GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 62.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.7
PAE mean: 16.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | L | 1036 | 5x68 | G.H5 | A | 338 | G.H5.10 |
Van-der-waals | TM5 | L | 1036 | 5x68 | G.H5 | A | 338 | G.H5.10 |
Hydrophobic | ICL2 | V | 955 | - | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | V | 955 | - | G.H5 | I | 344 | G.H5.16 |
Polar | C-term | N | 1138 | - | G.H4 | Q | 306 | G.H4.14 |
Van-der-waals | C-term | N | 1138 | - | G.H4 | Q | 306 | G.H4.14 |
Polar | C-term | R | 1140 | - | G.H3 | H | 244 | G.H3.03 |
Aromatic | C-term | R | 1140 | - | G.H3 | H | 244 | G.H3.03 |
Hydrophobic | C-term | R | 1140 | - | G.H3 | H | 244 | G.H3.03 |
Van-der-waals | C-term | R | 1140 | - | G.H3 | H | 244 | G.H3.03 |
Ionic | ICL2 | E | 959 | - | G.hns1 | R | 32 | G.hns1.03 |
Polar | ICL2 | E | 959 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | E | 959 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | E | 959 | - | G.hns1 | R | 32 | G.hns1.03 |
Polar | C-term | T | 1145 | - | G.H3 | H | 248 | G.H3.07 |
Hydrophobic | C-term | T | 1145 | - | G.H3 | H | 248 | G.H3.07 |
Van-der-waals | C-term | T | 1145 | - | G.H3 | H | 248 | G.H3.07 |
Polar | C-term | R | 1150 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | TM5 | M | 1029 | 5x61 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | I | 1149 | - | G.H3 | L | 249 | G.H3.08 |
Hydrophobic | TM3 | L | 952 | 3x58 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM3 | L | 952 | 3x58 | G.H5 | I | 344 | G.H5.16 |
Polar | C-term | E | 1342 | - | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | C-term | E | 1342 | - | G.H3 | K | 257 | G.H3.16 |
Aromatic | C-term | W | 1153 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | C-term | W | 1153 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Polar | ICL2 | E | 959 | - | G.HN | R | 29 | G.HN.53 |
Polar | TM3 | L | 951 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | L | 951 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | L | 951 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Polar | TM2 | R | 892 | 2x46 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM5 | V | 1035 | 5x67 | G.H5 | F | 334 | G.H5.06 |
Ionic | ICL3 | D | 1039 | - | G.H4 | K | 304 | G.H4.12 |
Polar | ICL3 | D | 1039 | - | G.H4 | K | 304 | G.H4.12 |
Van-der-waals | ICL3 | D | 1039 | - | G.H4 | K | 304 | G.H4.12 |
Polar | C-term | Y | 1142 | - | G.h4s6 | L | 310 | G.h4s6.01 |
Hydrophobic | C-term | Y | 1142 | - | G.h4s6 | L | 310 | G.h4s6.01 |
Van-der-waals | C-term | Y | 1142 | - | G.h4s6 | L | 310 | G.h4s6.01 |
Hydrophobic | ICL2 | F | 956 | - | G.S1 | V | 34 | G.S1.02 |
Van-der-waals | ICL2 | F | 956 | - | G.S1 | V | 34 | G.S1.02 |
Hydrophobic | TM5 | L | 1036 | 5x68 | G.H5 | I | 342 | G.H5.14 |
Van-der-waals | TM5 | L | 1036 | 5x68 | G.H5 | I | 342 | G.H5.14 |
Hydrophobic | TM5 | S | 1032 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | S | 1032 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Polar | C-term | Q | 1160 | - | G.H2 | H | 213 | G.H2.09 |
Hydrophobic | C-term | Q | 1160 | - | G.H2 | H | 213 | G.H2.09 |
Van-der-waals | C-term | Q | 1160 | - | G.H2 | H | 213 | G.H2.09 |
Hydrophobic | C-term | W | 1153 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | TM6 | L | 1056 | 6x45 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | L | 1056 | 6x45 | G.H5 | L | 353 | G.H5.25 |
Ionic | H8 | K | 1102 | 8x48 | G.h4s6 | D | 316 | G.h4s6.10 |
Polar | H8 | K | 1102 | 8x48 | G.h4s6 | D | 316 | G.h4s6.10 |
Van-der-waals | H8 | K | 1102 | 8x48 | G.h4s6 | D | 316 | G.h4s6.10 |
Hydrophobic | C-term | W | 1153 | - | G.H3 | I | 253 | G.H3.12 |
Van-der-waals | C-term | W | 1153 | - | G.H3 | I | 253 | G.H3.12 |
Hydrophobic | C-term | Y | 1142 | - | G.H3 | N | 251 | G.H3.10 |
Van-der-waals | C-term | Y | 1142 | - | G.H3 | N | 251 | G.H3.10 |
Polar | C-term | Q | 1146 | - | G.H3 | N | 251 | G.H3.10 |
Hydrophobic | C-term | Q | 1146 | - | G.H3 | N | 251 | G.H3.10 |
Van-der-waals | C-term | Q | 1146 | - | G.H3 | N | 251 | G.H3.10 |
Hydrophobic | TM5 | L | 1036 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL2 | V | 955 | - | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | TM5 | V | 1035 | 5x67 | G.H5 | A | 338 | G.H5.10 |
Van-der-waals | TM5 | V | 1035 | 5x67 | G.H5 | A | 338 | G.H5.10 |
Hydrophobic | C-term | V | 1157 | - | G.H2 | I | 212 | G.H2.08 |
Van-der-waals | C-term | V | 1157 | - | G.H2 | I | 212 | G.H2.08 |
Polar | H8 | Q | 1101 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | H8 | Q | 1101 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | Q | 1101 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Polar | TM2 | R | 892 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | R | 892 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | R | 892 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | Y | 1141 | - | G.H3 | L | 247 | G.H3.06 |
Van-der-waals | C-term | Y | 1141 | - | G.H3 | L | 247 | G.H3.06 |
Hydrophobic | TM5 | M | 1029 | 5x61 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM5 | M | 1029 | 5x61 | G.H5 | F | 354 | G.H5.26 |
Polar | C-term | Y | 1141 | - | G.H3 | H | 248 | G.H3.07 |
Aromatic | C-term | Y | 1141 | - | G.H3 | H | 248 | G.H3.07 |
Hydrophobic | C-term | Y | 1141 | - | G.H3 | H | 248 | G.H3.07 |
Van-der-waals | C-term | Y | 1141 | - | G.H3 | H | 248 | G.H3.07 |
Polar | C-term | R | 1150 | - | G.H3 | N | 255 | G.H3.14 |
Hydrophobic | C-term | R | 1150 | - | G.H3 | N | 255 | G.H3.14 |
Van-der-waals | C-term | R | 1150 | - | G.H3 | N | 255 | G.H3.14 |
Hydrophobic | TM5 | L | 1036 | 5x68 | G.H5 | K | 345 | G.H5.17 |
Polar | H8 | K | 1102 | 8x48 | G.h4s6 | E | 315 | G.h4s6.09 |
Van-der-waals | H8 | K | 1102 | 8x48 | G.h4s6 | E | 315 | G.h4s6.09 |
Hydrophobic | C-term | R | 1150 | - | G.H3 | H | 256 | G.H3.15 |
Polar | C-term | R | 1150 | - | G.H3 | N | 251 | G.H3.10 |
Hydrophobic | C-term | T | 1156 | - | G.H2 | I | 212 | G.H2.08 |
Van-der-waals | C-term | T | 1156 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | TM5 | L | 1036 | 5x68 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | ICL2 | V | 955 | - | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | E | 957 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM3 | L | 948 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Ionic | H8 | K | 1103 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Polar | H8 | K | 1103 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | H8 | K | 1103 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | H8 | K | 1103 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Polar | C-term | L | 1340 | - | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | C-term | L | 1340 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | C-term | I | 1149 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | C-term | T | 1156 | - | G.H2 | H | 213 | G.H2.09 |
Ionic | H8 | K | 1106 | 8x52 | G.h4s6 | D | 316 | G.h4s6.10 |
Polar | H8 | K | 1106 | 8x52 | G.h4s6 | D | 316 | G.h4s6.10 |
Hydrophobic | H8 | K | 1106 | 8x52 | G.h4s6 | D | 316 | G.h4s6.10 |
Van-der-waals | H8 | K | 1106 | 8x52 | G.h4s6 | D | 316 | G.h4s6.10 |
Hydrophobic | ICL2 | Y | 960 | - | G.HN | Q | 24 | G.HN.48 |
Aromatic | C-term | W | 1153 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | C-term | W | 1153 | - | G.H3 | H | 256 | G.H3.15 |
Polar | ICL2 | V | 955 | - | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | V | 955 | - | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | V | 955 | - | G.H5 | N | 347 | G.H5.19 |
Polar | ICL2 | Y | 960 | - | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL2 | Y | 960 | - | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | Y | 960 | - | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL2 | F | 956 | - | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | F | 956 | - | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | TM3 | L | 948 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Polar | C-term | Y | 1141 | - | G.H3 | H | 244 | G.H3.03 |
Hydrophobic | C-term | Y | 1141 | - | G.H3 | H | 244 | G.H3.03 |
Van-der-waals | C-term | Y | 1141 | - | G.H3 | H | 244 | G.H3.03 |
Hydrophobic | TM5 | T | 1025 | 5x57 | G.H5 | L | 353 | G.H5.25 |
Polar | C-term | Y | 1141 | - | G.H3 | N | 251 | G.H3.10 |
Van-der-waals | C-term | Y | 1141 | - | G.H3 | N | 251 | G.H3.10 |
Hydrophobic | C-term | Y | 1142 | - | G.h4s6 | L | 312 | G.h4s6.03 |
Van-der-waals | C-term | Y | 1142 | - | G.h4s6 | L | 312 | G.h4s6.03 |
Hydrophobic | C-term | M | 1152 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | C-term | W | 1153 | - | G.H2 | W | 211 | G.H2.07 |
Van-der-waals | C-term | W | 1153 | - | G.H2 | W | 211 | G.H2.07 |
Polar | C-term | W | 1153 | - | G.H2 | R | 208 | G.H2.04 |
Van-der-waals | C-term | W | 1153 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | C-term | W | 1153 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | C-term | Y | 1141 | - | G.h4s6 | L | 310 | G.h4s6.01 |
Van-der-waals | C-term | Y | 1141 | - | G.h4s6 | L | 310 | G.h4s6.01 |
Ionic | ICL3 | K | 1037 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | ICL3 | K | 1037 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | K | 1037 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | K | 1037 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | R | 1140 | - | G.H3 | H | 248 | G.H3.07 |
Van-der-waals | C-term | R | 1140 | - | G.H3 | H | 248 | G.H3.07 |
Hydrophobic | TM3 | L | 948 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | M | 1152 | - | G.H2 | R | 208 | G.H2.04 |
Van-der-waals | C-term | M | 1152 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | ICL2 | F | 956 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | F | 956 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM6 | S | 1048 | 6x37 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | S | 1048 | 6x37 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | L | 1344 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | C-term | L | 1344 | - | G.H3 | Y | 258 | G.H3.17 |
Van-der-waals | C-term | L | 1344 | - | G.H3 | Y | 258 | G.H3.17 |
Hydrophobic | TM3 | L | 952 | 3x58 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | L | 952 | 3x58 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | F | 956 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | F | 956 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | C-term | Q | 1146 | - | G.H3 | S | 252 | G.H3.11 |
Van-der-waals | C-term | Q | 1146 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | TM5 | T | 1025 | 5x57 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | E | 959 | - | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | E | 959 | - | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL2 | F | 956 | - | G.S1 | T | 33 | G.S1.01 |
Van-der-waals | ICL2 | F | 956 | - | G.S1 | T | 33 | G.S1.01 |
Polar | C-term | Y | 1142 | - | G.H4 | D | 309 | G.H4.17 |
Hydrophobic | TM3 | L | 951 | 3x57 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | L | 951 | 3x57 | G.H5 | C | 351 | G.H5.23 |