Golf -
apelin receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM6 | E | 238 | 6x25 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | TM6 | E | 238 | 6x25 | G.h4s6 | Y | 345 | G.h4s6.20 |
Van-der-waals | TM6 | E | 238 | 6x25 | G.h4s6 | Y | 345 | G.h4s6.20 |
Polar | ICL3 | K | 234 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Hydrophobic | ICL3 | K | 234 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Van-der-waals | ICL3 | K | 234 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Hydrophobic | TM3 | A | 130 | 3x53 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | A | 130 | 3x53 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM4 | R | 143 | 4x39 | G.HN | L | 37 | G.HN.52 |
Van-der-waals | TM4 | R | 143 | 4x39 | G.HN | L | 37 | G.HN.52 |
Ionic | TM5 | H | 231 | 5x68 | G.H5 | D | 365 | G.H5.10 |
Polar | TM6 | K | 242 | 6x29 | G.h4s6 | G | 342 | G.h4s6.11 |
Hydrophobic | TM6 | K | 242 | 6x29 | G.h4s6 | G | 342 | G.h4s6.11 |
Van-der-waals | TM6 | K | 242 | 6x29 | G.h4s6 | G | 342 | G.h4s6.11 |
Hydrophobic | TM3 | A | 130 | 3x53 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL2 | V | 135 | 34x51 | G.s2s3 | D | 202 | G.s2s3.01 |
Van-der-waals | ICL2 | V | 135 | 34x51 | G.s2s3 | D | 202 | G.s2s3.01 |
Hydrophobic | ICL2 | R | 139 | 34x55 | G.s2s3 | K | 203 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 139 | 34x55 | G.s2s3 | K | 203 | G.s2s3.02 |
Ionic | H8 | R | 315 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Polar | H8 | R | 315 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | R | 315 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | R | 315 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM6 | K | 242 | 6x29 | G.h4s6 | K | 343 | G.h4s6.12 |
Van-der-waals | TM6 | K | 242 | 6x29 | G.h4s6 | K | 343 | G.h4s6.12 |
Polar | TM6 | K | 242 | 6x29 | G.h4s6 | D | 341 | G.h4s6.10 |
Hydrophobic | TM6 | K | 242 | 6x29 | G.h4s6 | D | 341 | G.h4s6.10 |
Van-der-waals | TM6 | K | 242 | 6x29 | G.h4s6 | D | 341 | G.h4s6.10 |
Hydrophobic | TM3 | I | 131 | 3x54 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM3 | I | 131 | 3x54 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM6 | L | 246 | 6x33 | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | TM6 | L | 246 | 6x33 | G.H5 | K | 376 | G.H5.21 |
Hydrophobic | TM3 | R | 127 | 3x50 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM3 | R | 127 | 3x50 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL2 | A | 138 | 34x54 | G.S3 | V | 204 | G.S3.01 |
Van-der-waals | ICL2 | A | 138 | 34x54 | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | TM3 | D | 126 | 3x49 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM3 | D | 126 | 3x49 | G.H5 | L | 380 | G.H5.25 |
Ionic | TM2 | R | 62 | 2x37 | G.H5 | E | 379 | G.H5.24 |
Polar | TM2 | R | 62 | 2x37 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM2 | R | 62 | 2x37 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM2 | R | 62 | 2x37 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL2 | V | 135 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Van-der-waals | ICL2 | V | 135 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | ICL2 | P | 134 | 34x50 | G.H5 | L | 375 | G.H5.20 |
Polar | ICL1 | R | 61 | 12x52 | G.hns1 | K | 40 | G.hns1.02 |
Polar | ICL2 | V | 135 | 34x51 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | ICL2 | V | 135 | 34x51 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | ICL2 | V | 135 | 34x51 | G.H5 | Q | 371 | G.H5.16 |
Polar | TM3 | R | 127 | 3x50 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM3 | R | 127 | 3x50 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM3 | R | 127 | 3x50 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM4 | L | 142 | 4x38 | G.hns1 | A | 41 | G.hns1.03 |
Hydrophobic | ICL2 | V | 135 | 34x51 | G.H5 | R | 367 | G.H5.12 |
Van-der-waals | ICL2 | V | 135 | 34x51 | G.H5 | R | 367 | G.H5.12 |
Polar | TM6 | G | 239 | 6x26 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | TM6 | G | 239 | 6x26 | G.h4s6 | Y | 345 | G.h4s6.20 |
Van-der-waals | TM6 | G | 239 | 6x26 | G.h4s6 | Y | 345 | G.h4s6.20 |
Polar | ICL2 | P | 134 | 34x50 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | ICL2 | P | 134 | 34x50 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | ICL2 | P | 134 | 34x50 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM4 | V | 144 | 4x40 | G.HN | L | 37 | G.HN.52 |
Van-der-waals | TM4 | V | 144 | 4x40 | G.HN | L | 37 | G.HN.52 |
Hydrophobic | TM6 | L | 246 | 6x33 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | L | 246 | 6x33 | G.H5 | L | 381 | G.H5.26 |
Polar | H8 | R | 315 | 8x49 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | ICL3 | E | 235 | - | G.S6 | Y | 347 | G.S6.02 |
Van-der-waals | ICL3 | E | 235 | - | G.S6 | Y | 347 | G.S6.02 |
Ionic | ICL1 | E | 59 | 12x50 | G.HN | R | 36 | G.HN.51 |
Hydrophobic | ICL1 | E | 59 | 12x50 | G.HN | R | 36 | G.HN.51 |
Van-der-waals | ICL1 | E | 59 | 12x50 | G.HN | R | 36 | G.HN.51 |
Hydrophobic | TM4 | R | 143 | 4x39 | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | TM4 | R | 143 | 4x39 | G.hns1 | K | 40 | G.hns1.02 |
Polar | ICL1 | R | 58 | 12x49 | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | ICL2 | R | 141 | 34x57 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | ICL2 | R | 141 | 34x57 | G.H5 | L | 375 | G.H5.20 |
Polar | TM3 | I | 131 | 3x54 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM3 | I | 131 | 3x54 | G.H5 | R | 372 | G.H5.17 |
Polar | TM5 | H | 231 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Aromatic | TM5 | H | 231 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM5 | H | 231 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM5 | H | 231 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM6 | R | 243 | 6x30 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM6 | R | 243 | 6x30 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM2 | A | 64 | 2x39 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM2 | A | 64 | 2x39 | G.H5 | L | 380 | G.H5.25 |
Polar | TM6 | K | 242 | 6x29 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | TM6 | K | 242 | 6x29 | G.h4s6 | Y | 345 | G.h4s6.20 |
Van-der-waals | TM6 | K | 242 | 6x29 | G.h4s6 | Y | 345 | G.h4s6.20 |
Polar | ICL2 | R | 139 | 34x55 | G.S2 | Q | 200 | G.S2.07 |
Hydrophobic | TM2 | R | 62 | 2x37 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM2 | R | 62 | 2x37 | G.H5 | Y | 378 | G.H5.23 |
Polar | TM5 | T | 227 | 5x64 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM5 | T | 227 | 5x64 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM5 | T | 227 | 5x64 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM4 | L | 142 | 4x38 | G.HN | L | 37 | G.HN.52 |
Hydrophobic | TM2 | S | 63 | 2x38 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM2 | S | 63 | 2x38 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | P | 134 | 34x50 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | ICL2 | P | 134 | 34x50 | G.H5 | D | 368 | G.H5.13 |
Ionic | TM5 | H | 231 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM5 | H | 231 | 5x68 | G.H5 | I | 369 | G.H5.14 |
Van-der-waals | TM5 | H | 231 | 5x68 | G.H5 | I | 369 | G.H5.14 |
Polar | ICL1 | E | 59 | 12x50 | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | ICL1 | E | 59 | 12x50 | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | C-term | L | 377 | - | G.h1ha | V | 67 | G.h1ha.01 |
Polar | ICL1 | R | 58 | 12x49 | G.HN | R | 36 | G.HN.51 |
Hydrophobic | ICL1 | R | 58 | 12x49 | G.HN | R | 36 | G.HN.51 |
Van-der-waals | ICL1 | R | 58 | 12x49 | G.HN | R | 36 | G.HN.51 |