Ggust - apelin receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 13.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 R 141 34x57 G.H5 C 351 G.H5.23
Van-der-waals C-term Y 372 - G.H1 K 51 G.H1.06
Ionic C-term E 367 - G.hfs2 K 180 G.hfs2.04
Polar C-term E 367 - G.hfs2 K 180 G.hfs2.04
Hydrophobic C-term E 367 - G.hfs2 K 180 G.hfs2.04
Van-der-waals C-term E 367 - G.hfs2 K 180 G.hfs2.04
Hydrophobic ICL2 V 135 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 135 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM6 L 246 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 246 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 246 6x33 G.H5 L 353 G.H5.25
Ionic ICL2 R 139 34x55 G.HN E 28 G.HN.52
Polar ICL2 R 139 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL2 R 139 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 R 139 34x55 G.HN E 28 G.HN.52
Hydrophobic C-term L 377 - G.S2 F 189 G.S2.06
Van-der-waals C-term L 377 - G.S2 F 189 G.S2.06
Hydrophobic TM3 I 131 3x54 G.H5 L 353 G.H5.25
Ionic ICL2 R 141 34x57 G.H5 D 350 G.H5.22
Polar ICL2 R 141 34x57 G.H5 D 350 G.H5.22
Hydrophobic ICL2 R 141 34x57 G.H5 D 350 G.H5.22
Van-der-waals ICL2 R 141 34x57 G.H5 D 350 G.H5.22
Hydrophobic C-term I 370 - H.HA F 69 H.HA.07
Hydrophobic TM5 H 231 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 231 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM3 R 127 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 127 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 131 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 131 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 V 135 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL3 E 235 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 E 235 - G.h4s6 E 318 G.h4s6.12
Polar C-term L 377 - G.S2 Q 188 G.S2.05
Hydrophobic C-term L 377 - G.S2 Q 188 G.S2.05
Van-der-waals C-term L 377 - G.S2 Q 188 G.S2.05
Hydrophobic TM3 I 131 3x54 G.H5 I 344 G.H5.16
Polar TM3 A 130 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 130 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 130 3x53 G.H5 N 347 G.H5.19
Hydrophobic C-term Y 372 - G.S2 I 185 G.S2.02
Van-der-waals C-term Y 372 - G.S2 I 185 G.S2.02
Hydrophobic TM4 L 142 4x38 G.HN A 27 G.HN.51
Van-der-waals TM4 L 142 4x38 G.HN A 27 G.HN.51
Polar TM6 R 236 6x23 G.H4 N 305 G.H4.13
Hydrophobic TM5 H 231 5x68 G.H5 K 345 G.H5.17
Hydrophobic TM6 L 246 6x33 G.H5 L 348 G.H5.20
Ionic C-term E 375 - G.H1 K 54 G.H1.09
Polar C-term E 375 - G.H1 K 54 G.H1.09
Van-der-waals C-term E 375 - G.H1 K 54 G.H1.09
Hydrophobic TM3 A 130 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 130 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM4 L 142 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 L 142 4x38 G.HN E 28 G.HN.52
Hydrophobic C-term L 377 - G.h1ha K 58 G.h1ha.01
Van-der-waals C-term L 377 - G.h1ha K 58 G.h1ha.01
Hydrophobic TM5 F 232 5x69 G.H5 L 348 G.H5.20
Hydrophobic H8 P 314 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 P 314 8x48 G.H5 F 354 G.H5.26
Ionic TM5 H 231 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 231 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 231 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 231 5x68 G.H5 D 341 G.H5.13
Hydrophobic C-term M 365 - H.HA Q 79 H.HA.17
Van-der-waals C-term M 365 - H.HA Q 79 H.HA.17
Hydrophobic TM5 T 227 5x64 G.H5 I 344 G.H5.16
Hydrophobic ICL2 V 135 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 V 135 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM6 I 249 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 249 6x36 G.H5 L 353 G.H5.25
Van-der-waals ICL2 P 134 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM2 A 64 2x39 G.H5 C 351 G.H5.23
Polar TM4 L 142 4x38 G.HN Q 24 G.HN.48
Hydrophobic TM4 L 142 4x38 G.HN Q 24 G.HN.48
Van-der-waals TM4 L 142 4x38 G.HN Q 24 G.HN.48
Polar TM3 D 126 3x49 G.H5 C 351 G.H5.23
Hydrophobic C-term I 370 - H.HA V 72 H.HA.10
Van-der-waals C-term I 370 - H.HA V 72 H.HA.10
Hydrophobic TM5 I 228 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM4 L 142 4x38 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 V 135 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 V 135 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 P 134 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 134 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM2 R 62 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 62 2x37 G.H5 D 350 G.H5.22
Ionic C-term K 368 - H.hbhc D 116 H.hbhc.04
Polar C-term K 368 - H.hbhc D 116 H.hbhc.04
Hydrophobic C-term K 368 - H.hbhc D 116 H.hbhc.04
Van-der-waals C-term K 368 - H.hbhc D 116 H.hbhc.04
Polar TM2 R 62 2x37 G.H5 K 349 G.H5.21
Hydrophobic C-term T 376 - G.S2 Q 188 G.S2.05
Van-der-waals C-term T 376 - G.S2 Q 188 G.S2.05
Ionic ICL3 K 234 - G.H5 D 337 G.H5.09
Polar ICL3 K 234 - G.H5 D 337 G.H5.09
Hydrophobic TM2 R 62 2x37 G.H5 G 352 G.H5.24
Van-der-waals TM2 R 62 2x37 G.H5 G 352 G.H5.24
Hydrophobic H8 D 313 8x47 G.H5 G 352 G.H5.24
Polar TM6 K 242 6x29 G.h4s6 E 315 G.h4s6.09
Van-der-waals TM6 K 242 6x29 G.h4s6 E 315 G.h4s6.09
Ionic TM4 R 143 4x39 G.HN E 28 G.HN.52
Polar TM4 R 143 4x39 G.HN E 28 G.HN.52
Hydrophobic TM6 R 236 6x23 G.H4 L 308 G.H4.16
Polar TM3 R 127 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 127 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 127 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 134 34x50 G.H5 I 344 G.H5.16
Polar ICL2 R 141 34x57 G.H5 N 347 G.H5.19
Hydrophobic C-term I 370 - G.hfs2 V 179 G.hfs2.03
Van-der-waals C-term I 370 - G.hfs2 V 179 G.hfs2.03
Hydrophobic TM5 F 232 5x69 G.H5 K 345 G.H5.17
Van-der-waals TM5 F 232 5x69 G.H5 K 345 G.H5.17
Polar C-term E 375 - G.h1ha K 58 G.h1ha.01
Van-der-waals C-term E 375 - G.h1ha K 58 G.h1ha.01
Hydrophobic ICL2 P 134 34x50 G.H5 T 340 G.H5.12
Aromatic TM6 R 245 6x32 G.H5 F 354 G.H5.26
Ionic ICL3 E 235 - G.H5 K 345 G.H5.17
Polar ICL3 E 235 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 E 235 - G.H5 K 345 G.H5.17
Hydrophobic TM6 K 242 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 R 139 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 139 34x55 G.hns1 R 32 G.hns1.03