G12 - ADGRL2 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 64.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.7
PAE mean: 12.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 939 3x58 G.H5 L 375 G.H5.20
Van-der-waals TM3 L 939 3x58 G.H5 L 375 G.H5.20
Hydrophobic C-term E 1266 - G.HN A 36 G.HN.36
Van-der-waals C-term E 1266 - G.HN A 36 G.HN.36
Hydrophobic TM7 F 1083 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 1083 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM5 H 1019 5x64 G.H5 L 371 G.H5.16
Van-der-waals TM5 H 1019 5x64 G.H5 L 371 G.H5.16
Van-der-waals ICL2 S 945 - G.HN R 52 G.HN.52
Polar ICL1 Q 876 12x51 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 L 935 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 935 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 V 942 - G.H5 L 371 G.H5.16
Van-der-waals ICL2 V 942 - G.H5 L 371 G.H5.16
Hydrophobic ICL2 V 942 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 V 942 - G.H5 I 370 G.H5.15
Hydrophobic ICL2 E 946 - G.HN R 52 G.HN.52
Hydrophobic C-term I 1136 - G.h2s4 F 242 G.h2s4.01
Van-der-waals C-term I 1136 - G.h2s4 F 242 G.h2s4.01
Hydrophobic H8 K 1089 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 1089 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM5 L 1023 5x68 G.H5 K 376 G.H5.21
Van-der-waals TM5 L 1023 5x68 G.H5 K 376 G.H5.21
Hydrophobic C-term M 1262 - G.HN R 39 G.HN.39
Van-der-waals C-term M 1262 - G.HN R 39 G.HN.39
Aromatic C-term W 1140 - G.h2s4 F 242 G.h2s4.01
Hydrophobic C-term W 1140 - G.h2s4 F 242 G.h2s4.01
Van-der-waals C-term W 1140 - G.h2s4 F 242 G.h2s4.01
Polar TM3 E 941 3x60 G.H5 K 367 G.H5.12
Hydrophobic TM3 E 941 3x60 G.H5 K 367 G.H5.12
Van-der-waals TM3 E 941 3x60 G.H5 K 367 G.H5.12
Hydrophobic TM5 T 1022 5x67 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM5 T 1022 5x67 G.h4s6 P 345 G.h4s6.20
Hydrophobic C-term I 1136 - G.H2 F 239 G.H2.08
Van-der-waals C-term I 1136 - G.H2 F 239 G.H2.08
Polar ICL3 D 1026 - G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL3 D 1026 - G.h4s6 S 343 G.h4s6.12
Van-der-waals ICL3 D 1026 - G.h4s6 S 343 G.h4s6.12
Polar C-term W 1140 - G.H2 R 235 G.H2.04
Van-der-waals C-term W 1140 - G.H2 R 235 G.H2.04
Hydrophobic ICL2 F 943 - G.H5 K 367 G.H5.12
Hydrophobic C-term M 1139 - G.H3 N 283 G.H3.15
Van-der-waals C-term M 1139 - G.H3 N 283 G.H3.15
Hydrophobic TM5 H 1019 5x64 G.H5 L 375 G.H5.20
Ionic TM5 H 1019 5x64 G.H5 D 368 G.H5.13
Polar TM5 H 1019 5x64 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 1019 5x64 G.H5 D 368 G.H5.13
Van-der-waals TM5 H 1019 5x64 G.H5 D 368 G.H5.13
Polar ICL2 V 942 - G.H5 N 374 G.H5.19
Hydrophobic C-term R 1137 - G.H2 F 239 G.H2.08
Van-der-waals C-term R 1137 - G.H2 F 239 G.H2.08
Hydrophobic C-term Q 1147 - G.H3 I 276 G.H3.08
Van-der-waals C-term Q 1147 - G.H3 I 276 G.H3.08
Hydrophobic C-term V 1144 - G.H2 Q 236 G.H2.05
Hydrophobic C-term W 1140 - G.H3 I 280 G.H3.12
Van-der-waals C-term W 1140 - G.H3 I 280 G.H3.12
Hydrophobic C-term L 1226 - H.HA K 114 H.HA.28
Van-der-waals C-term L 1226 - H.HA K 114 H.HA.28
Ionic TM2 D 878 2x45 G.HN R 52 G.HN.52
Polar TM2 D 878 2x45 G.HN R 52 G.HN.52
Van-der-waals TM2 D 878 2x45 G.HN R 52 G.HN.52
Polar ICL3 K 1024 - G.H5 Q 381 G.H5.26
Hydrophobic ICL3 K 1024 - G.H5 Q 381 G.H5.26
Van-der-waals ICL3 K 1024 - G.H5 Q 381 G.H5.26
Polar TM6 S 1035 6x37 G.H5 M 379 G.H5.24
Hydrophobic TM6 S 1035 6x37 G.H5 M 379 G.H5.24
Van-der-waals TM6 S 1035 6x37 G.H5 M 379 G.H5.24
Ionic C-term D 1156 - G.s4h3 R 266 G.s4h3.13
Polar C-term D 1156 - G.s4h3 R 266 G.s4h3.13
Van-der-waals C-term D 1156 - G.s4h3 R 266 G.s4h3.13
Ionic ICL2 E 944 - G.hns1 R 55 G.hns1.02
Polar ICL2 E 944 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 E 944 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 E 944 - G.hns1 R 55 G.hns1.02
Polar H8 Q 1088 8x47 G.H5 D 377 G.H5.22
Van-der-waals H8 Q 1088 8x47 G.H5 D 377 G.H5.22
Hydrophobic H8 Q 1088 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 Q 1088 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM6 G 1039 6x41 G.H5 M 379 G.H5.24
Van-der-waals TM6 G 1039 6x41 G.H5 M 379 G.H5.24
Polar ICL2 E 944 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 E 944 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 E 944 - G.hns1 R 56 G.hns1.03
Polar C-term Q 1147 - G.H2 R 235 G.H2.04
Van-der-waals C-term Q 1147 - G.H2 R 235 G.H2.04
Hydrophobic C-term I 1136 - G.H3 L 285 G.H3.17
Van-der-waals C-term I 1136 - G.H3 L 285 G.H3.17
Hydrophobic ICL2 V 942 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 V 942 - G.H5 K 367 G.H5.12
Polar C-term Q 1133 - G.H2 Q 240 G.H2.09
Polar C-term Q 1147 - G.H3 N 275 G.H3.07
Hydrophobic C-term Q 1147 - G.H3 N 275 G.H3.07
Van-der-waals C-term Q 1147 - G.H3 N 275 G.H3.07
Hydrophobic ICL2 F 943 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 943 - G.H5 I 370 G.H5.15
Polar C-term Y 1234 - H.HB E 135 H.HB.13
Hydrophobic C-term T 1143 - G.H3 T 279 G.H3.11
Van-der-waals C-term T 1143 - G.H3 T 279 G.H3.11
Polar TM5 T 1022 5x67 G.H5 Q 372 G.H5.17
Van-der-waals TM5 T 1022 5x67 G.H5 Q 372 G.H5.17
Polar TM3 V 940 3x59 G.H5 K 367 G.H5.12
Van-der-waals TM3 V 940 3x59 G.H5 K 367 G.H5.12
Polar TM6 S 1035 6x37 G.H5 Q 381 G.H5.26
Van-der-waals TM6 S 1035 6x37 G.H5 Q 381 G.H5.26
Hydrophobic TM3 L 939 3x58 G.H5 I 378 G.H5.23
Hydrophobic ICL3 P 1025 - G.h4s6 S 343 G.h4s6.12
Van-der-waals ICL3 P 1025 - G.h4s6 S 343 G.h4s6.12
Polar ICL3 D 1026 - G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL3 D 1026 - G.h4s6 R 342 G.h4s6.11
Van-der-waals ICL3 D 1026 - G.h4s6 R 342 G.h4s6.11
Ionic ICL2 E 944 - G.HN R 52 G.HN.52
Ionic H8 K 1090 8x49 G.H5 D 377 G.H5.22
Polar H8 K 1090 8x49 G.H5 D 377 G.H5.22
Hydrophobic H8 K 1090 8x49 G.H5 D 377 G.H5.22
Van-der-waals H8 K 1090 8x49 G.H5 D 377 G.H5.22
Hydrophobic ICL2 F 943 - G.S1 V 58 G.S1.02
Van-der-waals ICL2 F 943 - G.S1 V 58 G.S1.02
Hydrophobic TM5 M 1016 5x61 G.H5 L 375 G.H5.20
Van-der-waals TM5 M 1016 5x61 G.H5 L 375 G.H5.20
Hydrophobic C-term W 1140 - G.H2 F 239 G.H2.08
Hydrophobic C-term L 1455 - G.H5 F 361 G.H5.06
Hydrophobic TM6 W 1036 6x38 G.H5 M 379 G.H5.24
Van-der-waals TM6 W 1036 6x38 G.H5 M 379 G.H5.24
Hydrophobic TM7 L 1087 7x60 G.H5 L 380 G.H5.25
Hydrophobic TM5 M 1016 5x61 G.H5 M 379 G.H5.24
Van-der-waals TM5 M 1016 5x61 G.H5 M 379 G.H5.24
Polar C-term N 1232 - H.HB E 135 H.HB.13
Hydrophobic C-term W 1140 - G.H3 T 279 G.H3.11
Van-der-waals C-term W 1140 - G.H3 T 279 G.H3.11
Hydrophobic TM3 L 939 3x58 G.H5 L 371 G.H5.16
Van-der-waals TM3 L 939 3x58 G.H5 L 371 G.H5.16
Hydrophobic C-term M 1139 - G.H3 L 285 G.H3.17
Van-der-waals C-term M 1139 - G.H3 L 285 G.H3.17
Aromatic ICL2 F 943 - G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 943 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 943 - G.H5 F 363 G.H5.08
Polar ICL2 S 948 - G.HN R 52 G.HN.52
Hydrophobic ICL2 S 948 - G.HN R 52 G.HN.52
Van-der-waals ICL2 S 948 - G.HN R 52 G.HN.52
Hydrophobic ICL2 S 945 - G.hns1 R 56 G.hns1.03
Polar ICL1 Q 876 12x51 G.HN R 51 G.HN.51
Hydrophobic TM5 L 1023 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 L 1023 5x68 G.H5 Q 372 G.H5.17
Ionic ICL2 E 946 - G.hns1 R 56 G.hns1.03
Polar ICL2 E 946 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 E 946 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 E 946 - G.hns1 R 56 G.hns1.03
Hydrophobic C-term W 1140 - G.H2 W 238 G.H2.07
Van-der-waals C-term W 1140 - G.H2 W 238 G.H2.07
Polar TM3 M 938 3x57 G.H5 N 374 G.H5.19
Hydrophobic TM3 M 938 3x57 G.H5 N 374 G.H5.19
Van-der-waals TM3 M 938 3x57 G.H5 N 374 G.H5.19
Hydrophobic ICL2 F 943 - G.H5 V 366 G.H5.11
Hydrophobic ICL2 F 943 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 943 - G.S3 I 221 G.S3.01
Hydrophobic TM6 L 1043 6x45 G.H5 I 378 G.H5.23
Polar TM2 R 879 2x46 G.H5 D 377 G.H5.22
Polar ICL2 Y 947 - G.HN R 52 G.HN.52
Hydrophobic ICL2 Y 947 - G.HN R 52 G.HN.52
Hydrophobic TM2 R 879 2x46 G.H5 I 378 G.H5.23
Hydrophobic TM3 M 938 3x57 G.H5 I 378 G.H5.23
Hydrophobic TM5 L 1023 5x68 G.H5 L 375 G.H5.20