Gs - ADGRL3 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 65.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.8
PAE mean: 12.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 H 964 - G.HN Q 35 G.HN.52
Hydrophobic TM5 L 1040 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 L 1040 5x68 G.H5 R 385 G.H5.17
Hydrophobic ICL2 F 960 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 960 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 F 960 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 960 - G.S3 V 217 G.S3.01
Van-der-waals C-term F 1168 - G.H3 S 275 G.H3.11
Hydrophobic C-term I 1169 - G.H2 R 231 G.H2.04
Van-der-waals ICL3 K 1041 - G.H5 L 394 G.H5.26
Hydrophobic ICL2 V 959 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 V 959 - G.H5 H 387 G.H5.19
Polar H8 K 1106 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 1106 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 1106 8x48 G.H5 E 392 G.H5.24
Hydrophobic ICL2 F 960 - G.H5 R 380 G.H5.12
Polar H8 K 1107 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 K 1107 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 Q 1105 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 Q 1105 8x47 G.H5 E 392 G.H5.24
Hydrophobic C-term I 1209 - G.HN E 15 G.HN.32
Van-der-waals C-term I 1209 - G.HN E 15 G.HN.32
Ionic C-term R 1151 - G.h2s4 D 240 G.h2s4.03
Polar C-term R 1151 - G.h2s4 D 240 G.h2s4.03
Hydrophobic C-term R 1151 - G.h2s4 D 240 G.h2s4.03
Van-der-waals C-term R 1151 - G.h2s4 D 240 G.h2s4.03
Polar C-term K 1162 - G.h2s4 F 238 G.h2s4.01
Van-der-waals C-term K 1162 - G.h2s4 F 238 G.h2s4.01
Polar TM5 L 1040 5x68 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 L 1040 5x68 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 L 1040 5x68 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 E 963 - G.hns1 A 39 G.hns1.03
Hydrophobic TM5 M 1033 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 M 1033 5x61 G.H5 L 393 G.H5.25
Hydrophobic C-term T 1159 - G.H2 Q 236 G.H2.09
Hydrophobic TM5 H 1036 5x64 G.H5 L 394 G.H5.26
Aromatic ICL2 F 960 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 960 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 960 - G.H5 F 376 G.H5.08
Hydrophobic C-term I 1169 - G.H2 W 234 G.H2.07
Polar C-term Y 1207 - G.HN Q 19 G.HN.36
Hydrophobic C-term Y 1207 - G.HN Q 19 G.HN.36
Van-der-waals C-term Y 1207 - G.HN Q 19 G.HN.36
Hydrophobic ICL2 V 959 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 V 959 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 V 959 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 V 959 - G.H5 I 383 G.H5.15
Polar ICL2 S 962 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 S 962 - G.HN Q 35 G.HN.52
Hydrophobic C-term K 1162 - G.H2 I 235 G.H2.08
Van-der-waals C-term K 1162 - G.H2 I 235 G.H2.08
Hydrophobic TM5 L 1040 5x68 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 1040 5x68 G.H5 L 394 G.H5.26
Hydrophobic ICL2 S 962 - G.hns1 A 39 G.hns1.03
Polar TM5 H 1036 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 1036 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 1036 5x64 G.H5 R 385 G.H5.17
Polar ICL2 E 963 - G.S3 N 218 G.S3.02
Van-der-waals ICL2 E 963 - G.S3 N 218 G.S3.02
Polar TM5 K 1032 5x60 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 1032 5x60 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 1032 5x60 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 F 960 - G.H5 C 379 G.H5.11
Hydrophobic C-term K 1162 - G.H3 W 281 G.H3.17
Van-der-waals C-term K 1162 - G.H3 W 281 G.H3.17
Hydrophobic C-term I 1169 - G.H3 L 272 G.H3.08
Hydrophobic ICL2 E 963 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 E 963 - G.HN Q 35 G.HN.52
Hydrophobic TM5 H 1036 5x64 G.H5 L 388 G.H5.20
Van-der-waals TM5 H 1036 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM5 I 1039 5x67 G.H5 R 385 G.H5.17
Hydrophobic C-term F 1168 - G.H3 N 279 G.H3.15
Polar TM3 M 955 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 M 955 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 M 955 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 M 955 3x57 G.H5 Y 391 G.H5.23
Van-der-waals TM3 M 955 3x57 G.H5 Y 391 G.H5.23
Hydrophobic C-term M 1155 - G.h2s4 N 239 G.h2s4.02
Van-der-waals C-term M 1155 - G.h2s4 N 239 G.h2s4.02
Hydrophobic C-term Q 1163 - G.H2 I 235 G.H2.08
Aromatic ICL2 F 960 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 960 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 960 - G.S1 H 41 G.S1.02
Hydrophobic TM3 L 956 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 956 3x58 G.H5 L 388 G.H5.20
Hydrophobic TM5 M 1033 5x61 G.H5 L 394 G.H5.26
Polar TM3 L 956 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 956 3x58 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 E 961 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 E 961 - G.hns1 A 39 G.hns1.03
Ionic C-term E 1165 - G.H3 R 280 G.H3.16
Polar C-term E 1165 - G.H3 R 280 G.H3.16
Hydrophobic C-term E 1165 - G.H3 R 280 G.H3.16
Van-der-waals C-term E 1165 - G.H3 R 280 G.H3.16
Ionic TM5 H 1036 5x64 G.H5 D 381 G.H5.13
Polar TM5 H 1036 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 1036 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 1036 5x64 G.H5 D 381 G.H5.13
Polar ICL2 E 961 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 E 961 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 F 960 - G.S3 F 219 G.S3.03
Hydrophobic TM5 T 1037 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 T 1037 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM5 M 1033 5x61 G.H5 L 388 G.H5.20
Van-der-waals TM5 M 1033 5x61 G.H5 L 388 G.H5.20
Polar H8 K 1107 8x49 G.H5 Q 390 G.H5.22
Hydrophobic H8 K 1107 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 K 1107 8x49 G.H5 Q 390 G.H5.22
Hydrophobic TM6 L 1060 6x45 G.H5 L 393 G.H5.25
Polar TM5 H 1036 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 1036 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 1036 5x64 G.H5 Q 384 G.H5.16
Polar TM2 R 896 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 896 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 896 2x46 G.H5 Y 391 G.H5.23
Van-der-waals C-term E 1165 - G.H3 W 281 G.H3.17
Hydrophobic ICL2 V 959 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 V 959 - G.H5 Q 384 G.H5.16
Ionic ICL2 E 961 - G.hns1 R 38 G.hns1.02
Polar ICL2 E 961 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 E 961 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 E 961 - G.hns1 R 38 G.hns1.02
Hydrophobic C-term S 1166 - G.H2 I 235 G.H2.08