Gz - FZD9 complex model

GPCR CLASS (FAMILY)

F (Frizzled)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 76.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 28.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar H8 K 532 8x49 G.h4s6 E 316 G.h4s6.09
Van-der-waals H8 K 532 8x49 G.h4s6 E 316 G.h4s6.09
Polar TM2 Y 262 2x39 G.H5 I 352 G.H5.23
Hydrophobic TM2 Y 262 2x39 G.H5 I 352 G.H5.23
Van-der-waals TM2 Y 262 2x39 G.H5 I 352 G.H5.23
Polar TM2 P 263 2x40 G.H5 Y 351 G.H5.22
Hydrophobic TM2 P 263 2x40 G.H5 Y 351 G.H5.22
Van-der-waals TM2 P 263 2x40 G.H5 Y 351 G.H5.22
Polar TM3 W 338 3x50 G.H5 I 352 G.H5.23
Polar ICL1 Q 261 12x51 G.H5 Y 351 G.H5.22
Hydrophobic ICL1 Q 261 12x51 G.H5 Y 351 G.H5.22
Van-der-waals ICL1 Q 261 12x51 G.H5 Y 351 G.H5.22
Aromatic TM4 H 348 4x35 G.H5 Y 351 G.H5.22
Hydrophobic TM4 H 348 4x35 G.H5 Y 351 G.H5.22
Van-der-waals TM4 H 348 4x35 G.H5 Y 351 G.H5.22
Ionic ICL2 K 344 - G.s2s3 E 194 G.s2s3.02
Polar ICL2 K 344 - G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 K 344 - G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 K 344 - G.s2s3 E 194 G.s2s3.02
Hydrophobic TM4 G 347 4x34 G.H5 N 348 G.H5.19
Van-der-waals TM4 G 347 4x34 G.H5 N 348 G.H5.19
Van-der-waals ICL2 W 346 - G.H5 I 352 G.H5.23
Hydrophobic TM6 L 444 6x29 G.H5 C 355 G.H5.26
Van-der-waals TM6 L 444 6x29 G.H5 C 355 G.H5.26
Polar TM2 E 264 2x41 G.H5 I 352 G.H5.23
Hydrophobic TM2 E 264 2x41 G.H5 I 352 G.H5.23
Van-der-waals TM2 E 264 2x41 G.H5 I 352 G.H5.23
Ionic ICL2 K 345 - G.H5 D 342 G.H5.13
Polar ICL2 K 345 - G.H5 D 342 G.H5.13
Hydrophobic ICL2 K 345 - G.H5 D 342 G.H5.13
Van-der-waals ICL2 K 345 - G.H5 D 342 G.H5.13
Polar ICL1 Q 261 12x51 G.h3s5 N 262 G.h3s5.02
Hydrophobic ICL1 Q 261 12x51 G.h3s5 N 262 G.h3s5.02
Van-der-waals ICL1 Q 261 12x51 G.h3s5 N 262 G.h3s5.02
Hydrophobic TM2 P 263 2x40 G.H5 N 348 G.H5.19
Van-der-waals TM2 P 263 2x40 G.H5 N 348 G.H5.19
Hydrophobic ICL2 K 345 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 K 345 - G.S3 L 195 G.S3.01
Hydrophobic TM6 L 444 6x29 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 444 6x29 G.H5 L 354 G.H5.25
Hydrophobic TM3 T 337 3x49 G.H5 I 352 G.H5.23
Van-der-waals TM3 T 337 3x49 G.H5 I 352 G.H5.23
Hydrophobic ICL2 K 345 - G.H5 I 345 G.H5.16
Van-der-waals ICL2 K 345 - G.H5 I 345 G.H5.16
Hydrophobic TM3 A 341 3x53 G.H5 L 354 G.H5.25
Van-der-waals TM3 A 341 3x53 G.H5 L 354 G.H5.25
Polar TM4 H 348 4x35 G.h3s5 N 262 G.h3s5.02
Van-der-waals TM4 H 348 4x35 G.h3s5 N 262 G.h3s5.02
Polar TM4 S 356 4x43 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 S 356 4x43 G.hns1 R 31 G.hns1.02
Polar TM4 H 348 4x35 G.H5 N 348 G.H5.19
Hydrophobic TM4 H 348 4x35 G.H5 N 348 G.H5.19
Van-der-waals TM4 H 348 4x35 G.H5 N 348 G.H5.19
Polar TM4 Y 357 4x44 G.hns1 R 31 G.hns1.02
Hydrophobic TM4 Y 357 4x44 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 Y 357 4x44 G.hns1 R 31 G.hns1.02
Hydrophobic TM2 P 263 2x40 G.H5 L 354 G.H5.25
Van-der-waals TM2 P 263 2x40 G.H5 L 354 G.H5.25
Hydrophobic N-term Q 81 - G.H2 I 213 G.H2.08
Van-der-waals N-term Q 81 - G.H2 I 213 G.H2.08
Polar ICL1 H 258 12x48 G.h3s5 N 262 G.h3s5.02
Hydrophobic ICL2 W 346 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 W 346 - G.S3 L 195 G.S3.01
Polar TM2 E 264 2x41 G.H5 Y 351 G.H5.22
Van-der-waals TM2 E 264 2x41 G.H5 Y 351 G.H5.22
Hydrophobic TM2 E 264 2x41 G.H5 G 353 G.H5.24
Van-der-waals TM2 E 264 2x41 G.H5 G 353 G.H5.24
Hydrophobic TM4 I 351 4x38 G.H5 I 352 G.H5.23
Van-der-waals TM4 I 351 4x38 G.H5 I 352 G.H5.23
Hydrophobic TM3 A 342 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 A 342 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM3 T 337 3x49 G.H5 L 354 G.H5.25
Hydrophobic TM4 G 347 4x34 G.H5 I 352 G.H5.23
Van-der-waals TM4 G 347 4x34 G.H5 I 352 G.H5.23
Hydrophobic ICL2 W 346 - G.H5 N 348 G.H5.19
Van-der-waals ICL2 W 346 - G.H5 N 348 G.H5.19
Polar TM4 E 349 4x36 G.H5 N 348 G.H5.19
Hydrophobic TM3 W 338 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 W 338 3x50 G.H5 L 354 G.H5.25
Polar TM4 E 349 4x36 G.h2s4 T 220 G.h2s4.05
Hydrophobic TM4 E 349 4x36 G.h2s4 T 220 G.h2s4.05
Van-der-waals TM4 E 349 4x36 G.h2s4 T 220 G.h2s4.05
Ionic ICL3 K 440 - G.h4s6 E 319 G.h4s6.12
Polar ICL3 K 440 - G.h4s6 E 319 G.h4s6.12
Hydrophobic TM4 A 350 4x37 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 A 350 4x37 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 W 346 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 W 346 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 I 448 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 I 448 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM4 H 348 4x35 G.S5 S 264 G.S5.01
Hydrophobic TM4 H 354 4x41 G.hns1 R 32 G.hns1.03
Polar TM4 E 349 4x36 G.h2s4 V 219 G.h2s4.04
Hydrophobic TM4 E 349 4x36 G.h2s4 V 219 G.h2s4.04
Van-der-waals TM4 E 349 4x36 G.h2s4 V 219 G.h2s4.04
Hydrophobic TM3 A 341 3x53 G.H5 L 349 G.H5.20
Van-der-waals TM3 A 341 3x53 G.H5 L 349 G.H5.20
Polar TM2 Y 262 2x39 G.H5 Y 351 G.H5.22
Hydrophobic TM2 Y 262 2x39 G.H5 Y 351 G.H5.22
Van-der-waals TM2 Y 262 2x39 G.H5 Y 351 G.H5.22
Hydrophobic TM2 P 263 2x40 G.H5 I 352 G.H5.23
Van-der-waals TM2 P 263 2x40 G.H5 I 352 G.H5.23
Polar TM4 E 349 4x36 G.h3s5 T 263 G.h3s5.03
Van-der-waals TM4 E 349 4x36 G.h3s5 T 263 G.h3s5.03
Polar N-term Q 81 - G.H2 H 214 G.H2.09
Hydrophobic N-term Q 81 - G.H2 H 214 G.H2.09
Van-der-waals N-term Q 81 - G.H2 H 214 G.H2.09
Hydrophobic TM7 W 527 7x55 G.H5 G 353 G.H5.24
Van-der-waals TM7 W 527 7x55 G.H5 G 353 G.H5.24
Hydrophobic TM3 A 341 3x53 G.H5 I 352 G.H5.23
Van-der-waals TM3 A 341 3x53 G.H5 I 352 G.H5.23
Polar TM4 E 352 4x39 G.h3s5 N 262 G.h3s5.02
Polar TM4 H 354 4x41 G.hns1 R 31 G.hns1.02
Aromatic TM4 H 354 4x41 G.hns1 R 31 G.hns1.02
Hydrophobic TM4 H 354 4x41 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 H 354 4x41 G.hns1 R 31 G.hns1.02
Polar TM4 A 353 4x40 G.hns1 R 31 G.hns1.02
Hydrophobic TM4 A 353 4x40 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 A 353 4x40 G.hns1 R 31 G.hns1.02
Polar TM4 H 348 4x35 G.H5 N 347 G.H5.18
Hydrophobic TM4 H 348 4x35 G.H5 N 347 G.H5.18
Van-der-waals TM4 H 348 4x35 G.H5 N 347 G.H5.18
Hydrophobic TM2 P 263 2x40 G.H5 L 349 G.H5.20
Van-der-waals TM2 P 263 2x40 G.H5 L 349 G.H5.20
Hydrophobic ICL1 H 258 12x48 G.h3s5 I 261 G.h3s5.01