Gs - ADGRL1 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 64.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.7
PAE mean: 12.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 S 1032 5x64 G.H5 L 394 G.H5.26
Van-der-waals TM5 S 1032 5x64 G.H5 L 394 G.H5.26
Hydrophobic TM6 G 1052 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 G 1052 6x41 G.H5 L 393 G.H5.25
Hydrophobic ICL2 V 955 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 V 955 - G.H5 Q 384 G.H5.16
Polar C-term Q 1469 - G.S2 E 209 G.S2.03
Polar TM3 H 947 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 H 947 3x53 G.H5 Y 391 G.H5.23
Hydrophobic C-term I 1149 - G.H3 W 281 G.H3.17
Van-der-waals C-term I 1149 - G.H3 W 281 G.H3.17
Polar TM3 L 952 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 952 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 952 3x58 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 E 957 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 E 957 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 E 959 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 E 959 - G.HN Q 35 G.HN.52
Polar C-term S 1473 - G.H2 Q 236 G.H2.09
Hydrophobic C-term S 1473 - G.H2 Q 236 G.H2.09
Van-der-waals C-term S 1473 - G.H2 Q 236 G.H2.09
Hydrophobic ICL2 S 958 - G.hns1 A 39 G.hns1.03
Hydrophobic TM5 L 1036 5x68 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 L 1036 5x68 G.h4s6 Y 358 G.h4s6.20
Aromatic ICL2 F 956 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 956 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 956 - G.S1 H 41 G.S1.02
Polar C-term Q 1160 - G.H2 R 228 G.H2.01
Van-der-waals TM7 L 1100 7x60 G.H5 E 392 G.H5.24
Polar C-term S 1164 - G.H2 R 228 G.H2.01
Hydrophobic C-term M 1468 - G.H1 V 57 G.H1.05
Van-der-waals C-term M 1468 - G.H1 V 57 G.H1.05
Hydrophobic C-term W 1153 - G.H3 I 276 G.H3.12
Polar C-term Q 1160 - G.H2 R 231 G.H2.04
Van-der-waals C-term Q 1160 - G.H2 R 231 G.H2.04
Hydrophobic C-term T 1161 - G.H2 R 228 G.H2.01
Van-der-waals C-term L 1470 - G.S2 I 207 G.S2.01
Hydrophobic ICL2 F 956 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 956 - G.H5 I 383 G.H5.15
Hydrophobic TM6 L 1056 6x45 G.H5 L 393 G.H5.25
Van-der-waals C-term M 1468 - G.S2 E 209 G.S2.03
Hydrophobic ICL3 K 1037 - G.h4s6 G 355 G.h4s6.11
Hydrophobic C-term W 1153 - G.H2 I 235 G.H2.08
Van-der-waals C-term W 1153 - G.H2 I 235 G.H2.08
Polar H8 Q 1101 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 Q 1101 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 Q 1101 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 E 959 - G.hns1 A 39 G.hns1.03
Hydrophobic C-term T 1156 - G.H3 S 275 G.H3.11
Hydrophobic C-term V 1157 - G.H2 R 232 G.H2.05
Hydrophobic TM5 L 1036 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 L 1036 5x68 G.H5 R 385 G.H5.17
Polar ICL2 S 958 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 S 958 - G.HN Q 35 G.HN.52
Polar C-term V 1471 - G.S2 I 207 G.S2.01
Hydrophobic C-term V 1471 - G.S2 I 207 G.S2.01
Van-der-waals C-term V 1471 - G.S2 I 207 G.S2.01
Polar ICL2 E 957 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 E 957 - G.HN Q 35 G.HN.52
Polar H8 K 1103 8x49 G.H5 Q 390 G.H5.22
Hydrophobic H8 K 1103 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 K 1103 8x49 G.H5 Q 390 G.H5.22
Polar TM3 L 951 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 951 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 951 3x57 G.H5 H 387 G.H5.19
Polar TM5 K 1028 5x60 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 1028 5x60 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 1028 5x60 G.H5 Q 384 G.H5.16
Hydrophobic C-term V 1157 - G.H2 R 231 G.H2.04
Polar C-term Q 1469 - G.S2 K 211 G.S2.05
Hydrophobic C-term W 1153 - G.H2 W 234 G.H2.07
Van-der-waals C-term W 1153 - G.H2 W 234 G.H2.07
Hydrophobic ICL2 F 956 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 956 - G.H5 R 380 G.H5.12
Hydrophobic C-term M 1152 - G.H3 W 281 G.H3.17
Van-der-waals C-term M 1152 - G.H3 W 281 G.H3.17
Hydrophobic C-term W 1153 - G.H3 N 279 G.H3.15
Van-der-waals C-term W 1153 - G.H3 N 279 G.H3.15
Hydrophobic TM5 M 1029 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM3 L 948 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 948 3x54 G.H5 Y 391 G.H5.23
Hydrophobic C-term W 1153 - G.H2 R 232 G.H2.05
Hydrophobic C-term L 1470 - G.S2 F 208 G.S2.02
Hydrophobic C-term Q 1160 - G.H3 L 272 G.H3.08
Polar C-term Q 1160 - G.H3 S 275 G.H3.11
Van-der-waals C-term Q 1160 - G.H3 S 275 G.H3.11
Polar C-term W 1153 - G.H2 R 231 G.H2.04
Van-der-waals C-term W 1153 - G.H2 R 231 G.H2.04
Ionic ICL2 E 957 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 E 957 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 E 957 - G.hns1 R 38 G.hns1.02
Hydrophobic TM5 T 1025 5x57 G.H5 L 393 G.H5.25
Aromatic ICL2 F 956 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 956 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 956 - G.H5 F 376 G.H5.08
Hydrophobic TM5 S 1032 5x64 G.H5 L 388 G.H5.20
Van-der-waals TM5 S 1032 5x64 G.H5 L 388 G.H5.20
Ionic H8 K 1102 8x48 G.H5 E 392 G.H5.24
Polar H8 K 1102 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 1102 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 1102 8x48 G.H5 E 392 G.H5.24
Polar H8 Q 1101 8x47 G.H5 Y 391 G.H5.23
Polar ICL2 E 959 - G.S3 N 218 G.S3.02
Van-der-waals ICL2 E 959 - G.S3 N 218 G.S3.02
Hydrophobic TM3 L 952 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 952 3x58 G.H5 L 388 G.H5.20
Hydrophobic C-term R 1150 - G.H2 I 235 G.H2.08
Van-der-waals C-term R 1150 - G.H2 I 235 G.H2.08
Hydrophobic ICL2 F 956 - G.H5 C 379 G.H5.11
Hydrophobic ICL2 V 955 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 V 955 - G.H5 R 380 G.H5.12
Hydrophobic C-term I 1149 - G.H2 I 235 G.H2.08
Van-der-waals C-term I 1149 - G.H2 I 235 G.H2.08
Hydrophobic C-term M 1468 - G.S2 T 210 G.S2.04
Van-der-waals C-term M 1468 - G.S2 T 210 G.S2.04
Polar TM2 R 892 2x46 G.H5 Y 391 G.H5.23
Aromatic TM2 R 892 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 892 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 892 2x46 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 956 - G.S3 F 219 G.S3.03
Hydrophobic C-term V 1471 - G.S3 F 222 G.S3.06
Hydrophobic C-term M 1468 - G.H1 R 61 G.H1.09
Hydrophobic C-term V 1471 - G.S2 E 209 G.S2.03
Polar ICL2 V 955 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 V 955 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 V 955 - G.H5 H 387 G.H5.19
Hydrophobic C-term M 1152 - G.H3 R 280 G.H3.16
Hydrophobic ICL2 F 956 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 956 - G.S3 V 217 G.S3.01
Hydrophobic TM3 L 951 3x57 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 951 3x57 G.H5 Y 391 G.H5.23
Hydrophobic TM5 M 1029 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 M 1029 5x61 G.H5 L 393 G.H5.25
Aromatic C-term W 1153 - G.h2s4 F 238 G.h2s4.01
Hydrophobic C-term W 1153 - G.h2s4 F 238 G.h2s4.01
Van-der-waals C-term W 1153 - G.h2s4 F 238 G.h2s4.01
Hydrophobic TM5 S 1032 5x64 G.H5 R 385 G.H5.17
Hydrophobic ICL2 V 955 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 V 955 - G.H5 I 383 G.H5.15