GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL3 | K | 662 | - | G.h4s6 | E | 316 | G.h4s6.09 |
Van-der-waals | ICL3 | K | 662 | - | G.h4s6 | E | 316 | G.h4s6.09 |
Hydrophobic | TM3 | L | 555 | 3x58 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | ICL2 | M | 559 | - | G.S1 | I | 34 | G.S1.02 |
Van-der-waals | ICL2 | M | 559 | - | G.S1 | I | 34 | G.S1.02 |
Polar | C-term | Y | 760 | - | G.H3 | E | 246 | G.H3.04 |
Van-der-waals | C-term | Y | 760 | - | G.H3 | E | 246 | G.H3.04 |
Polar | C-term | Y | 760 | - | G.H2 | R | 209 | G.H2.04 |
Aromatic | C-term | Y | 760 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | ICL3 | L | 658 | - | G.H5 | A | 339 | G.H5.10 |
Van-der-waals | ICL3 | L | 658 | - | G.H5 | A | 339 | G.H5.10 |
Hydrophobic | TM5 | V | 650 | 5x61 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM5 | V | 650 | 5x61 | G.H5 | I | 345 | G.H5.16 |
Polar | C-term | Y | 760 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | ICL3 | L | 658 | - | G.H5 | F | 335 | G.H5.06 |
Polar | TM6 | S | 672 | 6x41 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | S | 672 | 6x41 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | S | 672 | 6x41 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | T | 558 | - | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM7 | Y | 720 | 7x57 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | L | 551 | 3x54 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | L | 551 | 3x54 | G.H5 | I | 352 | G.H5.23 |
Polar | TM5 | N | 655 | 5x66 | G.H5 | D | 338 | G.H5.09 |
Hydrophobic | TM5 | N | 657 | 5x68 | G.H5 | F | 335 | G.H5.06 |
Van-der-waals | TM5 | N | 657 | 5x68 | G.H5 | F | 335 | G.H5.06 |
Hydrophobic | TM7 | Y | 720 | 7x57 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM7 | Y | 720 | 7x57 | G.H5 | I | 352 | G.H5.23 |
Ionic | H8 | K | 725 | 8x48 | G.h4s6 | E | 316 | G.h4s6.09 |
Polar | H8 | K | 725 | 8x48 | G.h4s6 | E | 316 | G.h4s6.09 |
Van-der-waals | H8 | K | 725 | 8x48 | G.h4s6 | E | 316 | G.h4s6.09 |
Hydrophobic | TM6 | S | 675 | 6x44 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | S | 675 | 6x44 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL3 | L | 658 | - | G.H5 | D | 342 | G.H5.13 |
Polar | ICL3 | S | 660 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | ICL3 | S | 660 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | ICL3 | S | 660 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | TM7 | R | 723 | 7x60 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | TM7 | R | 723 | 7x60 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | TM7 | R | 723 | 7x60 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | ICL2 | M | 559 | - | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | M | 559 | - | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | ICL2 | M | 559 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | M | 559 | - | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | ICL2 | P | 561 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | T | 558 | - | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | T | 558 | - | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | TM5 | L | 651 | 5x62 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL3 | L | 658 | - | G.H5 | D | 338 | G.H5.09 |
Hydrophobic | TM2 | V | 467 | 2x46 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | ICL3 | L | 658 | - | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | C-term | R | 764 | - | G.H3 | W | 259 | G.H3.17 |
Van-der-waals | C-term | R | 764 | - | G.H3 | W | 259 | G.H3.17 |
Hydrophobic | C-term | M | 759 | - | G.H3 | N | 256 | G.H3.14 |
Van-der-waals | C-term | M | 759 | - | G.H3 | N | 256 | G.H3.14 |
Van-der-waals | ICL3 | S | 660 | - | G.S6 | I | 320 | G.S6.01 |
Hydrophobic | ICL2 | M | 559 | - | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | ICL2 | M | 559 | - | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | ICL2 | P | 561 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | C-term | F | 762 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | F | 762 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | F | 762 | - | G.H2 | W | 212 | G.H2.07 |
Van-der-waals | C-term | F | 762 | - | G.H2 | W | 212 | G.H2.07 |
Aromatic | C-term | F | 762 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Hydrophobic | C-term | F | 762 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Hydrophobic | TM3 | L | 555 | 3x58 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | ICL1 | K | 464 | - | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | ICL1 | K | 464 | - | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | C-term | R | 764 | - | G.H2 | I | 213 | G.H2.08 |
Hydrophobic | ICL1 | R | 463 | 12x51 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | ICL1 | R | 463 | 12x51 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | C-term | F | 773 | - | G.S2 | I | 185 | G.S2.01 |
Hydrophobic | C-term | F | 762 | - | G.H3 | I | 254 | G.H3.12 |
Polar | TM3 | L | 554 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | L | 554 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | L | 554 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | C-term | M | 759 | - | G.H3 | N | 257 | G.H3.15 |
Hydrophobic | TM6 | V | 676 | 6x45 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | ICL1 | V | 462 | 12x50 | G.H5 | Y | 351 | G.H5.22 |
Polar | C-term | Y | 760 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | C-term | Y | 760 | - | G.H3 | S | 253 | G.H3.11 |
Van-der-waals | C-term | Y | 760 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | TM2 | V | 467 | 2x46 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | ICL3 | S | 660 | - | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | ICL3 | T | 661 | - | G.H4 | E | 309 | G.H4.16 |
Van-der-waals | ICL3 | T | 661 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | TM3 | L | 554 | 3x57 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | ICL2 | M | 559 | - | G.H5 | V | 340 | G.H5.11 |
Hydrophobic | C-term | M | 759 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | C-term | P | 767 | - | G.H2 | H | 214 | G.H2.09 |
Polar | ICL2 | T | 558 | - | G.H5 | N | 348 | G.H5.19 |
Polar | ICL2 | R | 564 | - | G.HN | Q | 28 | G.HN.52 |
Hydrophobic | ICL2 | R | 564 | - | G.HN | Q | 28 | G.HN.52 |
Van-der-waals | ICL2 | R | 564 | - | G.HN | Q | 28 | G.HN.52 |
Polar | ICL1 | K | 464 | - | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL1 | K | 464 | - | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | C-term | L | 763 | - | G.H2 | I | 213 | G.H2.08 |
Van-der-waals | C-term | L | 763 | - | G.H2 | I | 213 | G.H2.08 |
Hydrophobic | TM3 | L | 555 | 3x58 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | ICL3 | T | 659 | - | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | ICL3 | T | 659 | - | G.S6 | Y | 321 | G.S6.02 |
Polar | ICL3 | T | 659 | - | G.S6 | S | 322 | G.S6.03 |
Van-der-waals | ICL3 | T | 659 | - | G.S6 | S | 322 | G.S6.03 |
Hydrophobic | ICL2 | M | 559 | - | G.H5 | F | 337 | G.H5.08 |
Van-der-waals | ICL2 | M | 559 | - | G.H5 | F | 337 | G.H5.08 |
Hydrophobic | TM3 | L | 555 | 3x58 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | L | 555 | 3x58 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL2 | T | 558 | - | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | ICL2 | T | 558 | - | G.H5 | T | 341 | G.H5.12 |
Ionic | ICL2 | K | 560 | - | G.s2s3 | E | 194 | G.s2s3.02 |
Polar | ICL2 | K | 560 | - | G.s2s3 | E | 194 | G.s2s3.02 |
Hydrophobic | ICL2 | K | 560 | - | G.s2s3 | E | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | K | 560 | - | G.s2s3 | E | 194 | G.s2s3.02 |
Hydrophobic | TM3 | L | 551 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Polar | ICL3 | T | 661 | - | G.S6 | I | 320 | G.S6.01 |
Hydrophobic | ICL3 | T | 661 | - | G.S6 | I | 320 | G.S6.01 |
Van-der-waals | ICL3 | T | 661 | - | G.S6 | I | 320 | G.S6.01 |
Hydrophobic | ICL3 | K | 662 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | ICL3 | K | 662 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | C-term | F | 762 | - | G.H2 | I | 213 | G.H2.08 |
Hydrophobic | C-term | M | 759 | - | G.H3 | D | 252 | G.H3.10 |
Van-der-waals | C-term | M | 759 | - | G.H3 | D | 252 | G.H3.10 |
Van-der-waals | TM6 | K | 668 | 6x37 | G.H5 | C | 355 | G.H5.26 |
Polar | TM7 | R | 723 | 7x60 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM7 | R | 723 | 7x60 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM7 | R | 723 | 7x60 | G.H5 | L | 354 | G.H5.25 |