Gs - ADGRG6 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Aromatic ICL2 F 963 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 963 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 963 - G.H5 F 376 G.H5.08
Hydrophobic C-term K 1144 - G.H3 W 281 G.H3.17
Van-der-waals C-term K 1144 - G.H3 W 281 G.H3.17
Hydrophobic ICL2 Y 966 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 Y 966 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 V 962 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 R 968 - G.HN Q 35 G.HN.52
Polar TM7 K 1118 7x61 G.H5 Q 390 G.H5.22
Van-der-waals TM7 K 1118 7x61 G.H5 Q 390 G.H5.22
Hydrophobic TM6 S 1072 6x44 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 963 - G.H5 C 379 G.H5.11
Polar ICL2 N 964 - G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 N 964 - G.s2s3 K 216 G.s2s3.02
Hydrophobic TM5 I 1047 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM6 R 1065 6x37 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 1065 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM6 L 1076 6x48 G.H5 Y 391 G.H5.23
Hydrophobic TM5 R 1054 5x68 G.S6 P 361 G.S6.03
Van-der-waals TM5 R 1054 5x68 G.S6 P 361 G.S6.03
Ionic TM6 R 1068 6x40 G.H5 E 392 G.H5.24
Polar TM6 R 1068 6x40 G.H5 E 392 G.H5.24
Hydrophobic TM6 R 1068 6x40 G.H5 E 392 G.H5.24
Hydrophobic TM3 L 959 3x58 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 959 3x58 G.H5 H 387 G.H5.19
Aromatic ICL2 F 963 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 963 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 963 - G.S1 H 41 G.S1.02
Polar TM3 H 954 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 H 954 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 H 954 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 A 958 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 958 3x57 G.H5 H 387 G.H5.19
Hydrophobic ICL2 V 962 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 V 962 - G.H5 I 383 G.H5.15
Hydrophobic TM5 I 1047 5x61 G.H5 L 388 G.H5.20
Polar TM5 R 1050 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 R 1050 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 R 1050 5x64 G.H5 Q 384 G.H5.16
Polar H8 E 1119 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 E 1119 8x48 G.H5 E 392 G.H5.24
Polar ICL2 R 968 - G.HN Q 31 G.HN.48
Hydrophobic ICL2 R 968 - G.HN Q 31 G.HN.48
Van-der-waals ICL2 R 968 - G.HN Q 31 G.HN.48
Polar TM5 R 1050 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 R 1050 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 V 1043 5x57 G.H5 L 393 G.H5.25
Polar TM3 E 951 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 951 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 951 3x50 G.H5 Y 391 G.H5.23
Polar TM3 L 959 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 959 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 959 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM5 R 1050 5x64 G.H5 L 388 G.H5.20
Van-der-waals TM5 R 1050 5x64 G.H5 L 388 G.H5.20
Polar TM3 M 955 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM3 M 955 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 M 955 3x54 G.H5 Y 391 G.H5.23
Ionic C-term D 1141 - G.h4s6 R 356 G.h4s6.12
Polar C-term D 1141 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term D 1141 - G.h4s6 R 356 G.h4s6.12
Aromatic TM5 R 1054 5x68 G.S6 Y 360 G.S6.02
Hydrophobic TM5 R 1054 5x68 G.S6 Y 360 G.S6.02
Hydrophobic TM3 L 959 3x58 G.H5 L 388 G.H5.20
Ionic H8 E 1119 8x48 G.h4s6 R 356 G.h4s6.12
Hydrophobic TM2 P 897 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 P 897 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 P 897 2x46 G.H5 Y 391 G.H5.23
Polar TM5 R 1054 5x68 G.S6 C 359 G.S6.01
Hydrophobic TM5 R 1054 5x68 G.S6 C 359 G.S6.01
Van-der-waals TM5 R 1054 5x68 G.S6 C 359 G.S6.01
Hydrophobic ICL2 V 962 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 V 962 - G.H5 Q 384 G.H5.16
Polar TM6 S 1069 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 1069 6x41 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 963 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 963 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 Y 966 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 Y 966 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 F 963 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 963 - G.H5 I 383 G.H5.15
Hydrophobic TM2 D 895 2x44 G.H5 Q 390 G.H5.22
Hydrophobic TM7 K 1118 7x61 G.H5 E 392 G.H5.24
Van-der-waals TM7 K 1118 7x61 G.H5 E 392 G.H5.24
Van-der-waals ICL3 R 1057 - G.H5 L 394 G.H5.26
Hydrophobic TM5 V 1043 5x57 G.H5 L 388 G.H5.20
Polar TM5 Q 1046 5x60 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Q 1046 5x60 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 F 963 - G.H5 R 380 G.H5.12
Ionic H8 E 1119 8x48 G.H5 R 389 G.H5.21
Polar H8 E 1119 8x48 G.H5 R 389 G.H5.21
Ionic TM5 R 1050 5x64 G.H5 D 381 G.H5.13
Polar TM5 R 1050 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 R 1050 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 R 1050 5x64 G.H5 D 381 G.H5.13