5 | K | 950 | 5x60 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | C-term | L | 1055 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | TM6 | I | 977 | 6x44 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM6 | I | 977 | 6x44 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | C-term | L | 1055 | - | G.H3 | L | 250 | G.H3.08 |
Hydrophobic | H8 | D | 1024 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | H8 | D | 1024 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | ICL2 | V | 873 | - | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | V | 873 | - | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | ICL2 | F | 874 | - | G.H5 | V | 340 | G.H5.11 |
Hydrophobic | ICL1 | I | 804 | - | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | ICL2 | Q | 876 | - | G.hns1 | R | 34 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 876 | - | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | TM3 | V | 865 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | ICL2 | F | 874 | - | G.H5 | K | 341 | G.H5.12 |
Hydrophobic | ICL3 | L | 956 | - | G.H5 | F | 335 | G.H5.06 |
Van-der-waals | ICL3 | L | 956 | - | G.H5 | F | 335 | G.H5.06 |
Hydrophobic | ICL3 | E | 958 | - | G.H4 | L | 306 | G.H4.12 |
Van-der-waals | ICL3 | E | 958 | - | G.H4 | L | 306 | G.H4.12 |
Hydrophobic | TM6 | A | 974 | 6x41 | G.H5 | L | 354 | G.H5.25 |
Polar | TM3 | Q | 869 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | Q | 869 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | Q | 869 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Polar | ICL2 | V | 873 | - | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | ICL2 | F | 874 | - | G.S3 | I | 195 | G.S3.01 |
Van-der-waals | ICL2 | F | 874 | - | G.S3 | I | 195 | G.S3.01 |
Polar | TM6 | K | 973 | 6x40 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | TM6 | K | 973 | 6x40 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM6 | K | 973 | 6x40 | G.H5 | V | 355 | G.H5.26 |
Polar | TM2 | R | 808 | 2x46 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM2 | R | 808 | 2x46 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM2 | R | 808 | 2x46 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM3 | Q | 869 | 3x57 | G.H5 | F | 352 | G.H5.23 |