G15 - CCR3 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 135 3x54 G.H5 L 373 G.H5.25
Van-der-waals TM3 I 135 3x54 G.H5 L 373 G.H5.25
Hydrophobic ICL2 L 142 34x54 G.h2s4 I 227 G.h2s4.05
Hydrophobic ICL2 R 145 34x57 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 R 145 34x57 G.H5 Y 367 G.H5.19
Hydrophobic TM6 A 237 6x33 G.H5 L 368 G.H5.20
Polar TM3 R 131 3x50 G.H5 I 371 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 I 371 G.H5.23
Hydrophobic ICL2 V 139 34x51 G.S1 L 43 G.S1.02
Hydrophobic TM6 A 237 6x33 G.H5 L 374 G.H5.26
Hydrophobic TM6 I 244 6x40 G.H5 L 373 G.H5.25
Hydrophobic ICL2 V 139 34x51 G.S3 T 202 G.S3.01
Van-der-waals ICL2 V 139 34x51 G.S3 T 202 G.S3.01
Polar ICL2 A 141 34x53 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 A 141 34x53 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 A 141 34x53 G.H5 Y 367 G.H5.19
Hydrophobic TM3 I 135 3x54 G.H5 L 364 G.H5.16
Van-der-waals TM3 I 135 3x54 G.H5 L 364 G.H5.16
Hydrophobic TM4 T 146 4x38 G.hns1 R 40 G.hns1.02
Van-der-waals TM4 T 146 4x38 G.hns1 R 40 G.hns1.02
Hydrophobic TM6 K 236 6x32 G.H5 L 374 G.H5.26
Van-der-waals TM6 K 236 6x32 G.H5 L 374 G.H5.26
Van-der-waals H8 G 305 8x47 G.H5 L 374 G.H5.26
Hydrophobic ICL2 A 138 34x50 G.H5 V 363 G.H5.15
Polar ICL2 L 142 34x54 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 L 142 34x54 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 L 142 34x54 G.H5 Y 367 G.H5.19
Polar TM7 Y 301 7x53 G.H5 N 372 G.H5.24
Van-der-waals TM7 Y 301 7x53 G.H5 N 372 G.H5.24
Hydrophobic TM3 I 135 3x54 G.H5 I 371 G.H5.23
Van-der-waals TM3 I 135 3x54 G.H5 I 371 G.H5.23
Hydrophobic ICL2 L 142 34x54 G.S1 L 43 G.S1.02
Van-der-waals ICL2 L 142 34x54 G.S1 L 43 G.S1.02
Polar H8 E 306 8x48 G.H5 L 374 G.H5.26
Hydrophobic H8 E 306 8x48 G.H5 L 374 G.H5.26
Van-der-waals H8 E 306 8x48 G.H5 L 374 G.H5.26
Hydrophobic TM3 I 135 3x54 G.H5 L 368 G.H5.20
Hydrophobic ICL2 L 142 34x54 G.H5 V 363 G.H5.15
Hydrophobic ICL2 L 142 34x54 G.H5 R 366 G.H5.18
Van-der-waals ICL2 L 142 34x54 G.H5 R 366 G.H5.18
Hydrophobic TM5 C 229 5x68 G.H5 L 364 G.H5.16
Van-der-waals TM5 C 229 5x68 G.H5 L 364 G.H5.16
Hydrophobic TM3 A 134 3x53 G.H5 I 371 G.H5.23
Van-der-waals TM6 K 233 6x29 G.h4s6 R 335 G.h4s6.17
Hydrophobic ICL3 P 230 - G.H5 D 361 G.H5.13
Van-der-waals ICL3 P 230 - G.H5 D 361 G.H5.13
Hydrophobic TM6 A 237 6x33 G.H5 L 373 G.H5.25
Hydrophobic H8 G 305 8x47 G.H5 N 372 G.H5.24
Polar ICL3 S 231 - G.h4s6 R 338 G.h4s6.20
Hydrophobic ICL3 S 231 - G.h4s6 R 338 G.h4s6.20
Van-der-waals ICL3 S 231 - G.h4s6 R 338 G.h4s6.20
Hydrophobic TM2 T 69 2x39 G.H5 I 371 G.H5.23
Hydrophobic ICL2 R 143 34x55 G.hns1 R 40 G.hns1.02
Van-der-waals ICL2 R 143 34x55 G.hns1 R 40 G.hns1.02
Hydrophobic TM6 K 233 6x29 G.H5 L 374 G.H5.26
Hydrophobic TM3 R 131 3x50 G.H5 L 373 G.H5.25
Polar ICL2 R 143 34x55 G.hns1 G 41 G.hns1.03
Hydrophobic ICL2 R 143 34x55 G.hns1 G 41 G.hns1.03
Van-der-waals ICL2 R 143 34x55 G.hns1 G 41 G.hns1.03
Hydrophobic ICL2 R 145 34x57 G.H5 I 371 G.H5.23
Ionic H8 E 306 8x48 G.h4s6 R 335 G.h4s6.17
Polar H8 E 306 8x48 G.h4s6 R 335 G.h4s6.17
Hydrophobic H8 E 306 8x48 G.h4s6 R 335 G.h4s6.17
Van-der-waals H8 E 306 8x48 G.h4s6 R 335 G.h4s6.17
Hydrophobic TM3 A 134 3x53 G.H5 Y 367 G.H5.19
Van-der-waals TM3 A 134 3x53 G.H5 Y 367 G.H5.19
Hydrophobic TM6 L 240 6x36 G.H5 L 373 G.H5.25
Hydrophobic TM2 I 67 2x37 G.H5 E 370 G.H5.22
Van-der-waals TM2 I 67 2x37 G.H5 E 370 G.H5.22
Hydrophobic TM6 I 241 6x37 G.H5 L 373 G.H5.25
Ionic ICL2 R 145 34x57 G.H5 E 370 G.H5.22
Polar ICL2 R 145 34x57 G.H5 E 370 G.H5.22
Van-der-waals ICL2 R 145 34x57 G.H5 E 370 G.H5.22
Hydrophobic TM5 L 226 5x65 G.H5 L 368 G.H5.20
Polar ICL2 A 138 34x50 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 A 138 34x50 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 A 138 34x50 G.H5 Y 367 G.H5.19