GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 69.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 25.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL3 | P | 202 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL3 | P | 202 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL3 | I | 206 | - | G.S1 | V | 34 | G.S1.02 |
Van-der-waals | ICL3 | I | 206 | - | G.S1 | V | 34 | G.S1.02 |
Polar | TM5 | A | 198 | 5x62 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL3 | A | 210 | - | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | ICL3 | A | 210 | - | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | C-term | W | 335 | - | G.H5 | A | 339 | G.H5.10 |
Van-der-waals | C-term | W | 335 | - | G.H5 | A | 339 | G.H5.10 |
Hydrophobic | ICL3 | I | 206 | - | G.S1 | E | 33 | G.S1.01 |
Van-der-waals | ICL3 | I | 206 | - | G.S1 | E | 33 | G.S1.01 |
Polar | TM3 | K | 127 | 3x61 | G.h2s4 | V | 219 | G.h2s4.04 |
Polar | TM3 | Q | 119 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM3 | Q | 119 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM3 | Q | 119 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Polar | TM3 | Y | 116 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | Y | 116 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | Y | 116 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM5 | R | 199 | 5x63 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM5 | R | 199 | 5x63 | G.HN | E | 28 | G.HN.52 |
Polar | TM2 | S | 57 | 2x41 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | TM2 | S | 57 | 2x41 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | TM2 | S | 57 | 2x41 | G.H5 | F | 355 | G.H5.26 |
Polar | ICL3 | S | 203 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL3 | T | 204 | - | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM5 | R | 199 | 5x63 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM3 | R | 128 | 3x62 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | TM3 | R | 128 | 3x62 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM3 | K | 123 | 3x57 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | ICL3 | P | 202 | - | G.hns1 | A | 30 | G.hns1.01 |
Van-der-waals | ICL3 | P | 202 | - | G.hns1 | A | 30 | G.hns1.01 |
Hydrophobic | ICL3 | I | 206 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL3 | I | 206 | - | G.S3 | L | 195 | G.S3.01 |
Polar | ICL3 | P | 202 | - | G.S1 | E | 33 | G.S1.01 |
Hydrophobic | ICL3 | P | 202 | - | G.S1 | E | 33 | G.S1.01 |
Van-der-waals | ICL3 | P | 202 | - | G.S1 | E | 33 | G.S1.01 |
Hydrophobic | C-term | D | 330 | - | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | C-term | D | 330 | - | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM2 | Q | 59 | 2x43 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | TM2 | Q | 59 | 2x43 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | ICL3 | P | 202 | - | G.HN | G | 27 | G.HN.51 |
Van-der-waals | ICL3 | P | 202 | - | G.HN | G | 27 | G.HN.51 |
Polar | TM3 | Q | 119 | 3x53 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | ICL3 | P | 202 | - | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL3 | P | 202 | - | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM3 | Y | 116 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM3 | Y | 116 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM2 | Y | 58 | 2x42 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | TM2 | Y | 58 | 2x42 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM5 | R | 200 | 5x64 | G.hns1 | A | 31 | G.hns1.02 |
Polar | ICL3 | S | 203 | - | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | ICL3 | S | 203 | - | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL3 | S | 203 | - | G.H5 | N | 348 | G.H5.19 |
Polar | ICL1 | K | 54 | - | G.h4s6 | T | 317 | G.h4s6.10 |
Hydrophobic | ICL1 | K | 54 | - | G.h4s6 | T | 317 | G.h4s6.10 |
Van-der-waals | ICL1 | K | 54 | - | G.h4s6 | T | 317 | G.h4s6.10 |
Polar | TM3 | V | 120 | 3x54 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM3 | V | 120 | 3x54 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM3 | V | 120 | 3x54 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM3 | F | 117 | 3x51 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM5 | R | 200 | 5x64 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM5 | R | 200 | 5x64 | G.HN | E | 28 | G.HN.52 |
Ionic | TM3 | K | 123 | 3x57 | G.H5 | D | 351 | G.H5.22 |
Polar | TM3 | K | 123 | 3x57 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | TM3 | K | 123 | 3x57 | G.H5 | D | 351 | G.H5.22 |
Van-der-waals | TM3 | K | 123 | 3x57 | G.H5 | D | 351 | G.H5.22 |
Polar | ICL3 | P | 202 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL3 | P | 202 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL3 | P | 202 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM5 | R | 200 | 5x64 | G.HN | G | 27 | G.HN.51 |
Hydrophobic | ICL3 | I | 206 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL3 | I | 206 | - | G.hns1 | R | 32 | G.hns1.03 |
Aromatic | C-term | W | 335 | - | G.H5 | F | 335 | G.H5.06 |
Hydrophobic | C-term | W | 335 | - | G.H5 | F | 335 | G.H5.06 |
Van-der-waals | C-term | W | 335 | - | G.H5 | F | 335 | G.H5.06 |
Hydrophobic | ICL3 | T | 204 | - | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | ICL3 | T | 204 | - | G.H5 | C | 352 | G.H5.23 |
Polar | TM3 | K | 127 | 3x61 | G.h2s4 | G | 218 | G.h2s4.03 |
Van-der-waals | TM3 | K | 127 | 3x61 | G.h2s4 | G | 218 | G.h2s4.03 |
Polar | C-term | C | 333 | - | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | C-term | C | 333 | - | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM3 | Y | 116 | 3x50 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | TM3 | Y | 116 | 3x50 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | ICL3 | Y | 207 | - | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | ICL3 | Y | 207 | - | G.H5 | I | 345 | G.H5.16 |
Polar | TM3 | R | 128 | 3x62 | G.hns1 | A | 30 | G.hns1.01 |
Hydrophobic | TM3 | R | 128 | 3x62 | G.hns1 | A | 30 | G.hns1.01 |
Van-der-waals | TM3 | R | 128 | 3x62 | G.hns1 | A | 30 | G.hns1.01 |
Hydrophobic | C-term | G | 326 | - | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL3 | E | 209 | - | G.s2s3 | D | 194 | G.s2s3.02 |
Van-der-waals | ICL3 | E | 209 | - | G.s2s3 | D | 194 | G.s2s3.02 |
Hydrophobic | TM3 | R | 128 | 3x62 | G.HN | G | 27 | G.HN.51 |
Van-der-waals | TM3 | R | 128 | 3x62 | G.HN | G | 27 | G.HN.51 |
Ionic | ICL3 | E | 209 | - | G.hns1 | R | 32 | G.hns1.03 |
Polar | ICL3 | E | 209 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL3 | E | 209 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL3 | E | 209 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | C-term | D | 330 | - | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | C-term | D | 330 | - | G.H5 | F | 355 | G.H5.26 |
Ionic | TM3 | K | 123 | 3x57 | G.h3s5 | D | 262 | G.h3s5.02 |
Polar | TM3 | K | 123 | 3x57 | G.h3s5 | D | 262 | G.h3s5.02 |
Polar | ICL3 | S | 205 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL3 | S | 205 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL3 | S | 205 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL3 | P | 202 | - | G.HN | K | 29 | G.HN.53 |
Van-der-waals | ICL3 | P | 202 | - | G.HN | K | 29 | G.HN.53 |
Hydrophobic | TM5 | A | 201 | 5x65 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | TM5 | A | 201 | 5x65 | G.hns1 | A | 31 | G.hns1.02 |
Polar | ICL3 | A | 210 | - | G.s2s3 | K | 193 | G.s2s3.01 |
Hydrophobic | ICL3 | A | 210 | - | G.s2s3 | K | 193 | G.s2s3.01 |
Van-der-waals | ICL3 | A | 210 | - | G.s2s3 | K | 193 | G.s2s3.01 |
Hydrophobic | C-term | H | 327 | - | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | C-term | H | 327 | - | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL3 | Y | 207 | - | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | ICL3 | Y | 207 | - | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM6 | V | 215 | 6x30 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL3 | Y | 207 | - | G.H5 | L | 354 | G.H5.25 |
Polar | TM3 | R | 128 | 3x62 | G.HN | D | 26 | G.HN.50 |
Van-der-waals | TM3 | R | 128 | 3x62 | G.HN | D | 26 | G.HN.50 |
Hydrophobic | ICL3 | A | 210 | - | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | ICL1 | H | 53 | - | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | ICL1 | H | 53 | - | G.H5 | F | 355 | G.H5.26 |