Gi3 - ADGRG2 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic C-term D 974 - G.H2 K 209 G.H2.05
Polar TM7 K 883 7x61 G.H5 E 350 G.H5.22
Hydrophobic C-term L 1011 - G.H4 E 297 G.H4.04
Hydrophobic TM3 L 723 3x58 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 723 3x58 G.H5 L 348 G.H5.20
Hydrophobic TM5 I 815 5x64 G.H5 I 344 G.H5.16
Polar C-term N 972 - G.H2 H 213 G.H2.09
Hydrophobic C-term N 972 - G.H2 H 213 G.H2.09
Van-der-waals C-term N 972 - G.H2 H 213 G.H2.09
Hydrophobic TM6 L 838 6x45 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 808 5x57 G.H5 L 348 G.H5.20
Hydrophobic ICL2 V 726 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 V 726 - G.H5 I 344 G.H5.16
Hydrophobic TM3 L 723 3x58 G.H5 I 344 G.H5.16
Hydrophobic TM5 I 815 5x64 G.H5 L 348 G.H5.20
Van-der-waals TM5 I 815 5x64 G.H5 L 348 G.H5.20
Polar ICL2 N 728 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 N 728 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 728 - G.s2s3 D 193 G.s2s3.02
Polar ICL2 N 728 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 N 728 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 N 728 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 F 727 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 727 - G.S3 L 194 G.S3.01
Hydrophobic TM5 L 812 5x61 G.H5 L 348 G.H5.20
Ionic ICL3 R 825 - G.h4s6 D 315 G.h4s6.09
Polar ICL3 R 825 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL3 R 825 - G.h4s6 D 315 G.h4s6.09
Van-der-waals ICL3 R 825 - G.h4s6 D 315 G.h4s6.09
Polar TM6 Q 830 6x37 G.H5 Y 354 G.H5.26
Hydrophobic TM6 Q 830 6x37 G.H5 Y 354 G.H5.26
Van-der-waals TM6 Q 830 6x37 G.H5 Y 354 G.H5.26
Polar TM5 K 819 5x68 G.H5 Y 354 G.H5.26
Van-der-waals TM5 K 819 5x68 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 V 726 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 V 726 - G.H5 I 343 G.H5.15
Hydrophobic TM2 P 661 2x46 G.H5 C 351 G.H5.23
Hydrophobic ICL2 F 727 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 F 727 - G.H5 T 340 G.H5.12
Hydrophobic ICL2 F 727 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 F 727 - G.H5 I 343 G.H5.15
Hydrophobic C-term F 1013 - G.H4 E 297 G.H4.04
Van-der-waals C-term F 1013 - G.H4 E 297 G.H4.04
Hydrophobic TM5 I 815 5x64 G.H5 Y 354 G.H5.26
Hydrophobic TM5 Q 811 5x60 G.H5 I 344 G.H5.16
Van-der-waals TM5 Q 811 5x60 G.H5 I 344 G.H5.16
Polar C-term T 910 - G.H3 K 257 G.H3.16
Hydrophobic C-term T 910 - G.H3 K 257 G.H3.16
Hydrophobic TM3 L 723 3x58 G.H5 N 347 G.H5.19
Polar TM3 A 722 3x57 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 722 3x57 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 722 3x57 G.H5 N 347 G.H5.19
Polar TM5 K 819 5x68 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM5 K 819 5x68 G.h4s6 D 315 G.h4s6.09
Polar TM6 S 834 6x41 G.H5 L 353 G.H5.25
Hydrophobic TM6 S 834 6x41 G.H5 L 353 G.H5.25
Van-der-waals TM6 S 834 6x41 G.H5 L 353 G.H5.25
Ionic TM5 K 818 5x67 G.H5 D 341 G.H5.13
Polar TM5 K 818 5x67 G.H5 D 341 G.H5.13
Van-der-waals TM5 K 818 5x67 G.H5 D 341 G.H5.13
Hydrophobic TM5 L 812 5x61 G.H5 Y 354 G.H5.26
Aromatic ICL2 F 727 - G.H5 F 336 G.H5.08
Hydrophobic ICL2 F 727 - G.H5 F 336 G.H5.08
Van-der-waals ICL2 F 727 - G.H5 F 336 G.H5.08
Hydrophobic C-term L 977 - G.H2 K 209 G.H2.05
Polar ICL2 Y 730 - G.HN E 28 G.HN.52
Hydrophobic ICL2 Y 730 - G.HN E 28 G.HN.52
Van-der-waals ICL2 Y 730 - G.HN E 28 G.HN.52
Hydrophobic ICL2 V 726 - G.H5 T 340 G.H5.12
Ionic TM5 K 819 5x68 G.h4s6 E 318 G.h4s6.12
Polar TM5 K 819 5x68 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 K 819 5x68 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 K 819 5x68 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 R 732 - G.HN R 24 G.HN.48
Van-der-waals ICL2 R 732 - G.HN R 24 G.HN.48
Hydrophobic TM5 V 808 5x57 G.H5 L 353 G.H5.25
Hydrophobic TM7 K 883 7x61 G.H5 G 352 G.H5.24
Hydrophobic TM2 P 661 2x46 G.H5 E 350 G.H5.22
Hydrophobic ICL2 Y 730 - G.HN G 27 G.HN.51
Polar ICL2 Y 730 - G.HN R 24 G.HN.48
Hydrophobic ICL2 Y 730 - G.HN R 24 G.HN.48
Van-der-waals ICL2 Y 730 - G.HN R 24 G.HN.48