GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 62.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.7
PAE mean: 13.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM5 | L | 1036 | 5x68 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM5 | L | 1036 | 5x68 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM5 | L | 1036 | 5x68 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | ICL2 | F | 956 | - | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | C-term | V | 1157 | - | G.H2 | K | 213 | G.H2.01 |
Polar | C-term | S | 1198 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | C-term | S | 1198 | - | G.S2 | I | 192 | G.S2.01 |
Van-der-waals | C-term | S | 1198 | - | G.S2 | I | 192 | G.S2.01 |
Polar | H8 | K | 1102 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | K | 1102 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | K | 1102 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | Y | 1200 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | C-term | I | 1285 | - | G.HN | L | 32 | G.HN.47 |
Van-der-waals | C-term | I | 1285 | - | G.HN | L | 32 | G.HN.47 |
Hydrophobic | C-term | T | 1161 | - | G.H2 | K | 213 | G.H2.01 |
Hydrophobic | TM5 | M | 1029 | 5x61 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM5 | M | 1029 | 5x61 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | H8 | Q | 1101 | 8x47 | G.H5 | E | 370 | G.H5.22 |
Polar | C-term | Q | 1160 | - | G.H3 | E | 253 | G.H3.04 |
Hydrophobic | C-term | V | 1157 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | V | 1157 | - | G.H2 | K | 217 | G.H2.05 |
Polar | TM6 | S | 1048 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Polar | TM6 | S | 1048 | 6x37 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | ICL2 | E | 959 | - | G.HN | K | 37 | G.HN.52 |
Polar | ICL2 | E | 959 | - | G.S3 | N | 203 | G.S3.02 |
Hydrophobic | C-term | M | 1152 | - | G.H3 | L | 264 | G.H3.15 |
Hydrophobic | ICL2 | F | 956 | - | G.H5 | V | 359 | G.H5.11 |
Van-der-waals | ICL2 | F | 956 | - | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | ICL2 | F | 956 | - | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | C-term | L | 1191 | - | G.h1ha | Y | 70 | G.h1ha.04 |
Van-der-waals | C-term | L | 1191 | - | G.h1ha | Y | 70 | G.h1ha.04 |
Aromatic | C-term | W | 1153 | - | G.h2s4 | F | 223 | G.h2s4.01 |
Hydrophobic | C-term | W | 1153 | - | G.h2s4 | F | 223 | G.h2s4.01 |
Polar | C-term | S | 1163 | - | G.s4h3 | E | 248 | G.s4h3.14 |
Hydrophobic | C-term | W | 1153 | - | G.H2 | W | 219 | G.H2.07 |
Van-der-waals | C-term | W | 1153 | - | G.H2 | W | 219 | G.H2.07 |
Ionic | H8 | K | 1102 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Polar | H8 | K | 1102 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Van-der-waals | H8 | K | 1102 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Hydrophobic | C-term | L | 1191 | - | G.H1 | S | 56 | G.H1.02 |
Polar | C-term | Q | 1160 | - | G.H2 | K | 213 | G.H2.01 |
Hydrophobic | C-term | Q | 1160 | - | G.H2 | K | 213 | G.H2.01 |
Van-der-waals | C-term | Q | 1160 | - | G.H2 | K | 213 | G.H2.01 |
Ionic | H8 | K | 1103 | 8x49 | G.H5 | E | 370 | G.H5.22 |
Polar | H8 | K | 1103 | 8x49 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | H8 | K | 1103 | 8x49 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | H8 | K | 1103 | 8x49 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | C-term | I | 1285 | - | G.HN | I | 28 | G.HN.43 |
Polar | C-term | Q | 1146 | - | G.h2s4 | E | 224 | G.h2s4.02 |
Van-der-waals | C-term | Q | 1146 | - | G.h2s4 | E | 224 | G.h2s4.02 |
Hydrophobic | ICL3 | K | 1037 | - | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | ICL3 | K | 1037 | - | G.H5 | L | 374 | G.H5.26 |
Polar | C-term | W | 1153 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | C-term | W | 1153 | - | G.H2 | R | 216 | G.H2.04 |
Van-der-waals | C-term | W | 1153 | - | G.H2 | R | 216 | G.H2.04 |
Polar | ICL2 | E | 957 | - | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | E | 957 | - | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | E | 957 | - | G.H5 | Y | 367 | G.H5.19 |
Polar | TM7 | L | 1100 | 7x60 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | L | 1100 | 7x60 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM5 | L | 1036 | 5x68 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | C-term | I | 1149 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | C-term | I | 1149 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | C-term | R | 1150 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | C-term | R | 1150 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | C-term | W | 1153 | - | G.H3 | L | 264 | G.H3.15 |
Hydrophobic | C-term | Q | 1192 | - | G.S2 | Y | 195 | G.S2.04 |
Polar | C-term | L | 1185 | - | G.hfs2 | T | 190 | G.hfs2.06 |
Hydrophobic | C-term | L | 1185 | - | G.hfs2 | T | 190 | G.hfs2.06 |
Van-der-waals | C-term | L | 1185 | - | G.hfs2 | T | 190 | G.hfs2.06 |
Hydrophobic | TM5 | S | 1032 | 5x64 | G.H5 | L | 364 | G.H5.16 |
Polar | H8 | Q | 1101 | 8x47 | G.H5 | I | 371 | G.H5.23 |
Polar | C-term | R | 1150 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | C-term | R | 1150 | - | G.H2 | H | 221 | G.H2.09 |
Van-der-waals | C-term | R | 1150 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | C-term | T | 1156 | - | G.H3 | T | 260 | G.H3.11 |
Van-der-waals | C-term | T | 1156 | - | G.H3 | T | 260 | G.H3.11 |
Aromatic | ICL2 | F | 956 | - | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | ICL2 | F | 956 | - | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | F | 956 | - | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | C-term | I | 1149 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | ICL2 | V | 955 | - | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | V | 955 | - | G.H5 | V | 363 | G.H5.15 |
Polar | C-term | Q | 1160 | - | G.H2 | R | 216 | G.H2.04 |
Van-der-waals | C-term | Q | 1160 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | TM6 | G | 1052 | 6x41 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | G | 1052 | 6x41 | G.H5 | L | 373 | G.H5.25 |
Polar | C-term | K | 1282 | - | G.HN | N | 29 | G.HN.44 |
Hydrophobic | C-term | K | 1282 | - | G.HN | N | 29 | G.HN.44 |
Van-der-waals | C-term | K | 1282 | - | G.HN | N | 29 | G.HN.44 |
Polar | H8 | Q | 1101 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | Q | 1101 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | P | 1193 | - | G.S2 | N | 193 | G.S2.02 |
Hydrophobic | C-term | N | 1188 | - | G.hfs2 | M | 187 | G.hfs2.03 |
Van-der-waals | C-term | N | 1188 | - | G.hfs2 | M | 187 | G.hfs2.03 |
Hydrophobic | C-term | W | 1153 | - | G.H2 | I | 220 | G.H2.08 |
Polar | C-term | R | 1194 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | C-term | R | 1194 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | R | 1194 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | C-term | I | 1204 | - | G.H2 | K | 218 | G.H2.06 |
Hydrophobic | ICL2 | V | 955 | - | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | ICL2 | V | 955 | - | G.H5 | L | 364 | G.H5.16 |
Ionic | C-term | E | 1281 | - | G.HN | K | 36 | G.HN.51 |
Polar | C-term | E | 1281 | - | G.HN | K | 36 | G.HN.51 |
Hydrophobic | C-term | E | 1281 | - | G.HN | K | 36 | G.HN.51 |
Van-der-waals | C-term | E | 1281 | - | G.HN | K | 36 | G.HN.51 |
Hydrophobic | C-term | N | 1201 | - | G.hfs2 | G | 191 | G.hfs2.07 |
Van-der-waals | C-term | N | 1201 | - | G.hfs2 | G | 191 | G.hfs2.07 |
Hydrophobic | C-term | K | 1282 | - | G.HN | I | 28 | G.HN.43 |
Van-der-waals | C-term | K | 1282 | - | G.HN | I | 28 | G.HN.43 |
Hydrophobic | TM3 | L | 952 | 3x58 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | C-term | V | 1190 | - | H.HA | F | 78 | H.HA.07 |
Van-der-waals | C-term | V | 1190 | - | H.HA | F | 78 | H.HA.07 |
Polar | C-term | L | 1191 | - | G.S2 | Y | 195 | G.S2.04 |
Hydrophobic | C-term | L | 1191 | - | G.S2 | Y | 195 | G.S2.04 |
Hydrophobic | C-term | P | 1193 | - | G.S2 | Y | 195 | G.S2.04 |
Hydrophobic | C-term | S | 1286 | - | G.HN | I | 28 | G.HN.43 |
Hydrophobic | ICL2 | E | 959 | - | G.hns1 | G | 41 | G.hns1.03 |
Ionic | C-term | R | 1194 | - | G.S1 | E | 42 | G.S1.01 |
Polar | C-term | R | 1194 | - | G.S1 | E | 42 | G.S1.01 |
Hydrophobic | C-term | R | 1194 | - | G.S1 | E | 42 | G.S1.01 |
Van-der-waals | C-term | R | 1194 | - | G.S1 | E | 42 | G.S1.01 |
Hydrophobic | C-term | L | 1191 | - | G.H1 | K | 60 | G.H1.06 |
Polar | C-term | R | 1194 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | C-term | P | 1189 | - | G.hfs2 | M | 187 | G.hfs2.03 |
Hydrophobic | C-term | Y | 1200 | - | G.H2 | C | 222 | G.H2.10 |
Hydrophobic | TM5 | L | 1036 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | C-term | K | 1282 | - | G.HN | L | 32 | G.HN.47 |
Hydrophobic | ICL2 | V | 955 | - | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | V | 955 | - | G.H5 | R | 360 | G.H5.12 |
Polar | C-term | Y | 1200 | - | G.S1 | K | 44 | G.S1.03 |
Hydrophobic | TM3 | L | 951 | 3x57 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | L | 1191 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | C-term | Y | 1200 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | C-term | I | 1285 | - | G.HN | I | 31 | G.HN.46 |
Hydrophobic | TM5 | M | 1029 | 5x61 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM5 | M | 1029 | 5x61 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | C-term | W | 1153 | - | G.H3 | I | 261 | G.H3.12 |
Hydrophobic | ICL2 | F | 956 | - | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | F | 956 | - | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM3 | L | 952 | 3x58 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | L | 952 | 3x58 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM6 | L | 1056 | 6x45 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | V | 1157 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | TM5 | L | 1036 | 5x68 | G.H5 | L | 368 | G.H5.20 |
Polar | C-term | S | 1164 | - | G.H2 | K | 213 | G.H2.01 |
Van-der-waals | C-term | S | 1164 | - | G.H2 | K | 213 | G.H2.01 |
Polar | C-term | N | 1201 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | C-term | N | 1201 | - | G.S2 | I | 192 | G.S2.01 |
Van-der-waals | C-term | N | 1201 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | C-term | L | 1186 | - | G.hfs2 | M | 187 | G.hfs2.03 |
Van-der-waals | C-term | L | 1186 | - | G.hfs2 | M | 187 | G.hfs2.03 |
Polar | H8 | K | 1102 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Polar | C-term | S | 1164 | - | G.s4h3 | E | 248 | G.s4h3.14 |
Hydrophobic | C-term | S | 1164 | - | G.s4h3 | E | 248 | G.s4h3.14 |
Van-der-waals | C-term | S | 1164 | - | G.s4h3 | E | 248 | G.s4h3.14 |
Hydrophobic | C-term | L | 1191 | - | G.H1 | I | 59 | G.H1.05 |
Ionic | C-term | K | 1282 | - | G.HN | D | 25 | G.HN.40 |
Polar | C-term | K | 1282 | - | G.HN | D | 25 | G.HN.40 |
Hydrophobic | C-term | K | 1282 | - | G.HN | D | 25 | G.HN.40 |
Van-der-waals | C-term | K | 1282 | - | G.HN | D | 25 | G.HN.40 |
Hydrophobic | C-term | W | 1153 | - | G.H3 | T | 260 | G.H3.11 |
Polar | C-term | S | 1164 | - | G.s4h3 | N | 245 | G.s4h3.11 |
Hydrophobic | C-term | S | 1164 | - | G.s4h3 | N | 245 | G.s4h3.11 |
Van-der-waals | C-term | S | 1164 | - | G.s4h3 | N | 245 | G.s4h3.11 |
Hydrophobic | C-term | I | 1149 | - | G.H3 | P | 265 | G.H3.16 |
Hydrophobic | C-term | E | 1281 | - | G.HN | L | 32 | G.HN.47 |
Van-der-waals | C-term | E | 1281 | - | G.HN | L | 32 | G.HN.47 |
Hydrophobic | ICL2 | F | 956 | - | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | F | 956 | - | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM5 | L | 1036 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | L | 1036 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Polar | C-term | V | 1190 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | V | 1190 | - | G.H1 | R | 63 | G.H1.09 |
Polar | C-term | Y | 1200 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | C-term | Y | 1200 | - | G.H2 | H | 221 | G.H2.09 |
Van-der-waals | C-term | Y | 1200 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | C-term | W | 1153 | - | G.H3 | L | 257 | G.H3.08 |
Hydrophobic | C-term | P | 1193 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | TM2 | R | 892 | 2x46 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM2 | R | 892 | 2x46 | G.H5 | I | 371 | G.H5.23 |