G15 - chemerin receptor 2 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 H 138 3x53 G.H5 L 364 G.H5.16
Hydrophobic ICL3 I 238 - G.H5 L 364 G.H5.16
Van-der-waals ICL3 I 238 - G.H5 L 364 G.H5.16
Hydrophobic ICL3 I 238 - G.H5 L 368 G.H5.20
Van-der-waals ICL3 I 238 - G.H5 L 368 G.H5.20
Hydrophobic ICL2 H 146 34x54 G.S1 L 43 G.S1.02
Van-der-waals ICL2 H 146 34x54 G.S1 L 43 G.S1.02
Polar TM6 H 244 6x33 G.H5 L 373 G.H5.25
Hydrophobic TM6 H 244 6x33 G.H5 L 373 G.H5.25
Van-der-waals TM6 H 244 6x33 G.H5 L 373 G.H5.25
Hydrophobic ICL2 P 142 34x50 G.H5 L 364 G.H5.16
Hydrophobic ICL2 R 147 34x55 G.hns1 G 41 G.hns1.03
Hydrophobic TM5 R 236 5x68 G.H5 R 360 G.H5.12
Van-der-waals TM5 R 236 5x68 G.H5 R 360 G.H5.12
Hydrophobic TM6 I 248 6x37 G.H5 L 373 G.H5.25
Polar TM3 H 135 3x50 G.H5 Y 367 G.H5.19
Hydrophobic TM3 H 135 3x50 G.H5 Y 367 G.H5.19
Van-der-waals TM3 H 135 3x50 G.H5 Y 367 G.H5.19
Hydrophobic TM3 L 139 3x54 G.H5 L 364 G.H5.16
Polar H8 S 308 8x47 G.H5 N 372 G.H5.24
Hydrophobic H8 S 308 8x47 G.H5 N 372 G.H5.24
Van-der-waals H8 S 308 8x47 G.H5 N 372 G.H5.24
Aromatic ICL2 H 146 34x54 G.hns1 R 40 G.hns1.02
Polar TM3 H 138 3x53 G.H5 Y 367 G.H5.19
Aromatic TM3 H 138 3x53 G.H5 Y 367 G.H5.19
Hydrophobic TM3 H 138 3x53 G.H5 Y 367 G.H5.19
Van-der-waals TM3 H 138 3x53 G.H5 Y 367 G.H5.19
Hydrophobic TM5 L 229 5x61 G.H5 L 373 G.H5.25
Hydrophobic TM3 H 135 3x50 G.H5 I 371 G.H5.23
Van-der-waals TM3 H 135 3x50 G.H5 I 371 G.H5.23
Hydrophobic TM5 R 236 5x68 G.H5 L 364 G.H5.16
Van-der-waals TM5 R 236 5x68 G.H5 L 364 G.H5.16
Hydrophobic TM6 S 241 6x30 G.H5 L 374 G.H5.26
Hydrophobic ICL2 H 146 34x54 G.h2s4 I 227 G.h2s4.05
Van-der-waals ICL2 H 146 34x54 G.h2s4 I 227 G.h2s4.05
Polar TM6 H 244 6x33 G.H5 L 374 G.H5.26
Hydrophobic TM6 H 244 6x33 G.H5 L 374 G.H5.26
Van-der-waals TM6 H 244 6x33 G.H5 L 374 G.H5.26
Polar TM2 T 70 2x37 G.H5 E 370 G.H5.22
Van-der-waals TM2 T 70 2x37 G.H5 E 370 G.H5.22
Hydrophobic TM4 T 150 4x38 G.hns1 R 40 G.hns1.02
Van-der-waals TM4 T 150 4x38 G.hns1 R 40 G.hns1.02
Polar ICL2 R 147 34x55 G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 R 147 34x55 G.hns1 R 40 G.hns1.02
Van-der-waals ICL2 R 147 34x55 G.hns1 R 40 G.hns1.02
Ionic ICL2 R 149 34x57 G.H5 E 370 G.H5.22
Polar ICL2 R 149 34x57 G.H5 E 370 G.H5.22
Hydrophobic ICL2 R 149 34x57 G.H5 E 370 G.H5.22
Van-der-waals ICL2 R 149 34x57 G.H5 E 370 G.H5.22
Ionic TM5 R 236 5x68 G.H5 D 361 G.H5.13
Polar TM5 R 236 5x68 G.H5 D 361 G.H5.13
Hydrophobic TM5 R 236 5x68 G.H5 D 361 G.H5.13
Van-der-waals TM5 R 236 5x68 G.H5 D 361 G.H5.13
Hydrophobic ICL2 P 142 34x50 G.H5 R 360 G.H5.12
Van-der-waals ICL2 P 142 34x50 G.H5 R 360 G.H5.12
Hydrophobic ICL3 I 238 - G.h4s6 R 338 G.h4s6.20
Van-der-waals ICL3 I 238 - G.h4s6 R 338 G.h4s6.20
Polar TM2 T 72 2x39 G.H5 E 370 G.H5.22
Van-der-waals TM2 T 72 2x39 G.H5 E 370 G.H5.22
Hydrophobic ICL2 H 146 34x54 G.H5 V 363 G.H5.15
Hydrophobic ICL2 V 143 34x51 G.S3 T 202 G.S3.01
Van-der-waals ICL2 V 143 34x51 G.S3 T 202 G.S3.01
Polar H8 K 310 8x49 G.H5 N 372 G.H5.24
Hydrophobic H8 K 310 8x49 G.H5 N 372 G.H5.24
Van-der-waals H8 K 310 8x49 G.H5 N 372 G.H5.24
Polar TM3 D 134 3x49 G.H5 Y 367 G.H5.19
Hydrophobic TM3 D 134 3x49 G.H5 Y 367 G.H5.19
Van-der-waals TM3 D 134 3x49 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 R 149 34x57 G.H5 Y 367 G.H5.19
Hydrophobic TM2 T 72 2x39 G.H5 I 371 G.H5.23
Polar TM6 H 244 6x33 G.H5 N 372 G.H5.24
Hydrophobic TM6 H 244 6x33 G.H5 N 372 G.H5.24
Van-der-waals TM6 H 244 6x33 G.H5 N 372 G.H5.24
Polar H8 K 309 8x48 G.H5 N 372 G.H5.24
Ionic H8 K 310 8x49 G.H5 D 369 G.H5.21
Polar H8 K 310 8x49 G.H5 D 369 G.H5.21
Hydrophobic H8 K 310 8x49 G.H5 D 369 G.H5.21
Van-der-waals H8 K 310 8x49 G.H5 D 369 G.H5.21
Hydrophobic ICL3 I 240 - G.H5 L 368 G.H5.20
Hydrophobic ICL2 V 143 34x51 G.S1 L 43 G.S1.02
Van-der-waals ICL2 V 143 34x51 G.S1 L 43 G.S1.02
Hydrophobic ICL2 P 142 34x50 G.H5 V 363 G.H5.15
Van-der-waals ICL2 P 142 34x50 G.H5 V 363 G.H5.15