Gs - GPR137 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 70.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL1 K 54 - G.s2s3 K 216 G.s2s3.02
Hydrophobic ICL1 K 54 - G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL1 K 54 - G.s2s3 K 216 G.s2s3.02
Polar TM1 Q 44 1x53 G.H5 E 392 G.H5.24
Van-der-waals TM1 Q 44 1x53 G.H5 E 392 G.H5.24
Polar ICL3 Y 207 - G.H5 R 385 G.H5.17
Aromatic ICL3 Y 207 - G.H5 R 385 G.H5.17
Hydrophobic ICL3 Y 207 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 Y 207 - G.H5 R 385 G.H5.17
Polar TM1 L 49 1x58 G.HN Q 35 G.HN.52
Hydrophobic TM1 L 49 1x58 G.HN Q 35 G.HN.52
Van-der-waals TM1 L 49 1x58 G.HN Q 35 G.HN.52
Polar ICL1 H 53 - G.H5 H 387 G.H5.19
Aromatic ICL1 H 53 - G.H5 H 387 G.H5.19
Hydrophobic ICL1 H 53 - G.H5 H 387 G.H5.19
Van-der-waals ICL1 H 53 - G.H5 H 387 G.H5.19
Polar ICL3 S 203 - G.H5 D 378 G.H5.10
Hydrophobic ICL3 S 203 - G.H5 D 378 G.H5.10
Van-der-waals ICL3 S 203 - G.H5 D 378 G.H5.10
Polar ICL3 I 206 - G.S6 Y 360 G.S6.02
Hydrophobic ICL3 I 206 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 I 206 - G.S6 Y 360 G.S6.02
Polar ICL1 K 54 - G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL1 K 54 - G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL1 H 53 - G.H5 Y 391 G.H5.23
Van-der-waals ICL1 H 53 - G.H5 Y 391 G.H5.23
Aromatic TM1 Y 51 1x60 G.H5 Y 391 G.H5.23
Hydrophobic TM1 Y 51 1x60 G.H5 Y 391 G.H5.23
Van-der-waals TM1 Y 51 1x60 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 I 206 - G.S6 P 361 G.S6.03
Ionic TM3 K 127 3x61 G.H5 D 381 G.H5.13
Polar TM3 K 127 3x61 G.H5 D 381 G.H5.13
Van-der-waals TM3 K 127 3x61 G.H5 D 381 G.H5.13
Hydrophobic ICL1 H 53 - G.H5 L 388 G.H5.20
Van-der-waals ICL1 H 53 - G.H5 L 388 G.H5.20
Polar ICL3 A 210 - G.H5 R 389 G.H5.21
Hydrophobic ICL3 A 210 - G.H5 R 389 G.H5.21
Van-der-waals ICL3 A 210 - G.H5 R 389 G.H5.21
Polar TM1 Y 51 1x60 G.hns1 R 38 G.hns1.02
Aromatic TM1 Y 51 1x60 G.hns1 R 38 G.hns1.02
Hydrophobic TM1 Y 51 1x60 G.hns1 R 38 G.hns1.02
Van-der-waals TM1 Y 51 1x60 G.hns1 R 38 G.hns1.02
Hydrophobic C-term H 327 - G.H5 L 394 G.H5.26
Van-der-waals C-term H 327 - G.H5 L 394 G.H5.26
Polar TM2 Q 59 2x43 G.H5 L 393 G.H5.25
Hydrophobic TM2 Q 59 2x43 G.H5 L 393 G.H5.25
Van-der-waals TM2 Q 59 2x43 G.H5 L 393 G.H5.25
Polar ICL1 G 52 - G.HN Q 35 G.HN.52
Hydrophobic ICL1 G 52 - G.HN Q 35 G.HN.52
Van-der-waals ICL1 G 52 - G.HN Q 35 G.HN.52
Polar C-term C 333 - G.H5 E 392 G.H5.24
Hydrophobic C-term C 333 - G.H5 E 392 G.H5.24
Van-der-waals ICL3 G 212 - G.H5 R 389 G.H5.21
Hydrophobic ICL3 A 210 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 A 210 - G.S6 Y 360 G.S6.02
Polar TM1 L 50 1x59 G.hns1 R 38 G.hns1.02
Hydrophobic TM1 L 50 1x59 G.hns1 R 38 G.hns1.02
Van-der-waals TM1 L 50 1x59 G.hns1 R 38 G.hns1.02
Polar ICL1 R 55 - G.HN Q 35 G.HN.52
Van-der-waals ICL1 R 55 - G.HN Q 35 G.HN.52
Polar ICL3 G 212 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 G 212 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 G 212 - G.h4s6 Y 358 G.h4s6.20
Polar TM3 K 127 3x61 G.H5 N 377 G.H5.09
Van-der-waals TM3 K 127 3x61 G.H5 N 377 G.H5.09
Polar C-term C 328 - G.H5 L 394 G.H5.26
Hydrophobic C-term C 328 - G.H5 L 394 G.H5.26
Van-der-waals C-term C 328 - G.H5 L 394 G.H5.26
Polar ICL3 S 203 - G.H5 R 385 G.H5.17
Hydrophobic TM3 Y 116 3x50 G.H5 L 394 G.H5.26
Hydrophobic TM1 V 48 1x57 G.H5 L 393 G.H5.25
Van-der-waals TM1 V 48 1x57 G.H5 L 393 G.H5.25
Hydrophobic ICL1 G 52 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL1 G 52 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL1 K 54 - G.S3 V 217 G.S3.01
Van-der-waals ICL1 K 54 - G.S3 V 217 G.S3.01
Ionic C-term D 330 - G.H5 R 389 G.H5.21
Polar C-term D 330 - G.H5 R 389 G.H5.21
Hydrophobic C-term D 330 - G.H5 R 389 G.H5.21
Van-der-waals C-term D 330 - G.H5 R 389 G.H5.21
Hydrophobic TM1 L 50 1x59 G.HN K 34 G.HN.51
Van-der-waals TM1 L 50 1x59 G.HN K 34 G.HN.51
Hydrophobic ICL3 A 210 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 A 210 - G.h4s6 Y 358 G.h4s6.20
Polar TM1 L 47 1x56 G.hns1 R 38 G.hns1.02
Hydrophobic ICL3 Y 207 - G.S6 Y 360 G.S6.02
Hydrophobic ICL3 K 211 - G.H5 L 394 G.H5.26
Van-der-waals ICL3 K 211 - G.H5 L 394 G.H5.26
Hydrophobic TM1 L 47 1x56 G.H5 L 393 G.H5.25
Ionic TM3 K 123 3x57 G.H5 D 381 G.H5.13
Polar TM3 K 123 3x57 G.H5 D 381 G.H5.13
Hydrophobic TM3 K 123 3x57 G.H5 D 381 G.H5.13
Van-der-waals TM3 K 123 3x57 G.H5 D 381 G.H5.13
Ionic TM3 K 127 3x61 G.H5 D 378 G.H5.10
Polar TM3 K 127 3x61 G.H5 D 378 G.H5.10
Van-der-waals TM3 K 127 3x61 G.H5 D 378 G.H5.10
Hydrophobic ICL3 Y 207 - G.H5 L 394 G.H5.26
Van-der-waals ICL3 Y 207 - G.H5 L 394 G.H5.26
Polar ICL3 E 209 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 E 209 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 E 209 - G.h4s6 Y 358 G.h4s6.20
Polar ICL3 K 211 - G.H5 R 389 G.H5.21
Hydrophobic ICL3 K 211 - G.H5 R 389 G.H5.21
Van-der-waals ICL3 K 211 - G.H5 R 389 G.H5.21
Hydrophobic ICL1 H 53 - G.H5 L 393 G.H5.25
Van-der-waals ICL1 H 53 - G.H5 L 393 G.H5.25
Polar TM1 L 50 1x59 G.HN Q 35 G.HN.52
Hydrophobic TM1 L 50 1x59 G.HN Q 35 G.HN.52
Van-der-waals TM1 L 50 1x59 G.HN Q 35 G.HN.52
Hydrophobic ICL3 I 206 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 I 206 - G.S6 C 359 G.S6.01
Hydrophobic TM1 Y 51 1x60 G.HN Q 35 G.HN.52
Van-der-waals TM1 Y 51 1x60 G.HN Q 35 G.HN.52
Polar TM1 Y 51 1x60 G.hns1 A 39 G.hns1.03
Hydrophobic TM1 Y 51 1x60 G.hns1 A 39 G.hns1.03
Van-der-waals TM1 Y 51 1x60 G.hns1 A 39 G.hns1.03