GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL1 | V | 79 | 12x50 | G.HN | G | 27 | G.HN.51 |
Hydrophobic | TM6 | S | 248 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | S | 248 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | ICL1 | T | 77 | 12x48 | G.HN | D | 20 | G.HN.44 |
Van-der-waals | ICL1 | T | 77 | 12x48 | G.HN | D | 20 | G.HN.44 |
Polar | ICL2 | T | 156 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | T | 156 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | C-term | K | 354 | - | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | C-term | K | 354 | - | G.H3 | K | 257 | G.H3.16 |
Polar | TM3 | R | 144 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 144 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 144 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | H | 155 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Aromatic | TM6 | K | 251 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 251 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 251 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Ionic | ICL3 | K | 246 | - | G.H5 | D | 341 | G.H5.13 |
Polar | ICL3 | K | 246 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | K | 246 | - | G.H5 | D | 341 | G.H5.13 |
Polar | TM6 | A | 252 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | A | 252 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | A | 252 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | T | 156 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Ionic | ICL3 | K | 245 | - | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | C-term | L | 353 | - | G.h4s6 | K | 312 | G.h4s6.03 |
Van-der-waals | C-term | L | 353 | - | G.h4s6 | K | 312 | G.h4s6.03 |
Ionic | H8 | R | 323 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Polar | H8 | R | 323 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | H8 | R | 323 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | H8 | R | 323 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | ICL2 | M | 152 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM3 | A | 147 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | A | 147 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM6 | T | 256 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | H8 | G | 321 | 8x47 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | H8 | G | 321 | 8x47 | G.H5 | F | 354 | G.H5.26 |
Polar | H8 | E | 322 | 8x48 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | H8 | E | 322 | 8x48 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | H8 | E | 322 | 8x48 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | ICL2 | H | 155 | 34x54 | G.S1 | V | 34 | G.S1.02 |
Hydrophobic | ICL2 | M | 152 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | M | 152 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | ICL3 | K | 246 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM2 | T | 81 | 2x37 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM2 | T | 81 | 2x37 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | T | 81 | 2x37 | G.H5 | D | 350 | G.H5.22 |
Polar | ICL3 | K | 246 | - | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | H8 | G | 321 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL1 | V | 79 | 12x50 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM6 | A | 252 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM4 | R | 158 | 4x35 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | TM4 | R | 158 | 4x35 | G.hns1 | A | 31 | G.hns1.02 |
Polar | C-term | E | 350 | - | G.h4s6 | R | 313 | G.h4s6.04 |
Van-der-waals | C-term | E | 350 | - | G.h4s6 | R | 313 | G.h4s6.04 |
Polar | ICL2 | H | 155 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | H | 155 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | H | 155 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM5 | L | 241 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM3 | R | 144 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 144 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | M | 152 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | ICL2 | M | 152 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | ICL2 | M | 152 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | M | 152 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | ICL2 | M | 152 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | A | 151 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM4 | E | 159 | 4x36 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | E | 159 | 4x36 | G.HN | E | 28 | G.HN.52 |
Polar | TM6 | S | 247 | 6x28 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | S | 247 | 6x28 | G.h4s6 | E | 318 | G.h4s6.12 |
Ionic | H8 | R | 326 | 8x52 | G.h3s5 | D | 261 | G.h3s5.02 |
Polar | H8 | R | 326 | 8x52 | G.h3s5 | D | 261 | G.h3s5.02 |
Van-der-waals | H8 | R | 326 | 8x52 | G.h3s5 | D | 261 | G.h3s5.02 |
Hydrophobic | ICL2 | A | 151 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | A | 151 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL3 | K | 246 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | K | 246 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | ICL2 | H | 155 | 34x54 | G.S1 | E | 33 | G.S1.01 |
Polar | TM3 | A | 147 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 147 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 147 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | I | 148 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | I | 148 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Ionic | TM4 | E | 159 | 4x36 | G.hns1 | R | 32 | G.hns1.03 |
Polar | TM4 | E | 159 | 4x36 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM4 | E | 159 | 4x36 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | TM4 | E | 159 | 4x36 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | H | 155 | 34x54 | G.S3 | L | 194 | G.S3.01 |
Ionic | ICL2 | R | 153 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | ICL2 | R | 153 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 153 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 153 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | TM2 | T | 83 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | T | 83 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | T | 83 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | H | 155 | 34x54 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | T | 156 | 34x55 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | TM3 | I | 148 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | I | 148 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Polar | ICL2 | A | 151 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | A | 151 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Ionic | TM4 | R | 158 | 4x35 | G.H5 | D | 350 | G.H5.22 |
Polar | TM4 | R | 158 | 4x35 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM4 | R | 158 | 4x35 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM6 | V | 255 | 6x36 | G.H5 | L | 353 | G.H5.25 |