Beta-arrestin-2 - ADGRV1 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2024-10-31

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
ADGRV1 64.6
Beta-arrestin-2 75.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar C-term N 6276 - S9 C 151 N.S9.11
Hydrophobic C-term N 6276 - S9 C 151 N.S9.11
Van-der-waals C-term N 6276 - S9 C 151 N.S9.11
Hydrophobic C-term V 6273 - s20c C 409 C.s20c.19
Van-der-waals C-term V 6273 - s20c C 409 C.s20c.19
Hydrophobic C-term I 6299 - S6 K 78 N.S6.03
Van-der-waals C-term I 6299 - S6 K 78 N.S6.03
Hydrophobic ICL3 R 6097 - s15s16 F 245 C.s15s16.03
Hydrophobic C-term D 6275 - s1s2 S 14 N.s1s2.01
Van-der-waals C-term D 6275 - s1s2 S 14 N.s1s2.01
Ionic C-term E 6257 - s9s10 K 158 N.s9s10.09
Polar C-term E 6257 - s9s10 K 158 N.s9s10.09
Van-der-waals C-term E 6257 - s9s10 K 158 N.s9s10.09
Hydrophobic C-term A 6302 - s5s6 L 74 N.s5s6.10
Van-der-waals C-term A 6302 - s5s6 L 74 N.s5s6.10
Polar C-term E 6277 - S5 V 56 N.S5.04
Hydrophobic C-term E 6277 - S5 V 56 N.S5.04
Van-der-waals C-term E 6277 - S5 V 56 N.S5.04
Hydrophobic H8 M 6171 8x62 s7s8 N 123 N.s7s8.05
Hydrophobic C-term L 6296 - S6 K 78 N.S6.03
Van-der-waals C-term L 6296 - S6 K 78 N.S6.03
Hydrophobic C-term E 6277 - S9 A 149 N.S9.09
Van-der-waals C-term E 6277 - S9 A 149 N.S9.09
Hydrophobic C-term I 6299 - S6 F 76 N.S6.01
Van-der-waals C-term I 6299 - S6 F 76 N.S6.01
Hydrophobic C-term S 6274 - S2 V 21 N.S2.03
Van-der-waals C-term S 6274 - S2 V 21 N.S2.03
Hydrophobic C-term I 6299 - S6 R 77 N.S6.02
Van-der-waals C-term I 6299 - S6 R 77 N.S6.02
Hydrophobic C-term N 6276 - S5 V 54 N.S5.02
Van-der-waals C-term N 6276 - S5 V 54 N.S5.02
Hydrophobic ICL3 V 6095 - s15s16 S 246 C.s15s16.04
Van-der-waals ICL3 V 6095 - s15s16 S 246 C.s15s16.04
Hydrophobic C-term N 6276 - S2 L 19 N.S2.01
Van-der-waals C-term N 6276 - S2 L 19 N.S2.01
Hydrophobic H8 M 6171 8x62 s17s18 N 312 C.s17s18.37
Hydrophobic C-term D 6275 - S2 L 19 N.S2.01
Van-der-waals C-term D 6275 - S2 L 19 N.S2.01
Hydrophobic C-term S 6278 - S5 F 55 N.S5.03
Van-der-waals C-term S 6278 - S5 F 55 N.S5.03
Hydrophobic C-term S 6278 - S6 Q 86 N.S6.11
Van-der-waals C-term S 6278 - S6 Q 86 N.S6.11
Hydrophobic ICL3 V 6095 - S6 F 76 N.S6.01
Hydrophobic C-term S 6278 - S6 T 84 N.S6.09
Van-der-waals C-term S 6278 - S6 T 84 N.S6.09
Hydrophobic C-term P 6300 - S6 F 76 N.S6.01
Polar C-term D 6275 - S10 S 164 N.S10.01
Hydrophobic C-term D 6275 - S10 S 164 N.S10.01
Van-der-waals C-term D 6275 - S10 S 164 N.S10.01
Hydrophobic ICL2 E 6007 - s5s6 L 72 N.s5s6.08
Van-der-waals ICL2 E 6007 - s5s6 L 72 N.s5s6.08
Polar C-term N 6276 - S9 A 149 N.S9.09
Hydrophobic C-term N 6276 - S9 A 149 N.S9.09
Van-der-waals C-term N 6276 - S9 A 149 N.S9.09
Polar C-term D 6275 - S9 A 149 N.S9.09
Hydrophobic C-term D 6275 - S9 A 149 N.S9.09
Van-der-waals C-term D 6275 - S9 A 149 N.S9.09
Van-der-waals TM5 D 6094 5x68 s15s16 F 245 C.s15s16.03
Polar C-term S 6274 - s1s2 S 14 N.s1s2.01
Hydrophobic C-term S 6274 - s1s2 S 14 N.s1s2.01
Van-der-waals C-term S 6274 - s1s2 S 14 N.s1s2.01
Polar C-term D 6275 - s9s10 N 163 N.s9s10.14
Hydrophobic C-term D 6275 - s9s10 N 163 N.s9s10.14
Van-der-waals C-term D 6275 - s9s10 N 163 N.s9s10.14
Hydrophobic C-term D 6275 - S10 V 165 N.S10.02
Van-der-waals C-term D 6275 - S10 V 165 N.S10.02
Polar C-term S 6274 - S2 T 20 N.S2.02
Hydrophobic C-term S 6274 - S2 T 20 N.S2.02
Van-der-waals C-term S 6274 - S2 T 20 N.S2.02
Hydrophobic C-term E 6277 - s9s10 L 155 N.s9s10.03
Ionic ICL2 E 6004 - s8s9 K 139 N.s8s9.09
Polar ICL2 E 6004 - s8s9 K 139 N.s8s9.09
Hydrophobic ICL2 E 6004 - s8s9 K 139 N.s8s9.09
Van-der-waals ICL2 E 6004 - s8s9 K 139 N.s8s9.09
Polar C-term S 6272 - s1s2 S 14 N.s1s2.01
Hydrophobic C-term S 6272 - s1s2 S 14 N.s1s2.01
Van-der-waals C-term S 6272 - s1s2 S 14 N.s1s2.01
Hydrophobic C-term L 6296 - s17s18 E 314 C.s17s18.39
Van-der-waals C-term L 6296 - s17s18 E 314 C.s17s18.39
Ionic C-term E 6277 - S9 R 148 N.S9.08
Polar C-term E 6277 - S9 R 148 N.S9.08
Hydrophobic C-term E 6277 - S9 R 148 N.S9.08
Van-der-waals C-term E 6277 - S9 R 148 N.S9.08
Hydrophobic ICL2 R 6008 - s5s6 L 72 N.s5s6.08
Van-der-waals ICL2 R 6008 - s5s6 L 72 N.s5s6.08
Polar C-term E 6277 - S5 T 57 N.S5.05
Hydrophobic C-term E 6277 - S5 T 57 N.S5.05
Van-der-waals C-term E 6277 - S5 T 57 N.S5.05
Hydrophobic C-term D 6275 - S9 F 150 N.S9.10
Polar C-term N 6276 - S5 F 55 N.S5.03
Hydrophobic C-term N 6276 - S5 F 55 N.S5.03
Van-der-waals C-term N 6276 - S5 F 55 N.S5.03
Hydrophobic C-term N 6276 - S9 F 150 N.S9.10
Polar C-term N 6276 - S9 F 150 N.S9.10
Van-der-waals C-term N 6276 - S9 F 150 N.S9.10
Polar C-term S 6274 - S2 L 19 N.S2.01
Hydrophobic C-term S 6274 - S2 L 19 N.S2.01
Van-der-waals C-term S 6274 - S2 L 19 N.S2.01
Polar C-term V 6273 - S1 S 13 N.S1.05
Hydrophobic C-term V 6273 - S1 S 13 N.S1.05
Van-der-waals C-term V 6273 - S1 S 13 N.S1.05
Hydrophobic C-term Q 6280 - s9s10 L 155 N.s9s10.03
Van-der-waals C-term Q 6280 - s9s10 L 155 N.s9s10.03
Ionic C-term D 6260 - s9s10 R 162 N.s9s10.13
Polar C-term D 6260 - s9s10 R 162 N.s9s10.13
Hydrophobic C-term D 6260 - s9s10 R 162 N.s9s10.13
Van-der-waals C-term D 6260 - s9s10 R 162 N.s9s10.13
Hydrophobic C-term R 6297 - s15s16 F 245 C.s15s16.03
Van-der-waals C-term R 6297 - s15s16 F 245 C.s15s16.03
Hydrophobic C-term I 6301 - S6 F 76 N.S6.01
Van-der-waals C-term I 6301 - S6 F 76 N.S6.01
Hydrophobic C-term E 6277 - S9 F 150 N.S9.10
Van-der-waals C-term E 6277 - S9 F 150 N.S9.10
Hydrophobic C-term M 6206 - s8s9 E 135 N.s8s9.05
Van-der-waals C-term M 6206 - s8s9 E 135 N.s8s9.05
Hydrophobic C-term S 6272 - s20c C 409 C.s20c.19
Van-der-waals C-term S 6272 - s20c C 409 C.s20c.19
Polar H8 V 6169 8x60 s17s18 N 312 C.s17s18.37
Hydrophobic H8 V 6169 8x60 s17s18 N 312 C.s17s18.37
Van-der-waals H8 V 6169 8x60 s17s18 N 312 C.s17s18.37
Hydrophobic C-term S 6274 - S10 V 165 N.S10.02
Van-der-waals C-term S 6274 - S10 V 165 N.S10.02
Aromatic C-term F 6263 - s9s10 R 162 N.s9s10.13
Polar C-term S 6272 - S1 S 13 N.S1.05
Hydrophobic C-term S 6272 - S1 S 13 N.S1.05
Van-der-waals C-term S 6272 - S1 S 13 N.S1.05
Hydrophobic C-term I 6299 - s15s16 F 245 C.s15s16.03
Van-der-waals C-term I 6299 - s15s16 F 245 C.s15s16.03
Hydrophobic C-term V 6273 - S10 R 166 N.S10.03
Van-der-waals C-term V 6273 - S10 R 166 N.S10.03
Hydrophobic C-term R 6298 - s15s16 F 245 C.s15s16.03
Polar C-term S 6274 - S1 S 13 N.S1.05
Hydrophobic C-term S 6274 - S1 S 13 N.S1.05
Van-der-waals C-term S 6274 - S1 S 13 N.S1.05
Hydrophobic C-term G 6279 - S6 Y 85 N.S6.10
Van-der-waals C-term G 6279 - S6 Y 85 N.S6.10
Hydrophobic C-term S 6278 - s9s10 L 155 N.s9s10.03
Van-der-waals C-term S 6278 - s9s10 L 155 N.s9s10.03
Hydrophobic C-term S 6274 - S1 K 12 N.S1.04
Van-der-waals C-term S 6274 - S1 K 12 N.S1.04
Polar C-term S 6278 - S6 Y 85 N.S6.10
Hydrophobic C-term S 6278 - S6 Y 85 N.S6.10
Van-der-waals C-term S 6278 - S6 Y 85 N.S6.10
Hydrophobic C-term P 6300 - s5s6 L 74 N.s5s6.10
Van-der-waals C-term P 6300 - s5s6 L 74 N.s5s6.10
Polar ICL3 V 6095 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL3 V 6095 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 V 6095 - s15s16 F 245 C.s15s16.03
Polar ICL2 R 6008 - s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 R 6008 - s5s6 V 71 N.s5s6.07
Van-der-waals ICL2 R 6008 - s5s6 V 71 N.s5s6.07
Hydrophobic C-term L 6271 - s1s2 P 15 N.s1s2.02
Polar ICL2 H 6005 - s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 H 6005 - s5s6 L 72 N.s5s6.08
Van-der-waals ICL2 H 6005 - s5s6 L 72 N.s5s6.08
Hydrophobic C-term L 6271 - s9s10 K 161 N.s9s10.12
Polar C-term V 6273 - S1 K 12 N.S1.04
Hydrophobic C-term V 6273 - S1 K 12 N.S1.04
Van-der-waals C-term V 6273 - S1 K 12 N.S1.04
Hydrophobic C-term G 6279 - S6 T 84 N.S6.09
Van-der-waals C-term G 6279 - S6 T 84 N.S6.09
Van-der-waals H8 V 6169 8x60 s17s18 E 314 C.s17s18.39
Polar C-term L 6271 - s20c Q 407 C.s20c.17
Polar C-term L 6271 - s20c C 409 C.s20c.19
Hydrophobic C-term L 6271 - s20c C 409 C.s20c.19
Van-der-waals C-term L 6271 - s20c C 409 C.s20c.19
Ionic ICL3 R 6097 - s17s18 E 314 C.s17s18.39
Polar ICL3 R 6097 - s17s18 E 314 C.s17s18.39
Hydrophobic ICL3 R 6097 - s17s18 E 314 C.s17s18.39
Van-der-waals ICL3 R 6097 - s17s18 E 314 C.s17s18.39
Hydrophobic C-term G 6279 - s9s10 L 155 N.s9s10.03
Hydrophobic C-term I 6301 - s5s6 L 74 N.s5s6.10
Hydrophobic C-term N 6276 - S5 V 56 N.S5.04
Polar C-term E 6277 - S5 F 55 N.S5.03
Hydrophobic C-term E 6277 - S5 F 55 N.S5.03
Van-der-waals C-term E 6277 - S5 F 55 N.S5.03
Hydrophobic C-term V 6273 - S10 V 165 N.S10.02
Van-der-waals C-term V 6273 - S10 V 165 N.S10.02
Hydrophobic TM5 Q 6088 5x62 s8s9 T 137 N.s8s9.07
Hydrophobic TM5 Y 6092 5x66 s8s9 K 139 N.s8s9.09
Van-der-waals TM5 Y 6092 5x66 s8s9 K 139 N.s8s9.09
Hydrophobic ICL2 H 6005 - s5s6 L 69 N.s5s6.05
Van-der-waals ICL2 H 6005 - s5s6 L 69 N.s5s6.05
Polar C-term S 6272 - s1s2 P 15 N.s1s2.02
Hydrophobic C-term S 6272 - s1s2 P 15 N.s1s2.02
Van-der-waals C-term S 6272 - s1s2 P 15 N.s1s2.02