G15 - CELSR2 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 61.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.5
PAE mean: 18.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 V 2471 - G.H5 V 363 G.H5.15
Hydrophobic TM6 V 2559 6x36 G.H5 L 373 G.H5.25
Hydrophobic C-term L 2888 - G.s6h5 T 347 G.s6h5.04
Van-der-waals C-term L 2888 - G.s6h5 T 347 G.s6h5.04
Polar C-term A 2904 - G.S2 E 194 G.S2.03
Hydrophobic C-term A 2904 - G.S2 E 194 G.S2.03
Van-der-waals C-term A 2904 - G.S2 E 194 G.S2.03
Hydrophobic C-term G 2905 - G.S2 N 193 G.S2.02
Van-der-waals C-term G 2905 - G.S2 N 193 G.S2.02
Hydrophobic C-term K 2903 - G.S2 Y 195 G.S2.04
Van-der-waals C-term K 2903 - G.S2 Y 195 G.S2.04
Hydrophobic C-term Y 2644 - G.S2 E 194 G.S2.03
Van-der-waals C-term Y 2644 - G.S2 E 194 G.S2.03
Polar ICL2 R 2472 - G.S3 N 203 G.S3.02
Polar TM5 G 2552 5x68 G.h4s6 R 338 G.h4s6.20
Hydrophobic TM5 G 2552 5x68 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM5 G 2552 5x68 G.h4s6 R 338 G.h4s6.20
Ionic H8 K 2618 8x52 G.H5 D 369 G.H5.21
Polar H8 K 2618 8x52 G.H5 D 369 G.H5.21
Hydrophobic TM3 L 2464 3x54 G.H5 I 371 G.H5.23
Hydrophobic TM5 A 2548 5x64 G.H5 L 364 G.H5.16
Polar ICL2 V 2474 - G.H5 Y 367 G.H5.19
Van-der-waals ICL2 V 2474 - G.H5 Y 367 G.H5.19
Hydrophobic ICL3 F 2553 - G.H5 L 368 G.H5.20
Van-der-waals ICL3 F 2553 - G.H5 L 368 G.H5.20
Hydrophobic C-term Y 2656 - H.hbhc Y 122 H.hbhc.01
Van-der-waals C-term Y 2656 - H.hbhc Y 122 H.hbhc.01
Polar C-term Y 2644 - G.S3 R 205 G.S3.04
Hydrophobic C-term Y 2644 - G.S3 R 205 G.S3.04
Van-der-waals C-term Y 2644 - G.S3 R 205 G.S3.04
Hydrophobic TM3 L 2468 3x58 G.H5 L 364 G.H5.16
Hydrophobic C-term V 2895 - G.H1 I 65 G.H1.11
Hydrophobic C-term M 2900 - G.S2 F 197 G.S2.06
Van-der-waals C-term M 2900 - G.S2 F 197 G.S2.06
Polar TM7 L 2612 7x60 G.H5 N 372 G.H5.24
Van-der-waals TM7 L 2612 7x60 G.H5 N 372 G.H5.24
Polar C-term Q 2657 - H.hbhc K 123 H.hbhc.02
Hydrophobic C-term Q 2657 - H.hbhc K 123 H.hbhc.02
Van-der-waals C-term Q 2657 - H.hbhc K 123 H.hbhc.02
Hydrophobic C-term I 2902 - G.h1ha G 67 G.h1ha.01
Polar H8 K 2614 8x48 G.H5 L 374 G.H5.26
Van-der-waals H8 K 2614 8x48 G.H5 L 374 G.H5.26
Hydrophobic ICL2 V 2471 - G.H5 R 360 G.H5.12
Van-der-waals ICL2 V 2471 - G.H5 R 360 G.H5.12
Hydrophobic C-term Y 2644 - G.HN Q 35 G.HN.50
Van-der-waals C-term Y 2644 - G.HN Q 35 G.HN.50
Aromatic C-term Y 2650 - G.H1 R 63 G.H1.09
Van-der-waals C-term Y 2650 - G.H1 R 63 G.H1.09
Hydrophobic C-term L 2888 - H.HF Q 180 H.HF.02
Hydrophobic C-term I 2898 - G.S2 S 198 G.S2.07
Van-der-waals C-term I 2898 - G.S2 S 198 G.S2.07
Polar ICL2 T 2476 - G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 T 2476 - G.hns1 R 40 G.hns1.02
Van-der-waals ICL2 T 2476 - G.hns1 R 40 G.hns1.02
Polar C-term Y 2650 - G.h1ha Y 70 G.h1ha.04
Hydrophobic C-term Y 2650 - G.h1ha Y 70 G.h1ha.04
Van-der-waals C-term Y 2650 - G.h1ha Y 70 G.h1ha.04
Hydrophobic C-term I 2902 - G.H1 R 63 G.H1.09
Van-der-waals C-term I 2902 - G.H1 R 63 G.H1.09
Hydrophobic C-term T 2641 - G.HN I 28 G.HN.43
Polar C-term M 2900 - G.H1 H 66 G.H1.12
Hydrophobic C-term M 2900 - G.H1 H 66 G.H1.12
Van-der-waals C-term M 2900 - G.H1 H 66 G.H1.12
Hydrophobic TM6 S 2560 6x37 G.H5 L 373 G.H5.25
Hydrophobic ICL2 V 2471 - G.H5 F 356 G.H5.08
Van-der-waals ICL2 V 2471 - G.H5 F 356 G.H5.08
Hydrophobic C-term Y 2650 - H.HA F 78 H.HA.07
Van-der-waals C-term Y 2650 - H.HA F 78 H.HA.07
Hydrophobic TM5 A 2548 5x64 G.H5 L 368 G.H5.20
Ionic C-term R 2885 - G.HG E 283 G.HG.05
Polar C-term R 2885 - G.HG E 283 G.HG.05
Van-der-waals C-term R 2885 - G.HG E 283 G.HG.05
Hydrophobic ICL3 F 2553 - G.H5 L 364 G.H5.16
Hydrophobic C-term L 2888 - H.HF L 183 H.HF.05
Hydrophobic TM3 L 2468 3x58 G.H5 L 368 G.H5.20
Van-der-waals TM3 L 2468 3x58 G.H5 L 368 G.H5.20
Hydrophobic C-term L 2655 - H.HA Q 84 H.HA.13
Van-der-waals C-term L 2655 - H.HA Q 84 H.HA.13
Hydrophobic ICL3 E 2554 - G.H5 L 374 G.H5.26
Van-der-waals ICL3 E 2554 - G.H5 L 374 G.H5.26
Hydrophobic C-term L 2634 - G.HN R 3 G.HN.03
Hydrophobic ICL2 V 2471 - G.S1 L 43 G.S1.02
Van-der-waals ICL2 V 2471 - G.S1 L 43 G.S1.02
Hydrophobic C-term M 2900 - G.H1 M 62 G.H1.08
Van-der-waals C-term M 2900 - G.H1 M 62 G.H1.08
Hydrophobic ICL2 V 2471 - G.S3 T 202 G.S3.01
Hydrophobic TM3 L 2468 3x58 G.H5 L 373 G.H5.25
Aromatic ICL3 F 2553 - G.h4s6 R 338 G.h4s6.20
Hydrophobic ICL3 F 2553 - G.h4s6 R 338 G.h4s6.20
Van-der-waals ICL3 F 2553 - G.h4s6 R 338 G.h4s6.20
Hydrophobic C-term I 2902 - G.S2 Y 195 G.S2.04
Polar C-term M 2900 - G.S2 S 198 G.S2.07
Hydrophobic C-term M 2900 - G.S2 S 198 G.S2.07
Van-der-waals C-term M 2900 - G.S2 S 198 G.S2.07
Polar ICL2 R 2472 - G.s2s3 K 201 G.s2s3.02
Hydrophobic ICL2 R 2472 - G.s2s3 K 201 G.s2s3.02
Van-der-waals ICL2 R 2472 - G.s2s3 K 201 G.s2s3.02
Hydrophobic C-term K 2637 - G.HN L 32 G.HN.47
Van-der-waals C-term K 2637 - G.HN L 32 G.HN.47
Hydrophobic C-term L 2892 - G.H1 I 65 G.H1.11
Hydrophobic ICL3 K 2556 - G.h4s6 R 335 G.h4s6.17
Van-der-waals ICL3 K 2556 - G.h4s6 R 335 G.h4s6.17
Hydrophobic ICL2 R 2472 - G.S1 L 43 G.S1.02
Polar C-term I 2898 - G.h1ha G 67 G.h1ha.01
Van-der-waals C-term K 2903 - G.S2 E 194 G.S2.03
Hydrophobic TM6 G 2561 6x38 G.H5 I 371 G.H5.23
Van-der-waals TM6 G 2561 6x38 G.H5 I 371 G.H5.23
Van-der-waals C-term S 2901 - G.S2 C 196 G.S2.05
Polar C-term G 2905 - G.S2 E 194 G.S2.03
Van-der-waals C-term G 2905 - G.S2 E 194 G.S2.03
Polar C-term I 2902 - G.S2 C 196 G.S2.05
Hydrophobic C-term I 2902 - G.S2 C 196 G.S2.05
Van-der-waals C-term I 2902 - G.S2 C 196 G.S2.05
Polar ICL2 N 2475 - G.H5 E 370 G.H5.22
Van-der-waals ICL2 N 2475 - G.H5 E 370 G.H5.22
Hydrophobic C-term I 2898 - G.H1 H 66 G.H1.12
Van-der-waals C-term I 2898 - G.H1 H 66 G.H1.12
Ionic C-term R 2885 - G.HG E 284 G.HG.06
Polar C-term R 2885 - G.HG E 284 G.HG.06
Van-der-waals C-term R 2885 - G.HG E 284 G.HG.06
Hydrophobic C-term Q 2657 - H.hbhc Y 122 H.hbhc.01
Hydrophobic C-term M 2900 - G.S2 V 199 G.S2.08
Van-der-waals C-term M 2900 - G.S2 V 199 G.S2.08
Polar ICL2 R 2472 - G.hns1 G 41 G.hns1.03
Hydrophobic C-term L 2655 - H.hbhc T 125 H.hbhc.04
Hydrophobic C-term I 2898 - G.S2 V 199 G.S2.08
Hydrophobic C-term L 2655 - H.hbhc Y 122 H.hbhc.01
Van-der-waals C-term L 2655 - H.hbhc Y 122 H.hbhc.01
Polar ICL3 K 2556 - G.H5 L 373 G.H5.25
Hydrophobic ICL3 K 2556 - G.H5 L 373 G.H5.25
Hydrophobic ICL3 K 2556 - G.H5 L 374 G.H5.26
Van-der-waals ICL3 K 2556 - G.H5 L 374 G.H5.26
Hydrophobic C-term M 2900 - G.h1ha G 67 G.h1ha.01
Van-der-waals C-term M 2900 - G.h1ha G 67 G.h1ha.01
Hydrophobic C-term I 2902 - G.S2 F 197 G.S2.06
Van-der-waals C-term I 2902 - G.S2 F 197 G.S2.06
Polar ICL2 D 2473 - G.H5 Y 367 G.H5.19
Hydrophobic ICL2 D 2473 - G.H5 Y 367 G.H5.19
Van-der-waals ICL2 D 2473 - G.H5 Y 367 G.H5.19
Hydrophobic TM6 G 2561 6x38 G.H5 L 373 G.H5.25
Van-der-waals TM6 G 2561 6x38 G.H5 L 373 G.H5.25
Polar ICL1 R 2405 12x51 G.hns1 R 40 G.hns1.02
Polar H8 K 2614 8x48 G.H5 N 372 G.H5.24
Hydrophobic H8 K 2614 8x48 G.H5 N 372 G.H5.24
Van-der-waals H8 K 2614 8x48 G.H5 N 372 G.H5.24
Polar C-term M 2900 - G.h1ha A 68 G.h1ha.02
Polar C-term K 2637 - G.HN N 29 G.HN.44
Van-der-waals C-term K 2637 - G.HN N 29 G.HN.44
Hydrophobic TM3 A 2467 3x57 G.H5 Y 367 G.H5.19
Van-der-waals TM3 A 2467 3x57 G.H5 Y 367 G.H5.19
Ionic H8 K 2614 8x48 G.H5 D 369 G.H5.21
Polar H8 K 2614 8x48 G.H5 D 369 G.H5.21
Van-der-waals H8 K 2614 8x48 G.H5 D 369 G.H5.21
Polar ICL2 N 2475 - G.H5 Y 367 G.H5.19
Hydrophobic ICL2 N 2475 - G.H5 Y 367 G.H5.19
Van-der-waals ICL2 N 2475 - G.H5 Y 367 G.H5.19
Hydrophobic C-term P 2658 - H.HB D 120 H.HB.13
Hydrophobic C-term L 2655 - H.hbhc V 124 H.hbhc.03
Polar C-term R 2885 - G.HG D 280 G.HG.02
Hydrophobic C-term V 2895 - G.H1 H 66 G.H1.12
Van-der-waals C-term V 2895 - G.H1 H 66 G.H1.12
Polar C-term A 2899 - G.S2 S 198 G.S2.07
Hydrophobic C-term A 2899 - G.S2 S 198 G.S2.07
Van-der-waals C-term A 2899 - G.S2 S 198 G.S2.07
Polar C-term V 2907 - G.S2 I 192 G.S2.01
Van-der-waals C-term V 2907 - G.S2 I 192 G.S2.01
Hydrophobic ICL2 R 2472 - G.S3 T 202 G.S3.01
Hydrophobic C-term L 2892 - G.H1 I 64 G.H1.10
Polar C-term K 2903 - G.S2 C 196 G.S2.05
Hydrophobic C-term K 2903 - G.S2 C 196 G.S2.05
Van-der-waals C-term K 2903 - G.S2 C 196 G.S2.05
Hydrophobic C-term T 2906 - G.S2 N 193 G.S2.02
Van-der-waals C-term T 2906 - G.S2 N 193 G.S2.02
Hydrophobic C-term K 2637 - G.HN R 3 G.HN.03
Van-der-waals C-term K 2637 - G.HN R 3 G.HN.03
Hydrophobic TM6 P 2558 6x35 G.H5 L 373 G.H5.25
Van-der-waals TM6 P 2558 6x35 G.H5 L 373 G.H5.25
Hydrophobic ICL3 F 2553 - G.H5 A 365 G.H5.17
Hydrophobic C-term L 2655 - H.hbhc K 123 H.hbhc.02
Polar C-term Q 2891 - G.H5 T 349 G.H5.01
Hydrophobic C-term Q 2891 - G.H5 T 349 G.H5.01
Van-der-waals C-term Q 2891 - G.H5 T 349 G.H5.01
Hydrophobic C-term M 2900 - G.H5 I 352 G.H5.04
Hydrophobic C-term A 2904 - G.S2 Y 195 G.S2.04
Van-der-waals C-term A 2904 - G.S2 Y 195 G.S2.04
Aromatic C-term F 2918 - G.H2 K 217 G.H2.05
Hydrophobic C-term F 2918 - G.H2 K 217 G.H2.05
Hydrophobic C-term P 2658 - H.hbhc Y 122 H.hbhc.01
Hydrophobic ICL3 F 2553 - G.H5 D 361 G.H5.13
Van-der-waals ICL3 F 2553 - G.H5 D 361 G.H5.13