GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 62.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.7
PAE mean: 12.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | C-term | Q | 1147 | - | G.H3 | E | 253 | G.H3.04 |
Hydrophobic | C-term | Q | 1147 | - | G.H3 | E | 253 | G.H3.04 |
Van-der-waals | C-term | Q | 1147 | - | G.H3 | E | 253 | G.H3.04 |
Polar | C-term | S | 1151 | - | G.s4h3 | N | 245 | G.s4h3.11 |
Van-der-waals | C-term | S | 1151 | - | G.s4h3 | N | 245 | G.s4h3.11 |
Polar | C-term | K | 1261 | - | G.HN | N | 29 | G.HN.44 |
Hydrophobic | C-term | K | 1261 | - | G.HN | N | 29 | G.HN.44 |
Van-der-waals | C-term | K | 1261 | - | G.HN | N | 29 | G.HN.44 |
Hydrophobic | TM3 | L | 935 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM5 | H | 1019 | 5x64 | G.H5 | L | 364 | G.H5.16 |
Polar | H8 | K | 1089 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | H8 | K | 1089 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM3 | L | 939 | 3x58 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM5 | M | 1016 | 5x61 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM5 | M | 1016 | 5x61 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM3 | M | 938 | 3x57 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | M | 938 | 3x57 | G.H5 | Y | 367 | G.H5.19 |
Polar | C-term | Q | 1147 | - | G.H2 | R | 216 | G.H2.04 |
Van-der-waals | C-term | Q | 1147 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | C-term | W | 1140 | - | G.H3 | T | 260 | G.H3.11 |
Hydrophobic | C-term | W | 1140 | - | G.H2 | W | 219 | G.H2.07 |
Van-der-waals | C-term | W | 1140 | - | G.H2 | W | 219 | G.H2.07 |
Hydrophobic | ICL2 | E | 946 | - | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | E | 946 | - | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | ICL2 | V | 942 | - | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | V | 942 | - | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | C-term | S | 1148 | - | G.H2 | K | 213 | G.H2.01 |
Hydrophobic | TM5 | H | 1019 | 5x64 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | C-term | I | 1264 | - | G.HN | L | 32 | G.HN.47 |
Ionic | H8 | K | 1089 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Polar | H8 | K | 1089 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Van-der-waals | H8 | K | 1089 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Hydrophobic | ICL2 | E | 946 | - | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | E | 946 | - | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | C-term | T | 1143 | - | G.H3 | T | 260 | G.H3.11 |
Van-der-waals | C-term | T | 1143 | - | G.H3 | T | 260 | G.H3.11 |
Hydrophobic | TM3 | M | 938 | 3x57 | G.H5 | I | 371 | G.H5.23 |
Polar | ICL3 | K | 1024 | - | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL3 | K | 1024 | - | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | ICL3 | K | 1024 | - | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL3 | K | 1024 | - | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | ICL3 | K | 1024 | - | G.H5 | L | 374 | G.H5.26 |
Ionic | H8 | K | 1090 | 8x49 | G.H5 | E | 370 | G.H5.22 |
Polar | H8 | K | 1090 | 8x49 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | H8 | K | 1090 | 8x49 | G.H5 | E | 370 | G.H5.22 |
Aromatic | C-term | W | 1140 | - | G.h2s4 | F | 223 | G.h2s4.01 |
Hydrophobic | C-term | W | 1140 | - | G.h2s4 | F | 223 | G.h2s4.01 |
Hydrophobic | ICL2 | F | 943 | - | G.H5 | V | 359 | G.H5.11 |
Hydrophobic | C-term | V | 1144 | - | G.H2 | K | 213 | G.H2.01 |
Van-der-waals | C-term | V | 1144 | - | G.H2 | K | 213 | G.H2.01 |
Polar | ICL2 | Y | 947 | - | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | ICL2 | Y | 947 | - | G.hns1 | G | 41 | G.hns1.03 |
Van-der-waals | ICL2 | Y | 947 | - | G.hns1 | G | 41 | G.hns1.03 |
Polar | H8 | K | 1089 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | K | 1089 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | K | 1089 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM5 | M | 1016 | 5x61 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM5 | M | 1016 | 5x61 | G.H5 | L | 373 | G.H5.25 |
Polar | ICL2 | S | 945 | - | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | S | 945 | - | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | S | 945 | - | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | I | 1136 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | C-term | I | 1136 | - | G.H3 | W | 266 | G.H3.17 |
Polar | ICL2 | V | 942 | - | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | V | 942 | - | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | V | 942 | - | G.H5 | Y | 367 | G.H5.19 |
Polar | ICL2 | E | 946 | - | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | E | 946 | - | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM6 | G | 1039 | 6x41 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | G | 1039 | 6x41 | G.H5 | L | 373 | G.H5.25 |
Polar | C-term | Q | 1133 | - | G.h2s4 | E | 224 | G.h2s4.02 |
Van-der-waals | C-term | Q | 1133 | - | G.h2s4 | E | 224 | G.h2s4.02 |
Polar | C-term | Q | 1147 | - | G.H2 | K | 213 | G.H2.01 |
Hydrophobic | C-term | Q | 1147 | - | G.H2 | K | 213 | G.H2.01 |
Van-der-waals | C-term | Q | 1147 | - | G.H2 | K | 213 | G.H2.01 |
Hydrophobic | TM5 | L | 1023 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | L | 1023 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Aromatic | ICL2 | F | 943 | - | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | ICL2 | F | 943 | - | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | F | 943 | - | G.H5 | F | 356 | G.H5.08 |
Polar | TM6 | S | 1035 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | S | 1035 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM5 | L | 1023 | 5x68 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM5 | L | 1023 | 5x68 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | C-term | R | 1137 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | C-term | R | 1137 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | C-term | S | 1151 | - | G.s4h3 | E | 248 | G.s4h3.14 |
Hydrophobic | ICL2 | V | 942 | - | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | C-term | I | 1136 | - | G.H3 | P | 265 | G.H3.16 |
Van-der-waals | C-term | I | 1136 | - | G.H3 | P | 265 | G.H3.16 |
Hydrophobic | ICL2 | F | 943 | - | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | F | 943 | - | G.H5 | R | 360 | G.H5.12 |
Ionic | ICL2 | E | 946 | - | G.H5 | R | 366 | G.H5.18 |
Polar | ICL2 | E | 946 | - | G.H5 | R | 366 | G.H5.18 |
Van-der-waals | ICL2 | E | 946 | - | G.H5 | R | 366 | G.H5.18 |
Hydrophobic | C-term | I | 1136 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | C-term | W | 1140 | - | G.H3 | L | 257 | G.H3.08 |
Hydrophobic | C-term | S | 1265 | - | G.HN | I | 28 | G.HN.43 |
Hydrophobic | C-term | V | 1144 | - | G.H2 | R | 216 | G.H2.04 |
Van-der-waals | C-term | V | 1144 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | C-term | W | 1140 | - | G.H3 | L | 264 | G.H3.15 |
Hydrophobic | C-term | W | 1140 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | TM3 | L | 939 | 3x58 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | L | 939 | 3x58 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | ICL2 | F | 943 | - | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | C-term | K | 1261 | - | G.HN | I | 28 | G.HN.43 |
Van-der-waals | C-term | K | 1261 | - | G.HN | I | 28 | G.HN.43 |
Hydrophobic | TM5 | L | 1023 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM3 | L | 939 | 3x58 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | L | 939 | 3x58 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | C-term | I | 1264 | - | G.HN | I | 28 | G.HN.43 |
Polar | TM5 | L | 1023 | 5x68 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM5 | L | 1023 | 5x68 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM5 | L | 1023 | 5x68 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | C-term | W | 1140 | - | G.H3 | I | 261 | G.H3.12 |
Hydrophobic | C-term | V | 1144 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | V | 1144 | - | G.H2 | K | 217 | G.H2.05 |
Polar | H8 | Q | 1088 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | Q | 1088 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | Q | 1088 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Polar | TM2 | R | 879 | 2x46 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM2 | R | 879 | 2x46 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM2 | R | 879 | 2x46 | G.H5 | I | 371 | G.H5.23 |
Ionic | C-term | K | 1261 | - | G.HN | D | 25 | G.HN.40 |
Polar | C-term | K | 1261 | - | G.HN | D | 25 | G.HN.40 |
Hydrophobic | C-term | K | 1261 | - | G.HN | D | 25 | G.HN.40 |
Van-der-waals | C-term | K | 1261 | - | G.HN | D | 25 | G.HN.40 |
Hydrophobic | ICL2 | F | 943 | - | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | F | 943 | - | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | ICL2 | F | 943 | - | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | F | 943 | - | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | ICL2 | V | 942 | - | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | C-term | Q | 1147 | - | G.H3 | L | 257 | G.H3.08 |
Van-der-waals | C-term | Q | 1147 | - | G.H3 | L | 257 | G.H3.08 |
Polar | C-term | R | 1137 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | C-term | R | 1137 | - | G.H2 | H | 221 | G.H2.09 |
Van-der-waals | C-term | R | 1137 | - | G.H2 | H | 221 | G.H2.09 |
Polar | C-term | W | 1140 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | C-term | W | 1140 | - | G.H2 | R | 216 | G.H2.04 |
Van-der-waals | C-term | W | 1140 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | C-term | I | 1136 | - | G.H3 | L | 264 | G.H3.15 |
Polar | TM7 | L | 1087 | 7x60 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL2 | E | 946 | - | G.h2s4 | I | 227 | G.h2s4.05 |
Van-der-waals | ICL2 | E | 946 | - | G.h2s4 | I | 227 | G.h2s4.05 |