Gi1 - CCR7 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 82.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Aromatic TM6 K 260 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 260 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 260 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM3 A 157 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 157 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 158 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL2 H 165 34x54 G.S1 V 34 G.S1.02
Hydrophobic ICL2 V 162 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 162 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 R 168 34x57 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 F 256 6x28 G.H5 F 354 G.H5.26
Van-der-waals TM6 F 256 6x28 G.H5 F 354 G.H5.26
Polar TM3 R 154 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 154 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 154 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 A 161 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 161 34x50 G.H5 I 344 G.H5.16
Polar TM3 A 157 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 157 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 157 3x53 G.H5 N 347 G.H5.19
Polar ICL2 R 166 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 166 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 166 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 250 5x65 G.H5 L 348 G.H5.20
Polar ICL3 N 255 - G.H5 D 341 G.H5.13
Hydrophobic TM6 F 256 6x28 G.S6 Y 320 G.S6.02
Hydrophobic TM6 A 261 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 A 169 34x58 G.HN E 28 G.HN.52
Van-der-waals ICL2 A 169 34x58 G.HN E 28 G.HN.52
Polar ICL3 R 254 - G.H5 D 341 G.H5.13
Polar TM6 F 256 6x28 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 F 256 6x28 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 F 256 6x28 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 F 256 6x28 G.H5 K 345 G.H5.17
Polar ICL2 A 161 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 158 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 158 3x54 G.H5 L 353 G.H5.25
Polar TM6 A 261 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 261 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL3 N 255 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 N 255 - G.S6 Y 320 G.S6.02
Hydrophobic TM6 F 256 6x28 G.H5 L 348 G.H5.20
Van-der-waals TM6 F 256 6x28 G.H5 L 348 G.H5.20
Hydrophobic TM6 V 264 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 264 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 I 265 6x37 G.H5 L 353 G.H5.25
Polar H8 G 330 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 G 330 8x47 G.H5 G 352 G.H5.24
Polar C-term C 358 - G.h4s6 R 313 G.h4s6.04
Hydrophobic C-term C 358 - G.h4s6 R 313 G.h4s6.04
Van-der-waals C-term C 358 - G.h4s6 R 313 G.h4s6.04
Hydrophobic ICL2 A 169 34x58 G.hns1 A 31 G.hns1.02
Polar TM2 T 91 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 91 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM6 E 257 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 E 257 6x29 G.H5 F 354 G.H5.26
Polar TM2 T 93 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 93 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 93 2x39 G.H5 C 351 G.H5.23
Ionic ICL2 R 170 - G.HN E 28 G.HN.52
Polar ICL2 R 170 - G.HN E 28 G.HN.52
Hydrophobic ICL2 R 170 - G.HN E 28 G.HN.52
Van-der-waals ICL2 R 170 - G.HN E 28 G.HN.52
Hydrophobic TM3 R 154 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 154 3x50 G.H5 L 353 G.H5.25
Polar ICL2 H 165 34x54 G.S1 E 33 G.S1.01
Van-der-waals ICL2 H 165 34x54 G.S1 E 33 G.S1.01
Hydrophobic TM5 L 250 5x65 G.H5 I 344 G.H5.16
Hydrophobic ICL2 A 161 34x50 G.H5 I 343 G.H5.15
Van-der-waals H8 G 330 8x47 G.H5 F 354 G.H5.26
Hydrophobic ICL2 A 169 34x58 G.HN G 27 G.HN.51
Ionic ICL2 R 166 34x55 G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 166 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 166 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 166 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 A 253 5x68 G.H5 D 341 G.H5.13
Polar C-term S 357 - G.h4s6 D 315 G.h4s6.09
Van-der-waals C-term S 357 - G.h4s6 D 315 G.h4s6.09
Polar ICL3 N 255 - G.S6 H 322 G.S6.04
Van-der-waals ICL3 N 255 - G.S6 H 322 G.S6.04
Hydrophobic TM3 I 158 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 158 3x54 G.H5 L 348 G.H5.20
Polar ICL2 H 165 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 H 165 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 H 165 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL3 N 255 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 N 255 - G.h4s6 E 318 G.h4s6.12
Ionic ICL2 R 168 34x57 G.H5 D 350 G.H5.22
Polar ICL2 R 168 34x57 G.H5 D 350 G.H5.22
Van-der-waals ICL2 R 168 34x57 G.H5 D 350 G.H5.22
Polar H8 V 331 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 V 331 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 V 331 8x48 G.H5 F 354 G.H5.26
Hydrophobic ICL2 H 165 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 H 165 34x54 G.S3 L 194 G.S3.01
Polar TM6 E 257 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 V 162 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 V 162 34x51 G.s2s3 K 192 G.s2s3.01
Ionic H8 K 332 8x49 G.H5 D 350 G.H5.22
Polar H8 K 332 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 K 332 8x49 G.H5 D 350 G.H5.22
Hydrophobic ICL2 H 165 34x54 G.hns1 R 32 G.hns1.03