G12 - GPR137 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 71.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 K 123 3x57 G.H5 D 377 G.H5.22
Hydrophobic TM3 K 123 3x57 G.H5 D 377 G.H5.22
Van-der-waals TM3 K 123 3x57 G.H5 D 377 G.H5.22
Hydrophobic C-term T 353 - G.HG M 298 G.HG.01
Polar C-term D 347 - G.H4 R 329 G.H4.09
Hydrophobic C-term D 347 - G.H4 R 329 G.H4.09
Van-der-waals C-term D 347 - G.H4 R 329 G.H4.09
Polar C-term S 411 - H.HA K 114 H.HA.28
Van-der-waals C-term S 411 - H.HA K 114 H.HA.28
Polar TM3 Y 116 3x50 G.H5 L 380 G.H5.25
Hydrophobic TM3 Y 116 3x50 G.H5 L 380 G.H5.25
Polar C-term C 409 - H.HA V 107 H.HA.21
Hydrophobic C-term C 409 - H.HA V 107 H.HA.21
Van-der-waals C-term C 409 - H.HA V 107 H.HA.21
Hydrophobic TM3 V 120 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 120 3x54 G.H5 I 378 G.H5.23
Hydrophobic C-term L 413 - H.HA L 115 H.HA.29
Van-der-waals C-term L 413 - H.HA L 115 H.HA.29
Hydrophobic C-term V 414 - H.hdhe F 173 H.hdhe.01
Polar TM3 A 124 3x58 G.hns1 R 55 G.hns1.02
Van-der-waals TM3 A 124 3x58 G.hns1 R 55 G.hns1.02
Hydrophobic C-term L 413 - H.HA K 114 H.HA.28
Van-der-waals C-term L 413 - H.HA K 114 H.HA.28
Hydrophobic C-term C 409 - H.HA K 103 H.HA.17
Hydrophobic C-term D 330 - G.H5 L 375 G.H5.20
Van-der-waals C-term D 330 - G.H5 L 375 G.H5.20
Polar C-term C 409 - H.HA R 106 H.HA.20
Hydrophobic C-term C 409 - H.HA R 106 H.HA.20
Van-der-waals C-term C 409 - H.HA R 106 H.HA.20
Polar TM3 K 123 3x57 G.H5 M 379 G.H5.24
Hydrophobic C-term T 353 - G.H4 L 324 G.H4.04
Van-der-waals C-term T 353 - G.H4 L 324 G.H4.04
Hydrophobic C-term V 414 - G.s4h3 V 260 G.s4h3.07
Van-der-waals C-term V 414 - G.s4h3 V 260 G.s4h3.07
Hydrophobic ICL3 I 206 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL3 I 206 - G.hns1 R 55 G.hns1.02
Hydrophobic TM2 Y 58 2x42 G.H5 L 380 G.H5.25
Hydrophobic ICL3 I 206 - G.H5 L 371 G.H5.16
Van-der-waals ICL3 I 206 - G.H5 L 371 G.H5.16
Hydrophobic C-term L 413 - H.HD E 172 H.HD.12
Van-der-waals C-term L 413 - H.HD E 172 H.HD.12
Hydrophobic TM3 V 120 3x54 G.H5 L 380 G.H5.25
Van-der-waals TM3 V 120 3x54 G.H5 L 380 G.H5.25
Polar C-term S 411 - H.HA A 111 H.HA.25
Hydrophobic C-term S 411 - H.HA A 111 H.HA.25
Van-der-waals C-term S 411 - H.HA A 111 H.HA.25
Polar TM5 R 200 5x64 G.hns1 R 55 G.hns1.02
Van-der-waals TM5 R 200 5x64 G.hns1 R 55 G.hns1.02
Ionic C-term H 410 - H.HA D 110 H.HA.24
Polar C-term H 410 - H.HA D 110 H.HA.24
Hydrophobic C-term H 410 - H.HA D 110 H.HA.24
Van-der-waals C-term H 410 - H.HA D 110 H.HA.24
Hydrophobic ICL3 Y 207 - G.H5 L 375 G.H5.20
Van-der-waals ICL3 Y 207 - G.H5 L 375 G.H5.20
Hydrophobic TM3 K 123 3x57 G.H5 I 378 G.H5.23
Van-der-waals TM3 K 123 3x57 G.H5 I 378 G.H5.23
Hydrophobic TM3 K 123 3x57 G.H5 L 380 G.H5.25
Hydrophobic ICL3 E 209 - G.s2s3 K 220 G.s2s3.02
Polar C-term V 414 - H.HD E 172 H.HD.12
Hydrophobic C-term V 414 - H.HD E 172 H.HD.12
Van-der-waals C-term V 414 - H.HD E 172 H.HD.12
Hydrophobic C-term E 412 - H.hdhe F 173 H.hdhe.01
Hydrophobic TM3 R 128 3x62 G.hns1 R 55 G.hns1.02
Van-der-waals TM3 R 128 3x62 G.hns1 R 55 G.hns1.02
Hydrophobic C-term A 349 - G.H4 R 329 G.H4.09
Van-der-waals C-term A 349 - G.H4 R 329 G.H4.09
Hydrophobic TM3 Q 119 3x53 G.H5 L 380 G.H5.25
Van-der-waals TM3 Q 119 3x53 G.H5 L 380 G.H5.25
Hydrophobic ICL3 Y 207 - G.H5 Q 372 G.H5.17
Hydrophobic TM3 V 120 3x54 G.H5 M 379 G.H5.24
Hydrophobic ICL3 T 204 - G.H5 L 375 G.H5.20
Van-der-waals ICL3 T 204 - G.H5 L 375 G.H5.20
Ionic ICL3 E 209 - G.hns1 R 56 G.hns1.03
Polar ICL3 E 209 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL3 E 209 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL3 E 209 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL3 S 203 - G.H5 I 378 G.H5.23
Van-der-waals ICL3 S 203 - G.H5 I 378 G.H5.23
Hydrophobic ICL3 I 206 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL3 I 206 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL3 I 206 - G.S3 I 221 G.S3.01
Van-der-waals ICL3 I 206 - G.S3 I 221 G.S3.01
Hydrophobic C-term D 330 - G.H5 M 379 G.H5.24
Van-der-waals C-term D 330 - G.H5 M 379 G.H5.24
Hydrophobic C-term H 410 - H.HA V 107 H.HA.21
Hydrophobic ICL3 S 203 - G.H5 L 375 G.H5.20
Hydrophobic ICL3 A 210 - G.S3 I 221 G.S3.01
Van-der-waals ICL3 A 210 - G.S3 I 221 G.S3.01
Ionic TM3 K 127 3x61 G.H5 D 377 G.H5.22
Polar TM3 K 127 3x61 G.H5 D 377 G.H5.22
Hydrophobic TM3 A 124 3x58 G.H5 I 378 G.H5.23
Hydrophobic ICL3 Y 207 - G.H5 L 371 G.H5.16
Van-der-waals ICL3 Y 207 - G.H5 L 371 G.H5.16
Hydrophobic C-term T 351 - G.S6 F 350 G.S6.05
Hydrophobic TM3 Y 116 3x50 G.H5 M 379 G.H5.24
Van-der-waals TM3 Y 116 3x50 G.H5 M 379 G.H5.24
Polar C-term S 411 - H.HA V 107 H.HA.21
Hydrophobic C-term S 411 - H.HA V 107 H.HA.21
Van-der-waals C-term S 411 - H.HA V 107 H.HA.21
Polar TM3 R 128 3x62 G.HN R 51 G.HN.51
Hydrophobic TM3 R 128 3x62 G.HN R 51 G.HN.51
Van-der-waals TM3 R 128 3x62 G.HN R 51 G.HN.51
Hydrophobic ICL3 A 210 - G.H5 L 371 G.H5.16
Van-der-waals ICL3 A 210 - G.H5 L 371 G.H5.16
Hydrophobic ICL3 P 202 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL3 P 202 - G.hns1 R 55 G.hns1.02
Hydrophobic C-term T 353 - G.H4 Q 328 G.H4.08
Van-der-waals C-term T 353 - G.H4 Q 328 G.H4.08
Hydrophobic C-term L 413 - H.hdhe F 173 H.hdhe.01
Hydrophobic ICL3 I 206 - G.S1 V 58 G.S1.02
Van-der-waals ICL3 I 206 - G.S1 V 58 G.S1.02
Hydrophobic C-term C 333 - G.H5 Q 372 G.H5.17
Hydrophobic C-term C 407 - G.s4h3 M 262 G.s4h3.09
Hydrophobic C-term H 410 - H.HB M 132 H.HB.10
Polar C-term S 411 - H.HA D 110 H.HA.24
Van-der-waals C-term S 411 - H.HA D 110 H.HA.24
Hydrophobic ICL3 I 206 - G.S1 L 57 G.S1.01
Hydrophobic ICL3 P 202 - G.H5 I 378 G.H5.23
Polar ICL3 S 203 - G.H5 N 374 G.H5.19
Hydrophobic ICL3 S 203 - G.H5 N 374 G.H5.19
Van-der-waals ICL3 S 203 - G.H5 N 374 G.H5.19
Polar C-term T 351 - G.H4 Q 328 G.H4.08
Hydrophobic C-term T 351 - G.H4 Q 328 G.H4.08
Van-der-waals C-term T 351 - G.H4 Q 328 G.H4.08
Hydrophobic C-term S 411 - H.hdhe F 173 H.hdhe.01
Ionic C-term E 412 - G.s4h3 R 265 G.s4h3.12
Polar C-term E 412 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term E 412 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term E 412 - G.s4h3 R 265 G.s4h3.12
Polar ICL1 K 54 - G.H5 Q 381 G.H5.26
Hydrophobic ICL1 K 54 - G.H5 Q 381 G.H5.26
Van-der-waals ICL1 K 54 - G.H5 Q 381 G.H5.26