GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 86.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | H8 | S | 510 | 8x50 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | S | 510 | 8x50 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | S | 510 | 8x50 | G.H5 | E | 392 | G.H5.24 |
Polar | TM3 | N | 338 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | N | 338 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Polar | H8 | R | 509 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | R | 509 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | R | 509 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | L | 462 | 6x45 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | L | 462 | 6x45 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | Y | 347 | - | G.S3 | F | 219 | G.S3.03 |
Polar | TM3 | L | 343 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | L | 343 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | L | 343 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
Polar | TM3 | L | 342 | 3x57 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | L | 342 | 3x57 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | L | 342 | 3x57 | G.H5 | H | 387 | G.H5.19 |
Polar | H8 | E | 513 | 8x53 | G.h4s6 | R | 356 | G.h4s6.12 |
Polar | TM5 | R | 440 | 5x63 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | R | 440 | 5x63 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | V | 346 | - | G.H5 | R | 380 | G.H5.12 |
Ionic | ICL3 | R | 444 | - | G.H5 | D | 381 | G.H5.13 |
Polar | ICL3 | R | 444 | - | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | ICL3 | R | 444 | - | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | ICL3 | R | 444 | - | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM7 | W | 502 | 7x56 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM7 | W | 502 | 7x56 | G.H5 | L | 393 | G.H5.25 |
Polar | TM5 | L | 441 | 5x64 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM5 | L | 441 | 5x64 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM5 | L | 441 | 5x64 | G.H5 | R | 385 | G.H5.17 |
Polar | ICL2 | Y | 347 | - | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL2 | Y | 347 | - | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | Y | 347 | - | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | TM7 | W | 502 | 7x56 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | L | 280 | 2x46 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | L | 280 | 2x46 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM5 | T | 437 | 5x60 | G.H5 | Q | 384 | G.H5.16 |
Polar | TM3 | E | 335 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | Y | 347 | - | G.H5 | C | 379 | G.H5.11 |
Van-der-waals | ICL2 | Y | 347 | - | G.H5 | C | 379 | G.H5.11 |
Hydrophobic | ICL2 | I | 349 | - | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | I | 349 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM5 | L | 438 | 5x61 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL2 | V | 346 | - | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | V | 346 | - | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | H8 | A | 516 | 8x56 | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | ICL2 | R | 352 | - | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | ICL2 | R | 352 | - | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM5 | L | 441 | 5x64 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | L | 441 | 5x64 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | ICL2 | Y | 347 | - | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | Y | 347 | - | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | TM2 | H | 284 | 2x50 | G.H5 | Y | 391 | G.H5.23 |
Polar | ICL2 | N | 348 | - | G.s2s3 | K | 216 | G.s2s3.02 |
Van-der-waals | ICL2 | N | 348 | - | G.s2s3 | K | 216 | G.s2s3.02 |
Hydrophobic | TM5 | L | 441 | 5x64 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM5 | L | 441 | 5x64 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL2 | Y | 347 | - | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | Y | 347 | - | G.H5 | I | 383 | G.H5.15 |
Polar | ICL2 | Y | 347 | - | G.H5 | F | 376 | G.H5.08 |
Aromatic | ICL2 | Y | 347 | - | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | ICL2 | Y | 347 | - | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | ICL2 | Y | 347 | - | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | TM3 | L | 342 | 3x57 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | L | 342 | 3x57 | G.H5 | Y | 391 | G.H5.23 |
Ionic | H8 | E | 513 | 8x53 | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | H8 | E | 513 | 8x53 | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | TM6 | H | 454 | 6x37 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | H | 454 | 6x37 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | H8 | Q | 517 | 8x57 | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | TM6 | H | 454 | 6x37 | G.H5 | L | 393 | G.H5.25 |
Polar | TM6 | T | 458 | 6x41 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | T | 458 | 6x41 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | T | 458 | 6x41 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM5 | L | 438 | 5x61 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM2 | L | 280 | 2x46 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM7 | Q | 506 | 7x60 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM5 | L | 441 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Polar | TM5 | R | 442 | 5x65 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | V | 346 | - | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | ICL2 | V | 346 | - | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | L | 343 | 3x58 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM3 | L | 343 | 3x58 | G.H5 | L | 388 | G.H5.20 |
Aromatic | ICL2 | Y | 347 | - | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | Y | 347 | - | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | Y | 347 | - | G.S1 | H | 41 | G.S1.02 |
Polar | ICL2 | Y | 350 | - | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | ICL2 | Y | 350 | - | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | ICL2 | Y | 350 | - | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | ICL3 | A | 445 | - | G.H5 | R | 385 | G.H5.17 |
Polar | TM3 | G | 344 | 3x59 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | TM3 | G | 344 | 3x59 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL2 | Y | 350 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | Y | 350 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM3 | L | 339 | 3x54 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL3 | A | 445 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Polar | TM7 | Q | 506 | 7x60 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM7 | Q | 506 | 7x60 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM7 | Q | 506 | 7x60 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM6 | L | 465 | 6x48 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM6 | L | 465 | 6x48 | G.H5 | Y | 391 | G.H5.23 |
Polar | ICL2 | R | 352 | - | G.HN | Q | 31 | G.HN.48 |
Van-der-waals | ICL2 | R | 352 | - | G.HN | Q | 31 | G.HN.48 |