G15 - chemerin receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 247 5x65 G.H5 L 373 G.H5.25
Polar ICL2 Q 148 34x54 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 Q 148 34x54 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 Q 148 34x54 G.H5 Y 367 G.H5.19
Hydrophobic TM4 S 152 4x38 G.hns1 R 40 G.hns1.02
Hydrophobic TM3 S 140 3x53 G.H5 Y 367 G.H5.19
Van-der-waals TM3 S 140 3x53 G.H5 Y 367 G.H5.19
Polar ICL2 N 149 34x55 G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 N 149 34x55 G.hns1 R 40 G.hns1.02
Van-der-waals ICL2 N 149 34x55 G.hns1 R 40 G.hns1.02
Polar TM3 R 137 3x50 G.H5 I 371 G.H5.23
Hydrophobic TM3 R 137 3x50 G.H5 I 371 G.H5.23
Van-der-waals TM3 R 137 3x50 G.H5 I 371 G.H5.23
Hydrophobic ICL2 P 144 34x50 G.H5 L 364 G.H5.16
Hydrophobic ICL2 Q 148 34x54 G.H5 V 363 G.H5.15
Hydrophobic ICL2 R 151 34x57 G.H5 Y 367 G.H5.19
Hydrophobic TM5 L 247 5x65 G.H5 L 368 G.H5.20
Van-der-waals TM5 L 247 5x65 G.H5 L 368 G.H5.20
Hydrophobic ICL2 N 149 34x55 G.S1 L 43 G.S1.02
Van-der-waals ICL2 N 149 34x55 G.S1 L 43 G.S1.02
Polar H8 Q 321 8x48 G.h4s6 R 335 G.h4s6.17
Hydrophobic H8 Q 321 8x48 G.h4s6 R 335 G.h4s6.17
Van-der-waals H8 Q 321 8x48 G.h4s6 R 335 G.h4s6.17
Hydrophobic TM6 P 258 6x33 G.H5 L 373 G.H5.25
Polar TM2 N 74 2x39 G.H5 E 370 G.H5.22
Hydrophobic TM2 N 74 2x39 G.H5 E 370 G.H5.22
Van-der-waals TM2 N 74 2x39 G.H5 E 370 G.H5.22
Hydrophobic TM6 F 259 6x34 G.H5 L 373 G.H5.25
Van-der-waals TM6 F 259 6x34 G.H5 L 373 G.H5.25
Hydrophobic ICL2 V 145 34x51 G.S3 T 202 G.S3.01
Van-der-waals ICL2 V 145 34x51 G.S3 T 202 G.S3.01
Hydrophobic ICL3 L 252 - G.H5 L 364 G.H5.16
Hydrophobic ICL2 V 145 34x51 G.H5 R 360 G.H5.12
Hydrophobic ICL3 L 252 - G.H5 A 365 G.H5.17
Polar ICL2 S 147 34x53 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 S 147 34x53 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 S 147 34x53 G.H5 Y 367 G.H5.19
Hydrophobic TM6 I 261 6x36 G.H5 N 372 G.H5.24
Hydrophobic TM5 I 243 5x61 G.H5 L 373 G.H5.25
Polar TM2 T 72 2x37 G.H5 E 370 G.H5.22
Polar TM6 F 259 6x34 G.H5 N 372 G.H5.24
Van-der-waals TM6 F 259 6x34 G.H5 N 372 G.H5.24
Polar H8 Q 321 8x48 G.H5 N 372 G.H5.24
Polar ICL2 N 149 34x55 G.hns1 G 41 G.hns1.03
Hydrophobic ICL2 N 149 34x55 G.hns1 G 41 G.hns1.03
Van-der-waals ICL2 N 149 34x55 G.hns1 G 41 G.hns1.03
Hydrophobic ICL3 T 255 - G.H5 L 374 G.H5.26
Van-der-waals ICL3 T 255 - G.H5 L 374 G.H5.26
Van-der-waals TM5 N 250 5x68 G.H5 L 364 G.H5.16
Hydrophobic TM3 V 141 3x54 G.H5 I 371 G.H5.23
Hydrophobic TM3 V 141 3x54 G.H5 L 368 G.H5.20
Hydrophobic ICL2 V 145 34x51 G.S1 L 43 G.S1.02
Hydrophobic ICL2 Q 148 34x54 G.S1 L 43 G.S1.02
Van-der-waals ICL2 Q 148 34x54 G.S1 L 43 G.S1.02
Hydrophobic TM6 P 258 6x33 G.H5 L 374 G.H5.26
Van-der-waals TM6 P 258 6x33 G.H5 L 374 G.H5.26
Hydrophobic TM3 V 141 3x54 G.H5 L 364 G.H5.16
Van-der-waals TM3 V 141 3x54 G.H5 L 364 G.H5.16
Hydrophobic ICL2 P 144 34x50 G.H5 V 363 G.H5.15
Van-der-waals ICL2 P 144 34x50 G.H5 V 363 G.H5.15
Polar ICL2 Q 148 34x54 G.H5 R 366 G.H5.18
Van-der-waals ICL2 Q 148 34x54 G.H5 R 366 G.H5.18
Hydrophobic TM6 P 258 6x33 G.H5 N 372 G.H5.24
Van-der-waals TM6 P 258 6x33 G.H5 N 372 G.H5.24
Ionic ICL2 R 151 34x57 G.H5 E 370 G.H5.22
Polar ICL2 R 151 34x57 G.H5 E 370 G.H5.22
Van-der-waals ICL2 R 151 34x57 G.H5 E 370 G.H5.22
Polar ICL3 L 252 - G.h4s6 R 338 G.h4s6.20
Hydrophobic ICL3 L 252 - G.h4s6 R 338 G.h4s6.20
Van-der-waals ICL3 L 252 - G.h4s6 R 338 G.h4s6.20
Hydrophobic ICL2 P 144 34x50 G.H5 R 360 G.H5.12
Van-der-waals ICL2 P 144 34x50 G.H5 R 360 G.H5.12
Hydrophobic ICL3 L 252 - G.H5 D 361 G.H5.13
Van-der-waals ICL3 L 252 - G.H5 D 361 G.H5.13
Hydrophobic ICL2 Q 148 34x54 G.h2s4 I 227 G.h2s4.05
Hydrophobic ICL2 P 144 34x50 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 P 144 34x50 G.H5 Y 367 G.H5.19