GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | Y | 730 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | C-term | L | 977 | - | H.HA | V | 72 | H.HA.10 |
Van-der-waals | C-term | L | 977 | - | H.HA | V | 72 | H.HA.10 |
Hydrophobic | ICL2 | V | 726 | - | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | V | 726 | - | G.H5 | I | 344 | G.H5.16 |
Polar | ICL2 | N | 728 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | N | 728 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | N | 728 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | V | 726 | - | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | C-term | V | 975 | - | H.HA | F | 69 | H.HA.07 |
Polar | TM5 | K | 819 | 5x68 | G.h4s6 | E | 315 | G.h4s6.09 |
Hydrophobic | TM5 | K | 819 | 5x68 | G.h4s6 | E | 315 | G.h4s6.09 |
Van-der-waals | TM5 | K | 819 | 5x68 | G.h4s6 | E | 315 | G.h4s6.09 |
Polar | C-term | H | 985 | - | H.HB | A | 111 | H.HB.13 |
Hydrophobic | C-term | H | 985 | - | H.HB | A | 111 | H.HB.13 |
Van-der-waals | C-term | H | 985 | - | H.HB | A | 111 | H.HB.13 |
Hydrophobic | TM5 | L | 812 | 5x61 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | F | 980 | - | H.HA | A | 71 | H.HA.09 |
Van-der-waals | C-term | F | 980 | - | H.HA | A | 71 | H.HA.09 |
Hydrophobic | TM3 | H | 718 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | F | 987 | - | H.HB | Y | 108 | H.HB.10 |
Polar | C-term | G | 982 | - | H.hbhc | D | 116 | H.hbhc.04 |
Hydrophobic | C-term | G | 982 | - | H.hbhc | D | 116 | H.hbhc.04 |
Van-der-waals | C-term | G | 982 | - | H.hbhc | D | 116 | H.hbhc.04 |
Hydrophobic | C-term | L | 977 | - | H.HA | E | 68 | H.HA.06 |
Van-der-waals | C-term | L | 977 | - | H.HA | E | 68 | H.HA.06 |
Polar | TM6 | Q | 830 | 6x37 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | Q | 830 | 6x37 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | Q | 830 | 6x37 | G.H5 | F | 354 | G.H5.26 |
Polar | C-term | S | 969 | - | G.S2 | I | 184 | G.S2.01 |
Hydrophobic | TM6 | L | 838 | 6x45 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | F | 980 | - | H.hbhc | G | 117 | H.hbhc.12 |
Hydrophobic | C-term | F | 980 | - | H.HA | S | 75 | H.HA.13 |
Van-der-waals | C-term | F | 980 | - | H.HA | S | 75 | H.HA.13 |
Hydrophobic | ICL2 | Y | 730 | - | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | Y | 730 | - | G.HN | E | 28 | G.HN.52 |
Polar | ICL2 | N | 728 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL2 | N | 728 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | N | 728 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | TM5 | V | 808 | 5x57 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | V | 975 | - | H.HA | E | 68 | H.HA.06 |
Van-der-waals | C-term | V | 975 | - | H.HA | E | 68 | H.HA.06 |
Polar | C-term | N | 972 | - | G.h1ha | K | 58 | G.h1ha.01 |
Van-der-waals | C-term | N | 972 | - | G.h1ha | K | 58 | G.h1ha.01 |
Hydrophobic | ICL2 | F | 727 | - | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | F | 727 | - | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | C-term | L | 977 | - | G.hfs2 | V | 179 | G.hfs2.03 |
Van-der-waals | C-term | L | 977 | - | G.hfs2 | V | 179 | G.hfs2.03 |
Polar | C-term | H | 985 | - | H.HB | N | 112 | H.HB.14 |
Hydrophobic | C-term | H | 985 | - | H.HB | N | 112 | H.HB.14 |
Van-der-waals | C-term | H | 985 | - | H.HB | N | 112 | H.HB.14 |
Polar | TM6 | S | 834 | 6x41 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | S | 834 | 6x41 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | S | 834 | 6x41 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | L | 977 | - | H.HA | F | 69 | H.HA.07 |
Van-der-waals | C-term | L | 977 | - | H.HA | F | 69 | H.HA.07 |
Aromatic | ICL2 | F | 727 | - | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | ICL2 | F | 727 | - | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | F | 727 | - | G.H5 | F | 336 | G.H5.08 |
Ionic | ICL3 | R | 825 | - | G.h4s6 | E | 315 | G.h4s6.09 |
Polar | ICL3 | R | 825 | - | G.h4s6 | E | 315 | G.h4s6.09 |
Hydrophobic | ICL3 | R | 825 | - | G.h4s6 | E | 315 | G.h4s6.09 |
Van-der-waals | ICL3 | R | 825 | - | G.h4s6 | E | 315 | G.h4s6.09 |
Hydrophobic | TM7 | K | 883 | 7x61 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | C-term | K | 983 | - | H.HA | Q | 79 | H.HA.17 |
Van-der-waals | C-term | K | 983 | - | H.HA | Q | 79 | H.HA.17 |
Polar | ICL2 | R | 732 | - | G.HN | Q | 24 | G.HN.48 |
Hydrophobic | ICL2 | R | 732 | - | G.HN | Q | 24 | G.HN.48 |
Van-der-waals | ICL2 | R | 732 | - | G.HN | Q | 24 | G.HN.48 |
Hydrophobic | TM2 | P | 661 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | P | 661 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | C-term | G | 973 | - | H.HA | E | 65 | H.HA.03 |
Hydrophobic | TM2 | P | 661 | 2x46 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM5 | V | 808 | 5x57 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | F | 727 | - | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | F | 727 | - | G.H5 | I | 343 | G.H5.15 |
Ionic | TM5 | K | 819 | 5x68 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM5 | K | 819 | 5x68 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM5 | K | 819 | 5x68 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM5 | K | 819 | 5x68 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | C-term | H | 985 | - | H.HB | Y | 108 | H.HB.10 |
Hydrophobic | C-term | H | 985 | - | H.HB | Y | 108 | H.HB.10 |
Hydrophobic | TM3 | L | 723 | 3x58 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | Q | 971 | - | G.S2 | I | 185 | G.S2.02 |
Van-der-waals | C-term | Q | 971 | - | G.S2 | I | 185 | G.S2.02 |
Polar | TM7 | K | 883 | 7x61 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM5 | Q | 811 | 5x60 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | Q | 811 | 5x60 | G.H5 | I | 344 | G.H5.16 |
Polar | C-term | Q | 971 | - | G.S2 | E | 186 | G.S2.03 |
Hydrophobic | TM5 | I | 815 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Polar | ICL2 | Y | 730 | - | G.HN | Q | 24 | G.HN.48 |
Hydrophobic | ICL2 | Y | 730 | - | G.HN | Q | 24 | G.HN.48 |
Van-der-waals | ICL2 | Y | 730 | - | G.HN | Q | 24 | G.HN.48 |
Hydrophobic | ICL2 | F | 727 | - | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | F | 727 | - | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | C-term | F | 968 | - | G.S2 | I | 184 | G.S2.01 |
Polar | TM3 | A | 722 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 722 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 722 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | V | 726 | - | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | V | 726 | - | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | C-term | F | 980 | - | H.HA | V | 72 | H.HA.10 |
Van-der-waals | C-term | F | 980 | - | H.HA | V | 72 | H.HA.10 |
Hydrophobic | TM5 | L | 812 | 5x61 | G.H5 | F | 354 | G.H5.26 |
Polar | C-term | S | 969 | - | G.S2 | E | 186 | G.S2.03 |
Hydrophobic | C-term | F | 980 | - | H.hbhc | D | 116 | H.hbhc.04 |
Van-der-waals | C-term | F | 980 | - | H.hbhc | D | 116 | H.hbhc.04 |
Hydrophobic | TM5 | I | 815 | 5x64 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM5 | I | 815 | 5x64 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | V | 975 | - | H.HA | E | 65 | H.HA.03 |
Van-der-waals | C-term | V | 975 | - | H.HA | E | 65 | H.HA.03 |
Polar | C-term | K | 983 | - | H.HA | L | 82 | H.HA.20 |
Hydrophobic | C-term | K | 983 | - | H.HA | L | 82 | H.HA.20 |
Van-der-waals | C-term | K | 983 | - | H.HA | L | 82 | H.HA.20 |
Hydrophobic | TM5 | I | 815 | 5x64 | G.H5 | F | 354 | G.H5.26 |
Ionic | TM5 | K | 818 | 5x67 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | K | 818 | 5x67 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | K | 818 | 5x67 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | K | 818 | 5x67 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL2 | Y | 730 | - | G.HN | A | 27 | G.HN.51 |
Hydrophobic | TM3 | L | 723 | 3x58 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | L | 723 | 3x58 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM3 | L | 723 | 3x58 | G.H5 | N | 347 | G.H5.19 |
Polar | C-term | G | 973 | - | G.H1 | K | 54 | G.H1.09 |
Van-der-waals | C-term | G | 973 | - | G.H1 | K | 54 | G.H1.09 |