GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 82.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | L | 1115 | 3x58 | G.H5 | N | 348 | G.H5.19 |
Aromatic | C-term | F | 1313 | - | G.H3 | W | 259 | G.H3.17 |
Hydrophobic | C-term | F | 1313 | - | G.H3 | W | 259 | G.H3.17 |
Van-der-waals | C-term | F | 1313 | - | G.H3 | W | 259 | G.H3.17 |
Ionic | ICL3 | K | 1205 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | ICL3 | K | 1205 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | ICL3 | K | 1205 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | ICL3 | K | 1205 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | ICL2 | E | 1121 | - | G.HN | Q | 28 | G.HN.52 |
Hydrophobic | C-term | F | 1317 | - | G.H3 | L | 250 | G.H3.08 |
Van-der-waals | C-term | F | 1317 | - | G.H3 | L | 250 | G.H3.08 |
Polar | TM5 | D | 1204 | 5x68 | G.S6 | S | 322 | G.S6.03 |
Van-der-waals | TM5 | D | 1204 | 5x68 | G.S6 | S | 322 | G.S6.03 |
Polar | C-term | Y | 1323 | - | G.H3 | L | 248 | G.H3.06 |
Hydrophobic | C-term | Y | 1323 | - | G.H3 | L | 248 | G.H3.06 |
Hydrophobic | TM5 | I | 1202 | 5x66 | G.H5 | A | 339 | G.H5.10 |
Hydrophobic | ICL2 | I | 1118 | - | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | TM5 | V | 1193 | 5x57 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM5 | V | 1193 | 5x57 | G.H5 | L | 354 | G.H5.25 |
Polar | C-term | S | 1326 | - | G.hgh4 | C | 287 | G.hgh4.01 |
Van-der-waals | C-term | S | 1326 | - | G.hgh4 | C | 287 | G.hgh4.01 |
Hydrophobic | C-term | V | 1325 | - | G.hgh4 | C | 287 | G.hgh4.01 |
Van-der-waals | C-term | V | 1325 | - | G.hgh4 | C | 287 | G.hgh4.01 |
Polar | ICL2 | H | 1120 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | H | 1120 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | I | 1118 | - | G.H5 | I | 345 | G.H5.16 |
Ionic | ICL2 | E | 1121 | - | G.hns1 | R | 31 | G.hns1.02 |
Polar | ICL2 | E | 1121 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | ICL2 | E | 1121 | - | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | ICL2 | E | 1121 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | TM5 | G | 1203 | 5x67 | G.S6 | S | 322 | G.S6.03 |
Van-der-waals | TM5 | G | 1203 | 5x67 | G.S6 | S | 322 | G.S6.03 |
Hydrophobic | C-term | T | 1327 | - | G.s4h3 | Q | 240 | G.s4h3.13 |
Van-der-waals | C-term | T | 1327 | - | G.s4h3 | Q | 240 | G.s4h3.13 |
Hydrophobic | TM5 | G | 1203 | 5x67 | G.H5 | F | 335 | G.H5.06 |
Van-der-waals | TM5 | G | 1203 | 5x67 | G.H5 | F | 335 | G.H5.06 |
Polar | TM6 | K | 1219 | 6x40 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | TM6 | K | 1219 | 6x40 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | TM6 | K | 1219 | 6x40 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | C-term | L | 1316 | - | G.H3 | N | 257 | G.H3.15 |
Van-der-waals | C-term | L | 1316 | - | G.H3 | N | 257 | G.H3.15 |
Hydrophobic | TM3 | L | 1115 | 3x58 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | L | 1115 | 3x58 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM5 | K | 1196 | 5x60 | G.H5 | I | 345 | G.H5.16 |
Polar | C-term | Y | 1323 | - | G.H3 | D | 252 | G.H3.10 |
Hydrophobic | C-term | Y | 1323 | - | G.H3 | D | 252 | G.H3.10 |
Van-der-waals | C-term | Y | 1323 | - | G.H3 | D | 252 | G.H3.10 |
Hydrophobic | C-term | T | 1327 | - | G.s4h3 | T | 241 | G.s4h3.14 |
Hydrophobic | C-term | Y | 1323 | - | G.h4s6 | L | 311 | G.h4s6.01 |
Van-der-waals | C-term | Y | 1323 | - | G.h4s6 | L | 311 | G.h4s6.01 |
Hydrophobic | C-term | F | 1317 | - | G.H2 | W | 212 | G.H2.07 |
Hydrophobic | C-term | V | 1325 | - | G.s4h3 | S | 242 | G.s4h3.15 |
Hydrophobic | TM5 | I | 1202 | 5x66 | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | TM5 | I | 1202 | 5x66 | G.S6 | Y | 321 | G.S6.02 |
Polar | ICL1 | S | 1047 | - | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM2 | R | 1050 | 2x46 | G.H5 | G | 353 | G.H5.24 |
Polar | C-term | S | 1326 | - | G.HG | T | 285 | G.HG.16 |
Hydrophobic | C-term | P | 1328 | - | G.HG | I | 286 | G.HG.17 |
Van-der-waals | C-term | P | 1328 | - | G.HG | I | 286 | G.HG.17 |
Hydrophobic | TM6 | V | 1223 | 6x44 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | C-term | Y | 1323 | - | G.H3 | R | 249 | G.H3.07 |
Van-der-waals | C-term | Y | 1323 | - | G.H3 | R | 249 | G.H3.07 |
Ionic | TM5 | D | 1204 | 5x68 | G.S6 | H | 323 | G.S6.04 |
Polar | TM5 | D | 1204 | 5x68 | G.S6 | H | 323 | G.S6.04 |
Van-der-waals | TM5 | D | 1204 | 5x68 | G.S6 | H | 323 | G.S6.04 |
Hydrophobic | TM6 | L | 1224 | 6x45 | G.H5 | L | 354 | G.H5.25 |
Polar | TM6 | Q | 1216 | 6x37 | G.H5 | Q | 346 | G.H5.17 |
Polar | ICL3 | Q | 1209 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | C-term | V | 1325 | - | G.hgh4 | F | 288 | G.hgh4.02 |
Polar | ICL2 | T | 1122 | - | G.HN | Q | 28 | G.HN.52 |
Hydrophobic | TM5 | I | 1202 | 5x66 | G.H5 | F | 335 | G.H5.06 |
Van-der-waals | TM5 | I | 1202 | 5x66 | G.H5 | F | 335 | G.H5.06 |
Hydrophobic | C-term | F | 1313 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Polar | H8 | K | 1272 | 8x49 | G.H5 | K | 350 | G.H5.21 |
Hydrophobic | H8 | K | 1272 | 8x49 | G.H5 | K | 350 | G.H5.21 |
Van-der-waals | H8 | K | 1272 | 8x49 | G.H5 | K | 350 | G.H5.21 |
Van-der-waals | H8 | K | 1272 | 8x49 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | C-term | S | 1326 | - | G.hgh4 | P | 289 | G.hgh4.03 |
Van-der-waals | C-term | S | 1326 | - | G.hgh4 | P | 289 | G.hgh4.03 |
Hydrophobic | TM3 | L | 1115 | 3x58 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM3 | L | 1115 | 3x58 | G.H5 | I | 345 | G.H5.16 |
Polar | TM3 | R | 1114 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | R | 1114 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | R | 1114 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Polar | TM5 | D | 1204 | 5x68 | G.H4 | Q | 305 | G.H4.12 |
Van-der-waals | TM5 | D | 1204 | 5x68 | G.H4 | Q | 305 | G.H4.12 |
Hydrophobic | TM5 | I | 1202 | 5x66 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | I | 1202 | 5x66 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | C-term | P | 1328 | - | G.s4h3 | D | 232 | G.s4h3.05 |
Van-der-waals | C-term | P | 1328 | - | G.s4h3 | D | 232 | G.s4h3.05 |
Hydrophobic | ICL1 | T | 1046 | - | G.H5 | I | 352 | G.H5.23 |
Polar | TM5 | S | 1201 | 5x65 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM5 | S | 1201 | 5x65 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM5 | S | 1201 | 5x65 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | ICL3 | K | 1205 | - | G.S6 | I | 320 | G.S6.01 |
Hydrophobic | ICL3 | K | 1205 | - | G.S6 | I | 320 | G.S6.01 |
Van-der-waals | ICL3 | K | 1205 | - | G.S6 | I | 320 | G.S6.01 |
Polar | C-term | F | 1317 | - | G.H3 | R | 249 | G.H3.07 |
Van-der-waals | C-term | F | 1317 | - | G.H3 | R | 249 | G.H3.07 |
Polar | C-term | N | 1324 | - | G.hgh4 | E | 290 | G.hgh4.04 |
Van-der-waals | C-term | N | 1324 | - | G.hgh4 | E | 290 | G.hgh4.04 |
Hydrophobic | ICL1 | T | 1046 | - | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM5 | I | 1197 | 5x61 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL2 | I | 1118 | - | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | ICL2 | I | 1118 | - | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | TM3 | R | 1114 | 3x57 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | C-term | V | 1325 | - | G.H3 | A | 245 | G.H3.03 |
Hydrophobic | TM5 | V | 1193 | 5x57 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM3 | L | 1111 | 3x54 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | L | 1111 | 3x54 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM5 | I | 1202 | 5x66 | G.H5 | D | 338 | G.H5.09 |
Van-der-waals | TM5 | I | 1202 | 5x66 | G.H5 | D | 338 | G.H5.09 |
Polar | C-term | P | 1328 | - | G.s4h3 | K | 234 | G.s4h3.07 |
Hydrophobic | C-term | P | 1328 | - | G.s4h3 | K | 234 | G.s4h3.07 |
Van-der-waals | C-term | P | 1328 | - | G.s4h3 | K | 234 | G.s4h3.07 |
Polar | C-term | L | 1316 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | C-term | L | 1316 | - | G.H3 | S | 253 | G.H3.11 |
Van-der-waals | C-term | L | 1316 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | ICL2 | L | 1119 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | L | 1119 | - | G.S3 | L | 195 | G.S3.01 |
Polar | TM6 | S | 1220 | 6x41 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | S | 1220 | 6x41 | G.H5 | L | 354 | G.H5.25 |
Polar | TM5 | D | 1204 | 5x68 | G.S6 | F | 324 | G.S6.05 |
Hydrophobic | TM5 | D | 1204 | 5x68 | G.S6 | F | 324 | G.S6.05 |
Van-der-waals | TM5 | D | 1204 | 5x68 | G.S6 | F | 324 | G.S6.05 |
Hydrophobic | C-term | V | 1325 | - | G.H3 | L | 248 | G.H3.06 |
Van-der-waals | C-term | V | 1325 | - | G.H3 | L | 248 | G.H3.06 |
Polar | TM2 | R | 1050 | 2x46 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM2 | R | 1050 | 2x46 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM2 | R | 1050 | 2x46 | G.H5 | I | 352 | G.H5.23 |
Polar | ICL1 | N | 1044 | - | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | ICL1 | N | 1044 | - | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | ICL1 | N | 1044 | - | G.H5 | Y | 351 | G.H5.22 |
Polar | TM6 | Q | 1216 | 6x37 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | TM6 | Q | 1216 | 6x37 | G.H5 | C | 355 | G.H5.26 |
Polar | C-term | S | 1326 | - | G.HG | I | 286 | G.HG.17 |
Van-der-waals | C-term | S | 1326 | - | G.HG | I | 286 | G.HG.17 |
Hydrophobic | C-term | F | 1313 | - | G.H2 | I | 213 | G.H2.08 |
Van-der-waals | C-term | F | 1313 | - | G.H2 | I | 213 | G.H2.08 |
Hydrophobic | C-term | F | 1317 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | F | 1317 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | N | 1324 | - | G.hgh4 | P | 289 | G.hgh4.03 |
Hydrophobic | C-term | P | 1328 | - | G.s4h3 | S | 242 | G.s4h3.15 |
Hydrophobic | C-term | L | 1316 | - | G.h2s4 | F | 216 | G.h2s4.01 |