Gq - AT2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 11.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term M 358 - G.H2 I 217 G.H2.08
Hydrophobic TM3 R 142 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 142 3x50 G.H5 L 358 G.H5.25
Hydrophobic ICL2 F 150 34x51 G.S3 V 199 G.S3.01
Van-der-waals ICL2 F 150 34x51 G.S3 V 199 G.S3.01
Polar TM4 N 156 4x38 G.hns1 R 37 G.hns1.02
Van-der-waals TM4 N 156 4x38 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 P 149 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 149 34x50 G.H5 I 348 G.H5.15
Polar ICL2 R 154 34x55 G.s2s3 S 198 G.s2s3.02
Hydrophobic ICL2 R 154 34x55 G.s2s3 S 198 G.s2s3.02
Van-der-waals ICL2 R 154 34x55 G.s2s3 S 198 G.s2s3.02
Polar TM6 N 247 6x26 G.H5 D 346 G.H5.13
Van-der-waals TM6 N 247 6x26 G.H5 D 346 G.H5.13
Polar C-term V 362 - G.H2 R 214 G.H2.05
Hydrophobic C-term V 362 - G.H2 R 214 G.H2.05
Van-der-waals C-term V 362 - G.H2 R 214 G.H2.05
Polar TM6 V 254 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 V 254 6x33 G.H5 L 358 G.H5.25
Polar TM7 C 319 7x54 G.H5 N 357 G.H5.24
Polar TM7 Y 318 7x53 G.H5 N 357 G.H5.24
Hydrophobic TM7 Y 318 7x53 G.H5 N 357 G.H5.24
Van-der-waals TM7 Y 318 7x53 G.H5 N 357 G.H5.24
Hydrophobic ICL2 P 149 34x50 G.H5 L 349 G.H5.16
Polar TM3 R 142 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 142 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 142 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM2 S 79 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 S 79 2x39 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 Q 153 34x54 G.H5 I 348 G.H5.15
Van-der-waals ICL2 Q 153 34x54 G.H5 I 348 G.H5.15
Polar ICL2 R 154 34x55 G.hns1 R 37 G.hns1.02
Hydrophobic TM3 V 146 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM6 T 250 6x29 G.H5 Q 350 G.H5.17
Ionic TM6 K 246 6x25 G.h4s6 D 321 G.h4s6.12
Polar TM6 K 246 6x25 G.h4s6 D 321 G.h4s6.12
Hydrophobic TM6 K 246 6x25 G.h4s6 D 321 G.h4s6.12
Van-der-waals TM6 K 246 6x25 G.h4s6 D 321 G.h4s6.12
Polar ICL2 R 155 34x56 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 R 155 34x56 G.H5 Y 356 G.H5.23
Polar TM3 D 141 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 141 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 141 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 V 146 3x54 G.H5 L 349 G.H5.16
Aromatic C-term F 361 - G.H3 Y 261 G.H3.15
Hydrophobic C-term F 361 - G.H3 Y 261 G.H3.15
Van-der-waals C-term F 361 - G.H3 Y 261 G.H3.15
Polar ICL2 S 152 34x53 G.H5 N 352 G.H5.19
Hydrophobic ICL2 S 152 34x53 G.H5 N 352 G.H5.19
Van-der-waals ICL2 S 152 34x53 G.H5 N 352 G.H5.19
Hydrophobic TM6 Q 253 6x32 G.H5 V 359 G.H5.26
Van-der-waals TM6 Q 253 6x32 G.H5 V 359 G.H5.26
Hydrophobic C-term F 361 - G.H3 T 257 G.H3.11
Van-der-waals C-term F 361 - G.H3 T 257 G.H3.11
Hydrophobic TM6 T 250 6x29 G.H5 L 353 G.H5.20
Hydrophobic TM3 S 145 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 S 145 3x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 F 150 34x51 G.S3 F 201 G.S3.03
Hydrophobic TM6 V 254 6x33 G.H5 V 359 G.H5.26
Van-der-waals TM6 V 254 6x33 G.H5 V 359 G.H5.26
Hydrophobic TM5 L 238 5x65 G.H5 L 349 G.H5.16
Polar TM2 S 79 2x39 G.H5 E 355 G.H5.22
Hydrophobic TM2 S 79 2x39 G.H5 E 355 G.H5.22
Hydrophobic ICL2 F 150 34x51 G.S1 L 40 G.S1.02
Van-der-waals ICL2 F 150 34x51 G.S1 L 40 G.S1.02
Aromatic ICL2 F 150 34x51 G.H5 F 341 G.H5.08
Hydrophobic ICL2 F 150 34x51 G.H5 F 341 G.H5.08
Van-der-waals ICL2 F 150 34x51 G.H5 F 341 G.H5.08
Hydrophobic H8 G 322 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 G 322 8x47 G.H5 N 357 G.H5.24
Polar TM6 K 246 6x25 G.h4s6 S 320 G.h4s6.11
Hydrophobic TM6 K 246 6x25 G.h4s6 S 320 G.h4s6.11
Van-der-waals TM6 K 246 6x25 G.h4s6 S 320 G.h4s6.11
Hydrophobic TM6 N 247 6x26 G.h4s6 I 323 G.h4s6.20
Van-der-waals TM6 N 247 6x26 G.h4s6 I 323 G.h4s6.20
Ionic ICL1 K 77 - G.H5 E 355 G.H5.22
Polar ICL1 K 77 - G.H5 E 355 G.H5.22
Hydrophobic ICL1 K 77 - G.H5 E 355 G.H5.22
Van-der-waals ICL1 K 77 - G.H5 E 355 G.H5.22
Hydrophobic TM6 V 254 6x33 G.H5 L 353 G.H5.20
Van-der-waals TM6 V 254 6x33 G.H5 L 353 G.H5.20
Hydrophobic ICL2 F 150 34x51 G.H5 V 344 G.H5.11
Hydrophobic TM6 T 250 6x29 G.H5 V 359 G.H5.26
Van-der-waals TM6 T 250 6x29 G.H5 V 359 G.H5.26
Hydrophobic TM4 P 157 4x39 G.hns1 R 37 G.hns1.02
Van-der-waals TM4 P 157 4x39 G.hns1 R 37 G.hns1.02
Polar H8 N 323 8x48 G.H5 V 359 G.H5.26
Hydrophobic ICL2 F 150 34x51 G.H5 K 345 G.H5.12
Van-der-waals ICL2 F 150 34x51 G.H5 K 345 G.H5.12
Polar ICL2 R 154 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 R 154 34x55 G.hns1 R 38 G.hns1.03
Polar TM3 S 145 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 S 145 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 S 145 3x53 G.H5 N 352 G.H5.19
Hydrophobic ICL2 Q 153 34x54 G.S1 L 40 G.S1.02
Van-der-waals ICL2 Q 153 34x54 G.S1 L 40 G.S1.02
Hydrophobic TM6 M 257 6x36 G.H5 L 358 G.H5.25
Hydrophobic ICL2 P 149 34x50 G.H5 K 345 G.H5.12
Van-der-waals ICL2 P 149 34x50 G.H5 K 345 G.H5.12
Hydrophobic ICL2 F 150 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 F 150 34x51 G.H5 I 348 G.H5.15