Gz - ADGRG2 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 Y 730 - G.HN Q 28 G.HN.52
Hydrophobic ICL2 Y 730 - G.HN Q 28 G.HN.52
Van-der-waals ICL2 Y 730 - G.HN Q 28 G.HN.52
Polar C-term G 973 - G.H3 R 249 G.H3.07
Van-der-waals C-term G 973 - G.H3 R 249 G.H3.07
Hydrophobic C-term F 980 - G.H2 I 213 G.H2.08
Van-der-waals C-term F 980 - G.H2 I 213 G.H2.08
Polar ICL2 N 728 - G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 N 728 - G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 F 727 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 F 727 - G.S3 L 195 G.S3.01
Hydrophobic TM5 Q 811 5x60 G.H5 I 345 G.H5.16
Van-der-waals TM5 Q 811 5x60 G.H5 I 345 G.H5.16
Polar TM6 Q 830 6x37 G.H5 C 355 G.H5.26
Van-der-waals TM6 Q 830 6x37 G.H5 C 355 G.H5.26
Polar TM6 S 834 6x41 G.H5 L 354 G.H5.25
Hydrophobic TM6 S 834 6x41 G.H5 L 354 G.H5.25
Van-der-waals TM6 S 834 6x41 G.H5 L 354 G.H5.25
Hydrophobic TM3 L 723 3x58 G.H5 I 352 G.H5.23
Hydrophobic TM2 P 661 2x46 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 V 726 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 V 726 - G.H5 I 344 G.H5.15
Hydrophobic ICL2 F 727 - G.S1 I 34 G.S1.02
Van-der-waals ICL2 F 727 - G.S1 I 34 G.S1.02
Hydrophobic TM5 L 812 5x61 G.H5 C 355 G.H5.26
Van-der-waals TM5 L 812 5x61 G.H5 C 355 G.H5.26
Polar TM2 Y 660 2x45 G.HN Q 28 G.HN.52
Van-der-waals TM2 Y 660 2x45 G.HN Q 28 G.HN.52
Polar TM5 K 819 5x68 G.h4s6 E 316 G.h4s6.09
Van-der-waals TM5 K 819 5x68 G.h4s6 E 316 G.h4s6.09
Hydrophobic ICL2 V 726 - G.H5 T 341 G.H5.12
Van-der-waals C-term L 977 - G.H3 S 253 G.H3.11
Hydrophobic TM3 L 723 3x58 G.H5 L 349 G.H5.20
Van-der-waals TM3 L 723 3x58 G.H5 L 349 G.H5.20
Hydrophobic TM2 P 661 2x46 G.H5 I 352 G.H5.23
Hydrophobic TM5 L 812 5x61 G.H5 L 354 G.H5.25
Ionic ICL1 R 658 - G.HN D 20 G.HN.44
Polar ICL1 R 658 - G.HN D 20 G.HN.44
Hydrophobic ICL1 R 658 - G.HN D 20 G.HN.44
Van-der-waals ICL1 R 658 - G.HN D 20 G.HN.44
Hydrophobic C-term V 975 - G.H3 R 249 G.H3.07
Van-der-waals C-term V 975 - G.H3 R 249 G.H3.07
Hydrophobic C-term F 968 - G.hgh4 P 289 G.hgh4.03
Polar TM3 A 722 3x57 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 722 3x57 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 722 3x57 G.H5 N 348 G.H5.19
Polar ICL2 T 729 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 T 729 - G.hns1 R 31 G.hns1.02
Polar ICL1 R 658 - G.HN R 24 G.HN.48
Hydrophobic ICL1 R 658 - G.HN R 24 G.HN.48
Van-der-waals ICL1 R 658 - G.HN R 24 G.HN.48
Hydrophobic ICL2 F 727 - G.H5 V 340 G.H5.11
Hydrophobic ICL2 F 727 - G.H5 T 341 G.H5.12
Van-der-waals ICL2 F 727 - G.H5 T 341 G.H5.12
Aromatic ICL2 F 727 - G.H5 F 337 G.H5.08
Hydrophobic ICL2 F 727 - G.H5 F 337 G.H5.08
Van-der-waals ICL2 F 727 - G.H5 F 337 G.H5.08
Polar ICL2 N 728 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 N 728 - G.hns1 R 31 G.hns1.02
Hydrophobic TM2 K 663 2x48 G.HN R 24 G.HN.48
Van-der-waals TM2 K 663 2x48 G.HN R 24 G.HN.48
Hydrophobic ICL2 F 727 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 F 727 - G.H5 I 344 G.H5.15
Van-der-waals TM7 Y 879 7x57 G.H5 I 352 G.H5.23
Hydrophobic TM5 I 815 5x64 G.H5 L 349 G.H5.20
Van-der-waals TM5 I 815 5x64 G.H5 L 349 G.H5.20
Ionic TM5 K 818 5x67 G.H5 D 342 G.H5.13
Polar TM5 K 818 5x67 G.H5 D 342 G.H5.13
Hydrophobic TM5 K 818 5x67 G.H5 D 342 G.H5.13
Van-der-waals TM5 K 818 5x67 G.H5 D 342 G.H5.13
Ionic TM5 K 819 5x68 G.h4s6 E 319 G.h4s6.12
Polar TM5 K 819 5x68 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM5 K 819 5x68 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM5 K 819 5x68 G.h4s6 E 319 G.h4s6.12
Polar TM5 K 819 5x68 G.H5 Q 346 G.H5.17
Polar ICL1 R 658 - G.HN S 16 G.HN.40
Hydrophobic TM5 L 812 5x61 G.H5 L 349 G.H5.20
Hydrophobic TM6 L 838 6x45 G.H5 L 354 G.H5.25
Hydrophobic ICL2 V 726 - G.H5 I 345 G.H5.16
Hydrophobic TM5 V 808 5x57 G.H5 L 354 G.H5.25
Van-der-waals TM5 V 808 5x57 G.H5 L 354 G.H5.25
Ionic ICL3 R 825 - G.h4s6 E 316 G.h4s6.09
Polar ICL3 R 825 - G.h4s6 E 316 G.h4s6.09
Hydrophobic ICL3 R 825 - G.h4s6 E 316 G.h4s6.09
Van-der-waals ICL3 R 825 - G.h4s6 E 316 G.h4s6.09
Van-der-waals TM5 K 818 5x67 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL2 N 728 - G.S3 L 195 G.S3.01
Hydrophobic TM3 L 723 3x58 G.H5 N 348 G.H5.19
Hydrophobic TM3 L 723 3x58 G.H5 I 345 G.H5.16
Polar ICL1 R 657 12x51 G.HN R 24 G.HN.48
Van-der-waals ICL1 R 657 12x51 G.HN R 24 G.HN.48
Hydrophobic TM3 M 719 3x54 G.H5 I 352 G.H5.23
Hydrophobic TM5 V 808 5x57 G.H5 L 349 G.H5.20
Hydrophobic TM5 I 815 5x64 G.H5 I 345 G.H5.16
Ionic ICL1 E 654 12x48 G.HN R 17 G.HN.41
Polar ICL1 E 654 12x48 G.HN R 17 G.HN.41
Hydrophobic ICL1 E 654 12x48 G.HN R 17 G.HN.41
Van-der-waals ICL1 E 654 12x48 G.HN R 17 G.HN.41
Hydrophobic TM5 I 815 5x64 G.H5 Q 346 G.H5.17