G12 - ADGRG3 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.8
PAE mean: 14.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 N 372 - G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 N 372 - G.s2s3 K 220 G.s2s3.02
Hydrophobic TM5 L 460 5x64 G.H5 Q 372 G.H5.17
Van-der-waals TM5 L 460 5x64 G.H5 Q 372 G.H5.17
Polar TM6 T 478 6x41 G.H5 L 380 G.H5.25
Van-der-waals TM6 T 478 6x41 G.H5 L 380 G.H5.25
Hydrophobic TM5 T 464 5x68 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM5 T 464 5x68 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 F 371 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 371 - G.H5 I 370 G.H5.15
Hydrophobic TM5 L 460 5x64 G.H5 L 371 G.H5.16
Van-der-waals TM5 L 460 5x64 G.H5 L 371 G.H5.16
Hydrophobic ICL2 N 372 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 N 372 - G.S3 I 221 G.S3.01
Polar TM3 R 369 3x60 G.H5 K 367 G.H5.12
Hydrophobic TM7 I 523 7x59 G.H5 L 380 G.H5.25
Van-der-waals TM7 I 523 7x59 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 371 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 F 371 - G.H5 K 367 G.H5.12
Hydrophobic TM5 I 457 5x61 G.H5 M 379 G.H5.24
Hydrophobic ICL1 E 298 12x48 G.HN D 44 G.HN.44
Van-der-waals ICL1 E 298 12x48 G.HN D 44 G.HN.44
Hydrophobic TM6 K 474 6x37 G.H5 L 380 G.H5.25
Hydrophobic TM7 W 520 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 W 520 7x56 G.H5 L 380 G.H5.25
Hydrophobic ICL2 V 370 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 V 370 - G.H5 K 367 G.H5.12
Hydrophobic ICL3 V 466 - G.h4s6 R 342 G.h4s6.11
Van-der-waals ICL3 V 466 - G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL2 F 371 - G.S1 V 58 G.S1.02
Hydrophobic TM6 K 475 6x38 G.H5 M 379 G.H5.24
Hydrophobic TM7 L 524 7x60 G.H5 I 378 G.H5.23
Polar TM6 K 474 6x37 G.H5 Q 381 G.H5.26
Hydrophobic TM6 K 474 6x37 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 474 6x37 G.H5 Q 381 G.H5.26
Aromatic ICL2 F 371 - G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 371 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 371 - G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 371 - G.H5 V 366 G.H5.11
Hydrophobic TM3 A 367 3x58 G.H5 L 371 G.H5.16
Van-der-waals TM3 A 367 3x58 G.H5 L 371 G.H5.16
Hydrophobic TM6 T 478 6x41 G.H5 M 379 G.H5.24
Hydrophobic TM6 T 478 6x41 G.H5 I 378 G.H5.23
Hydrophobic ICL2 F 371 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 371 - G.S3 I 221 G.S3.01
Polar TM3 L 366 3x57 G.H5 N 374 G.H5.19
Hydrophobic TM3 L 366 3x57 G.H5 N 374 G.H5.19
Van-der-waals TM3 L 366 3x57 G.H5 N 374 G.H5.19
Hydrophobic ICL2 V 370 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 V 370 - G.H5 I 370 G.H5.15
Hydrophobic TM5 A 463 5x67 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM3 L 366 3x57 G.H5 I 378 G.H5.23
Polar ICL2 Y 374 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 Y 374 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 Y 374 - G.hns1 R 56 G.hns1.03
Hydrophobic TM5 L 460 5x64 G.H5 D 368 G.H5.13
Polar TM3 V 368 3x59 G.H5 K 367 G.H5.12
Van-der-waals TM3 V 368 3x59 G.H5 K 367 G.H5.12
Hydrophobic TM5 K 456 5x60 G.H5 L 371 G.H5.16
Hydrophobic TM6 L 477 6x40 G.H5 L 380 G.H5.25
Van-der-waals TM6 L 477 6x40 G.H5 L 380 G.H5.25
Hydrophobic TM5 I 457 5x61 G.H5 L 375 G.H5.20
Polar ICL2 Y 374 - G.HN R 52 G.HN.52
Hydrophobic ICL2 Y 374 - G.HN R 52 G.HN.52
Van-der-waals ICL2 Y 374 - G.HN R 52 G.HN.52
Hydrophobic ICL2 V 370 - G.H5 L 371 G.H5.16
Hydrophobic TM6 L 482 6x45 G.H5 I 378 G.H5.23
Ionic ICL1 R 299 12x49 G.H5 D 377 G.H5.22
Polar ICL1 R 299 12x49 G.H5 D 377 G.H5.22
Hydrophobic TM7 W 520 7x56 G.H5 I 378 G.H5.23
Van-der-waals TM7 W 520 7x56 G.H5 I 378 G.H5.23
Hydrophobic TM7 L 524 7x60 G.H5 D 377 G.H5.22
Van-der-waals TM7 L 524 7x60 G.H5 D 377 G.H5.22
Hydrophobic ICL3 V 466 - G.h4s6 S 343 G.h4s6.12
Hydrophobic TM7 L 524 7x60 G.H5 L 380 G.H5.25
Hydrophobic TM3 L 363 3x54 G.H5 I 378 G.H5.23