GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Ionic | TM5 | R | 1050 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | R | 1050 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | R | 1050 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | R | 1050 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL2 | V | 962 | - | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM5 | R | 1050 | 5x64 | G.H5 | L | 348 | G.H5.20 |
Ionic | TM5 | K | 1053 | 5x67 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | K | 1053 | 5x67 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | K | 1053 | 5x67 | G.H5 | D | 341 | G.H5.13 |
Ionic | C-term | K | 1144 | - | G.H5 | E | 346 | G.H5.18 |
Polar | C-term | K | 1144 | - | G.H5 | E | 346 | G.H5.18 |
Van-der-waals | C-term | K | 1144 | - | G.H5 | E | 346 | G.H5.18 |
Polar | TM3 | A | 958 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 958 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 958 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Ionic | TM5 | R | 1054 | 5x68 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM5 | R | 1054 | 5x68 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM5 | R | 1054 | 5x68 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM5 | R | 1054 | 5x68 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL2 | V | 962 | - | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | V | 962 | - | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM3 | L | 959 | 3x58 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | Y | 966 | - | G.HN | A | 27 | G.HN.51 |
Van-der-waals | ICL2 | Y | 966 | - | G.HN | A | 27 | G.HN.51 |
Hydrophobic | TM2 | P | 897 | 2x46 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM7 | H | 1114 | 7x57 | G.H5 | L | 353 | G.H5.25 |
Ionic | ICL2 | R | 968 | - | G.HN | E | 20 | G.HN.44 |
Polar | ICL2 | R | 968 | - | G.HN | E | 20 | G.HN.44 |
Van-der-waals | ICL2 | R | 968 | - | G.HN | E | 20 | G.HN.44 |
Polar | TM6 | S | 1069 | 6x41 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | S | 1069 | 6x41 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | S | 1072 | 6x44 | G.H5 | L | 353 | G.H5.25 |
Ionic | H8 | E | 1119 | 8x48 | G.H5 | K | 349 | G.H5.21 |
Polar | H8 | E | 1119 | 8x48 | G.H5 | K | 349 | G.H5.21 |
Hydrophobic | H8 | E | 1119 | 8x48 | G.H5 | K | 349 | G.H5.21 |
Van-der-waals | H8 | E | 1119 | 8x48 | G.H5 | K | 349 | G.H5.21 |
Hydrophobic | TM6 | L | 1073 | 6x45 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | L | 959 | 3x58 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM3 | L | 959 | 3x58 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | V | 1043 | 5x57 | G.H5 | L | 348 | G.H5.20 |
Ionic | TM4 | R | 969 | 4x41 | G.HN | E | 20 | G.HN.44 |
Polar | TM4 | R | 969 | 4x41 | G.HN | E | 20 | G.HN.44 |
Van-der-waals | TM4 | R | 969 | 4x41 | G.HN | E | 20 | G.HN.44 |
Hydrophobic | ICL2 | V | 962 | - | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | V | 962 | - | G.H5 | I | 343 | G.H5.15 |
Polar | ICL2 | R | 968 | - | G.HN | Q | 24 | G.HN.48 |
Hydrophobic | ICL2 | R | 968 | - | G.HN | Q | 24 | G.HN.48 |
Van-der-waals | ICL2 | R | 968 | - | G.HN | Q | 24 | G.HN.48 |
Hydrophobic | TM5 | I | 1047 | 5x61 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | Y | 966 | - | G.HN | Q | 24 | G.HN.48 |
Van-der-waals | ICL2 | Y | 966 | - | G.HN | Q | 24 | G.HN.48 |
Polar | TM7 | K | 1118 | 7x61 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM7 | K | 1118 | 7x61 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM7 | K | 1118 | 7x61 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM5 | V | 1043 | 5x57 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM5 | V | 1043 | 5x57 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | R | 1054 | 5x68 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM5 | R | 1054 | 5x68 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM5 | R | 1054 | 5x68 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM3 | M | 955 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL3 | N | 1056 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | ICL3 | N | 1056 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | ICL3 | N | 1056 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Polar | ICL2 | N | 964 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | N | 964 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | N | 964 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM2 | D | 895 | 2x44 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM3 | L | 959 | 3x58 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | L | 959 | 3x58 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | Y | 966 | - | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | Y | 966 | - | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM2 | P | 897 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | P | 897 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM5 | I | 1047 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | F | 963 | - | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | F | 963 | - | G.H5 | I | 343 | G.H5.15 |
Aromatic | TM6 | R | 1065 | 6x37 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | R | 1065 | 6x37 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | R | 1065 | 6x37 | G.H5 | F | 354 | G.H5.26 |
Ionic | ICL3 | R | 1057 | - | G.h4s6 | E | 315 | G.h4s6.09 |
Polar | ICL3 | R | 1057 | - | G.h4s6 | E | 315 | G.h4s6.09 |
Hydrophobic | ICL3 | R | 1057 | - | G.h4s6 | E | 315 | G.h4s6.09 |
Van-der-waals | ICL3 | R | 1057 | - | G.h4s6 | E | 315 | G.h4s6.09 |
Polar | TM7 | H | 1114 | 7x57 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM5 | Q | 1046 | 5x60 | G.H5 | I | 344 | G.H5.16 |
Polar | ICL2 | N | 964 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL2 | N | 964 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | N | 964 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL2 | Y | 966 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | F | 963 | - | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | F | 963 | - | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | ICL2 | F | 963 | - | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | F | 963 | - | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM5 | R | 1050 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | R | 1050 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Aromatic | ICL2 | F | 963 | - | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | ICL2 | F | 963 | - | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | F | 963 | - | G.H5 | F | 336 | G.H5.08 |