Golf - CXCR6 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar C-term F 340 - G.S2 E 196 G.S2.03
Van-der-waals C-term F 340 - G.S2 E 196 G.S2.03
Polar H8 K 294 8x49 G.H5 E 379 G.H5.24
Van-der-waals H8 K 294 8x49 G.H5 E 379 G.H5.24
Hydrophobic C-term T 337 - G.S2 R 198 G.S2.05
Van-der-waals C-term T 337 - G.S2 R 198 G.S2.05
Hydrophobic TM3 V 130 3x53 G.H5 Y 378 G.H5.23
Van-der-waals TM3 V 130 3x53 G.H5 Y 378 G.H5.23
Polar TM4 R 144 4x38 G.H5 Y 378 G.H5.23
Hydrophobic ICL2 T 135 34x51 G.S3 V 204 G.S3.01
Hydrophobic ICL2 A 134 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 Y 138 34x54 G.H5 H 374 G.H5.19
Hydrophobic ICL3 F 224 - G.H5 R 372 G.H5.17
Van-der-waals ICL3 F 224 - G.H5 R 372 G.H5.17
Hydrophobic ICL2 T 135 34x51 G.H5 I 370 G.H5.15
Polar H8 L 293 8x48 G.H5 E 379 G.H5.24
Hydrophobic H8 L 293 8x48 G.H5 E 379 G.H5.24
Van-der-waals H8 L 293 8x48 G.H5 E 379 G.H5.24
Polar TM3 V 131 3x54 G.H5 Q 371 G.H5.16
Hydrophobic TM3 V 131 3x54 G.H5 Q 371 G.H5.16
Van-der-waals TM3 V 131 3x54 G.H5 Q 371 G.H5.16
Polar ICL2 N 139 34x55 G.S1 H 43 G.S1.02
Polar ICL2 A 134 34x50 G.H5 H 374 G.H5.19
Hydrophobic ICL2 A 134 34x50 G.H5 H 374 G.H5.19
Van-der-waals ICL2 A 134 34x50 G.H5 H 374 G.H5.19
Hydrophobic ICL2 Y 138 34x54 G.H5 I 370 G.H5.15
Polar ICL3 G 223 - G.H5 R 372 G.H5.17
Hydrophobic C-term S 329 - G.HN L 32 G.HN.47
Van-der-waals C-term S 329 - G.HN L 32 G.HN.47
Polar TM3 D 126 3x49 G.H5 Y 378 G.H5.23
Hydrophobic TM3 D 126 3x49 G.H5 Y 378 G.H5.23
Van-der-waals TM3 D 126 3x49 G.H5 Y 378 G.H5.23
Hydrophobic TM6 I 233 6x37 G.H5 L 380 G.H5.25
Hydrophobic ICL2 T 135 34x51 G.H5 R 367 G.H5.12
Hydrophobic C-term M 339 - G.H1 V 59 G.H1.05
Polar C-term Q 341 - G.hfs2 S 192 G.hfs2.06
Van-der-waals C-term Q 341 - G.hfs2 S 192 G.hfs2.06
Polar H8 S 292 8x47 G.H5 E 379 G.H5.24
Hydrophobic H8 S 292 8x47 G.H5 E 379 G.H5.24
Van-der-waals H8 S 292 8x47 G.H5 E 379 G.H5.24
Hydrophobic TM3 V 131 3x54 G.H5 L 380 G.H5.25
Hydrophobic C-term L 342 - G.S3 F 209 G.S3.06
Hydrophobic TM3 V 131 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 V 131 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 A 137 34x53 G.H5 H 374 G.H5.19
Polar ICL2 N 139 34x55 G.hns1 A 41 G.hns1.03
Hydrophobic ICL2 N 139 34x55 G.hns1 A 41 G.hns1.03
Van-der-waals ICL2 N 139 34x55 G.hns1 A 41 G.hns1.03
Hydrophobic ICL3 F 224 - G.H5 L 375 G.H5.20
Van-der-waals ICL3 F 224 - G.H5 L 375 G.H5.20
Hydrophobic TM6 I 232 6x36 G.H5 L 380 G.H5.25
Hydrophobic C-term S 331 - G.HN E 35 G.HN.50
Hydrophobic C-term H 332 - G.HN A 38 G.HN.53
Van-der-waals C-term H 332 - G.HN A 38 G.HN.53
Hydrophobic TM2 T 66 2x39 G.H5 Y 378 G.H5.23
Van-der-waals TM2 T 66 2x39 G.H5 Y 378 G.H5.23
Hydrophobic ICL2 A 142 34x58 G.HN L 37 G.HN.52
Van-der-waals ICL2 A 142 34x58 G.HN L 37 G.HN.52
Hydrophobic ICL2 A 134 34x50 G.H5 Q 371 G.H5.16
Van-der-waals ICL2 A 134 34x50 G.H5 Q 371 G.H5.16
Hydrophobic ICL3 F 224 - G.H5 L 381 G.H5.26
Van-der-waals ICL3 F 224 - G.H5 L 381 G.H5.26
Polar C-term L 342 - G.S2 I 194 G.S2.01
Hydrophobic C-term L 342 - G.S2 I 194 G.S2.01
Van-der-waals C-term L 342 - G.S2 I 194 G.S2.01
Hydrophobic C-term T 337 - G.h1ha V 67 G.h1ha.01
Hydrophobic C-term M 339 - G.H1 R 63 G.H1.09
Van-der-waals C-term M 339 - G.H1 R 63 G.H1.09
Polar TM3 V 130 3x53 G.H5 H 374 G.H5.19
Hydrophobic TM3 V 130 3x53 G.H5 H 374 G.H5.19
Van-der-waals TM3 V 130 3x53 G.H5 H 374 G.H5.19
Hydrophobic TM5 L 218 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 218 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM5 T 217 5x64 G.H5 Q 371 G.H5.16
Polar TM6 S 229 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM6 S 229 6x33 G.H5 L 380 G.H5.25
Van-der-waals TM6 S 229 6x33 G.H5 L 380 G.H5.25
Hydrophobic ICL2 Y 138 34x54 G.hns1 K 40 G.hns1.02
Van-der-waals ICL2 Y 138 34x54 G.hns1 K 40 G.hns1.02
Polar ICL3 G 222 - G.H5 R 372 G.H5.17
Van-der-waals ICL3 G 222 - G.H5 R 372 G.H5.17
Hydrophobic TM3 R 127 3x50 G.H5 Y 378 G.H5.23
Hydrophobic TM6 I 232 6x36 G.H5 E 379 G.H5.24
Van-der-waals TM6 I 232 6x36 G.H5 E 379 G.H5.24
Hydrophobic TM3 R 127 3x50 G.H5 L 380 G.H5.25
Hydrophobic C-term Q 341 - G.S2 F 195 G.S2.02
Van-der-waals C-term Q 341 - G.S2 F 195 G.S2.02
Ionic C-term H 332 - G.HN E 35 G.HN.50
Polar C-term H 332 - G.HN E 35 G.HN.50
Hydrophobic C-term H 332 - G.HN E 35 G.HN.50
Van-der-waals C-term H 332 - G.HN E 35 G.HN.50
Aromatic ICL2 Y 138 34x54 G.S1 H 43 G.S1.02
Hydrophobic ICL2 Y 138 34x54 G.S1 H 43 G.S1.02
Van-der-waals ICL2 Y 138 34x54 G.S1 H 43 G.S1.02