G12 - ETB receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 S 207 34x51 G.H5 N 374 G.H5.19
Van-der-waals ICL2 S 207 34x51 G.H5 N 374 G.H5.19
Hydrophobic ICL2 S 207 34x51 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 S 207 34x51 G.hns1 R 55 G.hns1.02
Ionic TM5 E 299 5x64 G.H5 K 367 G.H5.12
Polar TM5 E 299 5x64 G.H5 K 367 G.H5.12
Van-der-waals TM5 E 299 5x64 G.H5 K 367 G.H5.12
Hydrophobic ICL2 W 206 34x50 G.H5 F 363 G.H5.08
Van-der-waals ICL2 W 206 34x50 G.H5 F 363 G.H5.08
Hydrophobic ICL2 R 208 34x52 G.H5 E 373 G.H5.18
Van-der-waals H8 K 391 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM6 V 321 6x33 G.H5 L 375 G.H5.20
Ionic TM6 H 314 6x26 G.H5 D 368 G.H5.13
Polar TM6 H 314 6x26 G.H5 D 368 G.H5.13
Van-der-waals TM6 H 314 6x26 G.H5 D 368 G.H5.13
Hydrophobic TM5 M 300 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 M 300 5x65 G.H5 L 375 G.H5.20
Hydrophobic C-term F 433 - G.H3 T 279 G.H3.11
Van-der-waals C-term F 433 - G.H3 T 279 G.H3.11
Hydrophobic H8 S 390 8x47 G.H5 Q 381 G.H5.26
Hydrophobic H8 F 393 8x50 G.H5 L 380 G.H5.25
Van-der-waals H8 F 393 8x50 G.H5 L 380 G.H5.25
Polar H8 K 391 8x48 G.H5 L 380 G.H5.25
Hydrophobic TM6 V 321 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 321 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM5 M 307 5x72 G.H5 A 365 G.H5.10
Van-der-waals TM5 M 307 5x72 G.H5 A 365 G.H5.10
Polar TM6 Q 317 6x29 G.H5 Q 372 G.H5.17
Hydrophobic TM6 Q 317 6x29 G.H5 Q 372 G.H5.17
Van-der-waals TM6 Q 317 6x29 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 K 210 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 K 210 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL3 I 309 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 I 309 - G.S6 H 348 G.S6.03
Polar TM6 R 318 6x30 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 318 6x30 G.H5 Q 372 G.H5.17
Hydrophobic ICL1 M 132 12x50 G.H5 L 380 G.H5.25
Van-der-waals ICL1 M 132 12x50 G.H5 L 380 G.H5.25
Hydrophobic TM2 P 136 2x39 G.H5 I 378 G.H5.23
Hydrophobic TM5 M 307 5x72 G.H5 F 361 G.H5.06
Van-der-waals TM5 M 307 5x72 G.H5 F 361 G.H5.06
Hydrophobic ICL2 W 206 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 W 206 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL2 W 206 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 W 206 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 I 209 34x53 G.H5 I 378 G.H5.23
Van-der-waals ICL2 I 209 34x53 G.H5 I 378 G.H5.23
Polar TM6 H 314 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 H 314 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 H 314 6x26 G.H5 Q 372 G.H5.17
Hydrophobic H8 R 392 8x49 G.H5 Q 381 G.H5.26
Polar TM3 S 205 3x56 G.H5 N 374 G.H5.19
Hydrophobic TM5 M 307 5x72 G.H5 H 364 G.H5.09
Van-der-waals TM5 M 307 5x72 G.H5 H 364 G.H5.09
Hydrophobic TM7 V 389 7x56 G.H5 M 379 G.H5.24
Hydrophobic ICL2 R 208 34x52 G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 208 34x52 G.H5 N 374 G.H5.19
Hydrophobic ICL3 A 310 - G.S6 F 347 G.S6.02
Hydrophobic ICL3 L 311 - G.H5 D 368 G.H5.13
Hydrophobic ICL2 S 207 34x51 G.H5 I 370 G.H5.15
Polar TM3 A 202 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 202 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 202 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 V 203 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 203 3x54 G.H5 L 371 G.H5.16
Ionic TM6 R 318 6x30 G.H5 D 368 G.H5.13
Polar TM6 R 318 6x30 G.H5 D 368 G.H5.13
Hydrophobic TM6 R 318 6x30 G.H5 D 368 G.H5.13
Van-der-waals TM6 R 318 6x30 G.H5 D 368 G.H5.13
Hydrophobic ICL3 A 310 - G.S6 L 346 G.S6.01
Van-der-waals ICL3 A 310 - G.S6 L 346 G.S6.01
Hydrophobic TM2 I 140 2x43 G.H5 L 380 G.H5.25
Polar TM5 K 304 5x69 G.H5 H 364 G.H5.09
Hydrophobic TM5 K 304 5x69 G.H5 H 364 G.H5.09
Van-der-waals TM5 K 304 5x69 G.H5 H 364 G.H5.09
Hydrophobic TM6 R 318 6x30 G.H5 L 371 G.H5.16
Van-der-waals TM6 R 318 6x30 G.H5 L 371 G.H5.16
Hydrophobic TM6 V 325 6x37 G.H5 M 379 G.H5.24
Hydrophobic TM5 M 307 5x72 G.S6 F 347 G.S6.02
Polar TM6 Q 317 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 Q 317 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 Q 317 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM2 N 137 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 N 137 2x40 G.H5 L 380 G.H5.25
Polar ICL2 R 208 34x52 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 W 206 34x50 G.S3 I 221 G.S3.01
Van-der-waals ICL2 W 206 34x50 G.S3 I 221 G.S3.01
Hydrophobic TM7 L 386 7x53 G.H5 L 380 G.H5.25
Polar ICL2 R 208 34x52 G.h2s4 T 246 G.h2s4.05
Hydrophobic ICL2 R 208 34x52 G.h2s4 T 246 G.h2s4.05
Van-der-waals ICL2 R 208 34x52 G.h2s4 T 246 G.h2s4.05
Hydrophobic ICL2 R 208 34x52 G.H5 I 370 G.H5.15
Hydrophobic TM3 V 203 3x54 G.H5 L 375 G.H5.20
Aromatic C-term F 423 - G.h3s5 F 287 G.h3s5.01
Hydrophobic C-term F 423 - G.h3s5 F 287 G.h3s5.01
Van-der-waals C-term F 423 - G.h3s5 F 287 G.h3s5.01
Hydrophobic ICL2 I 209 34x53 G.H5 D 377 G.H5.22
Hydrophobic C-term Y 430 - G.H2 F 239 G.H2.08
Hydrophobic H8 S 390 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 S 390 8x47 G.H5 M 379 G.H5.24
Polar TM3 R 199 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 199 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 199 3x50 G.H5 I 378 G.H5.23
Polar TM7 V 389 7x56 G.H5 Q 381 G.H5.26
Hydrophobic TM3 R 199 3x50 G.H5 M 379 G.H5.24
Polar ICL2 R 208 34x52 G.h3s5 N 288 G.h3s5.02
Van-der-waals ICL2 R 208 34x52 G.h3s5 N 288 G.h3s5.02
Hydrophobic TM6 T 324 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM6 R 318 6x30 G.H5 L 375 G.H5.20
Polar H8 R 392 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 R 392 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 R 392 8x49 G.H5 L 380 G.H5.25
Polar ICL1 N 134 12x52 G.H5 D 377 G.H5.22
Polar C-term N 437 - G.H2 Q 236 G.H2.05
Hydrophobic TM5 M 300 5x65 G.H5 L 371 G.H5.16
Polar H8 S 390 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 S 390 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 S 390 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM3 A 202 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 202 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL3 L 311 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 L 311 - G.S6 F 347 G.S6.02
Polar ICL2 I 209 34x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 I 209 34x53 G.H5 N 374 G.H5.19
Van-der-waals ICL2 I 209 34x53 G.H5 N 374 G.H5.19
Hydrophobic TM6 H 314 6x26 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 H 314 6x26 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL3 A 310 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 A 310 - G.h4s6 P 345 G.h4s6.20