GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 72.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 22.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | L | 896 | - | G.H3 | T | 279 | G.H3.11 |
Van-der-waals | C-term | L | 896 | - | G.H3 | T | 279 | G.H3.11 |
Hydrophobic | C-term | E | 794 | - | G.HN | I | 43 | G.HN.43 |
Van-der-waals | C-term | E | 794 | - | G.HN | I | 43 | G.HN.43 |
Polar | C-term | S | 939 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | C-term | S | 939 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | S | 939 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | TM4 | K | 593 | 4x28 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM4 | K | 593 | 4x28 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | ICL2 | K | 589 | - | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | C-term | L | 791 | - | G.HN | E | 50 | G.HN.50 |
Hydrophobic | ICL2 | K | 589 | - | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | ICL2 | K | 589 | - | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | ICL2 | K | 588 | - | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | K | 588 | - | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | C-term | I | 802 | - | G.HN | S | 40 | G.HN.40 |
Hydrophobic | C-term | N | 795 | - | G.HN | I | 43 | G.HN.43 |
Van-der-waals | C-term | N | 795 | - | G.HN | I | 43 | G.HN.43 |
Hydrophobic | ICL1 | M | 514 | 12x52 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | ICL1 | M | 514 | 12x52 | G.H5 | M | 379 | G.H5.24 |
Polar | ICL2 | K | 589 | - | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | C-term | L | 899 | - | G.H2 | R | 235 | G.H2.04 |
Van-der-waals | C-term | L | 899 | - | G.H2 | R | 235 | G.H2.04 |
Hydrophobic | ICL2 | M | 587 | - | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | M | 587 | - | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | C-term | L | 899 | - | G.H2 | W | 238 | G.H2.07 |
Hydrophobic | ICL2 | M | 587 | - | G.S3 | F | 223 | G.S3.03 |
Van-der-waals | ICL2 | M | 587 | - | G.S3 | F | 223 | G.S3.03 |
Hydrophobic | TM3 | R | 577 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | R | 577 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | C-term | N | 795 | - | G.HN | L | 47 | G.HN.47 |
Hydrophobic | TM3 | I | 581 | 3x57 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM3 | I | 581 | 3x57 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | C-term | L | 896 | - | G.H3 | N | 283 | G.H3.15 |
Van-der-waals | C-term | L | 896 | - | G.H3 | N | 283 | G.H3.15 |
Polar | C-term | L | 899 | - | G.H2 | Q | 236 | G.H2.05 |
Hydrophobic | C-term | L | 899 | - | G.H2 | Q | 236 | G.H2.05 |
Van-der-waals | C-term | L | 899 | - | G.H2 | Q | 236 | G.H2.05 |
Hydrophobic | C-term | L | 788 | - | G.HN | R | 51 | G.HN.51 |
Van-der-waals | C-term | L | 788 | - | G.HN | R | 51 | G.HN.51 |
Polar | H8 | R | 759 | 8x54 | G.h4s6 | R | 342 | G.h4s6.11 |
Hydrophobic | H8 | R | 759 | 8x54 | G.h4s6 | R | 342 | G.h4s6.11 |
Van-der-waals | H8 | R | 759 | 8x54 | G.h4s6 | R | 342 | G.h4s6.11 |
Hydrophobic | C-term | L | 896 | - | G.H3 | I | 280 | G.H3.12 |
Aromatic | C-term | R | 891 | - | G.H2 | F | 239 | G.H2.08 |
Hydrophobic | C-term | R | 891 | - | G.H2 | F | 239 | G.H2.08 |
Van-der-waals | C-term | R | 891 | - | G.H2 | F | 239 | G.H2.08 |
Van-der-waals | ICL1 | K | 513 | 12x51 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | C-term | I | 802 | - | G.HN | R | 37 | G.HN.37 |
Van-der-waals | C-term | I | 802 | - | G.HN | R | 37 | G.HN.37 |
Hydrophobic | ICL2 | V | 585 | - | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | ICL2 | V | 585 | - | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | ICL2 | M | 587 | - | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | M | 587 | - | G.H5 | I | 370 | G.H5.15 |
Polar | TM4 | D | 594 | 4x29 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM4 | D | 594 | 4x29 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | C-term | L | 896 | - | G.h2s4 | F | 242 | G.h2s4.01 |
Hydrophobic | C-term | I | 898 | - | G.H3 | I | 276 | G.H3.08 |
Hydrophobic | ICL3 | I | 683 | - | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | ICL3 | I | 683 | - | G.H5 | L | 371 | G.H5.16 |
Polar | C-term | R | 891 | - | G.H2 | Q | 240 | G.H2.09 |
Hydrophobic | C-term | R | 891 | - | G.H2 | Q | 240 | G.H2.09 |
Van-der-waals | C-term | R | 891 | - | G.H2 | Q | 240 | G.H2.09 |
Hydrophobic | C-term | A | 783 | - | G.h2s4 | D | 243 | G.h2s4.02 |
Van-der-waals | C-term | A | 783 | - | G.h2s4 | D | 243 | G.h2s4.02 |
Hydrophobic | C-term | I | 898 | - | G.H3 | T | 279 | G.H3.11 |
Van-der-waals | C-term | I | 898 | - | G.H3 | T | 279 | G.H3.11 |
Hydrophobic | ICL3 | A | 685 | - | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | C-term | Y | 903 | - | G.s4h3 | E | 263 | G.s4h3.10 |
Van-der-waals | C-term | Y | 903 | - | G.s4h3 | E | 263 | G.s4h3.10 |
Hydrophobic | C-term | Y | 903 | - | G.s4h3 | D | 264 | G.s4h3.11 |
Polar | C-term | Y | 903 | - | G.s4h3 | D | 264 | G.s4h3.11 |
Van-der-waals | C-term | Y | 903 | - | G.s4h3 | D | 264 | G.s4h3.11 |
Hydrophobic | ICL2 | M | 587 | - | G.H5 | V | 366 | G.H5.11 |
Van-der-waals | ICL2 | M | 587 | - | G.H5 | V | 366 | G.H5.11 |
Polar | C-term | N | 795 | - | G.HN | D | 44 | G.HN.44 |
Hydrophobic | C-term | N | 795 | - | G.HN | D | 44 | G.HN.44 |
Van-der-waals | C-term | N | 795 | - | G.HN | D | 44 | G.HN.44 |
Hydrophobic | H8 | F | 760 | 8x55 | G.h4s6 | P | 345 | G.h4s6.20 |
Van-der-waals | H8 | F | 760 | 8x55 | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | H8 | R | 759 | 8x54 | G.h4s6 | S | 343 | G.h4s6.12 |
Van-der-waals | H8 | R | 759 | 8x54 | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | C-term | L | 894 | - | G.H3 | L | 285 | G.H3.17 |
Van-der-waals | C-term | L | 894 | - | G.H3 | L | 285 | G.H3.17 |
Hydrophobic | C-term | L | 805 | - | G.HN | E | 33 | G.HN.33 |
Hydrophobic | C-term | L | 798 | - | G.HN | I | 43 | G.HN.43 |
Van-der-waals | C-term | L | 798 | - | G.HN | I | 43 | G.HN.43 |
Hydrophobic | ICL2 | V | 585 | - | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | C-term | L | 809 | - | G.HN | E | 33 | G.HN.33 |
Van-der-waals | C-term | L | 809 | - | G.HN | E | 33 | G.HN.33 |
Hydrophobic | ICL2 | K | 588 | - | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | K | 588 | - | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | C-term | L | 791 | - | G.HN | L | 47 | G.HN.47 |
Van-der-waals | C-term | L | 791 | - | G.HN | L | 47 | G.HN.47 |
Hydrophobic | TM3 | I | 581 | 3x57 | G.H5 | N | 374 | G.H5.19 |
Polar | C-term | N | 883 | - | G.H2 | Q | 240 | G.H2.09 |
Ionic | ICL2 | K | 589 | - | G.H5 | E | 373 | G.H5.18 |
Polar | ICL2 | K | 589 | - | G.H5 | E | 373 | G.H5.18 |
Hydrophobic | ICL2 | K | 589 | - | G.H5 | E | 373 | G.H5.18 |
Van-der-waals | ICL2 | K | 589 | - | G.H5 | E | 373 | G.H5.18 |
Hydrophobic | C-term | L | 791 | - | G.HN | I | 43 | G.HN.43 |
Van-der-waals | C-term | L | 791 | - | G.HN | I | 43 | G.HN.43 |
Hydrophobic | ICL3 | I | 683 | - | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | ICL3 | I | 683 | - | G.H5 | L | 375 | G.H5.20 |
Polar | C-term | S | 939 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | C-term | L | 798 | - | G.HN | S | 40 | G.HN.40 |
Ionic | C-term | D | 806 | - | G.HN | R | 37 | G.HN.37 |
Polar | C-term | D | 806 | - | G.HN | R | 37 | G.HN.37 |
Hydrophobic | C-term | D | 806 | - | G.HN | R | 37 | G.HN.37 |
Van-der-waals | C-term | D | 806 | - | G.HN | R | 37 | G.HN.37 |
Hydrophobic | C-term | I | 882 | - | G.S2 | I | 211 | G.S2.01 |
Polar | C-term | Y | 903 | - | G.H2 | R | 232 | G.H2.01 |
Hydrophobic | C-term | Y | 903 | - | G.H2 | R | 232 | G.H2.01 |
Van-der-waals | C-term | Y | 903 | - | G.H2 | R | 232 | G.H2.01 |
Polar | C-term | S | 939 | - | H.HA | D | 110 | H.HA.24 |
Hydrophobic | C-term | L | 798 | - | G.HN | R | 39 | G.HN.39 |
Polar | C-term | N | 795 | - | G.HN | S | 40 | G.HN.40 |
Van-der-waals | C-term | N | 795 | - | G.HN | S | 40 | G.HN.40 |
Hydrophobic | ICL2 | I | 591 | - | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | ICL2 | I | 591 | - | G.H5 | D | 377 | G.H5.22 |
Ionic | C-term | E | 769 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Polar | H8 | F | 760 | 8x55 | G.h4s6 | S | 343 | G.h4s6.12 |
Ionic | C-term | R | 799 | - | G.HN | D | 44 | G.HN.44 |
Polar | C-term | R | 799 | - | G.HN | D | 44 | G.HN.44 |
Van-der-waals | C-term | R | 799 | - | G.HN | D | 44 | G.HN.44 |
Polar | ICL2 | K | 588 | - | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | C-term | L | 798 | - | G.HN | A | 36 | G.HN.36 |
Hydrophobic | C-term | I | 882 | - | G.H2 | Q | 240 | G.H2.09 |
Van-der-waals | C-term | I | 882 | - | G.H2 | Q | 240 | G.H2.09 |
Hydrophobic | ICL2 | M | 587 | - | G.S1 | V | 58 | G.S1.02 |
Van-der-waals | ICL2 | M | 587 | - | G.S1 | V | 58 | G.S1.02 |
Polar | ICL1 | K | 513 | 12x51 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL1 | K | 513 | 12x51 | G.H5 | L | 380 | G.H5.25 |
Polar | C-term | Q | 792 | - | G.HN | R | 51 | G.HN.51 |
Hydrophobic | C-term | Q | 792 | - | G.HN | R | 51 | G.HN.51 |
Van-der-waals | C-term | Q | 792 | - | G.HN | R | 51 | G.HN.51 |
Hydrophobic | C-term | I | 802 | - | G.HN | A | 36 | G.HN.36 |
Hydrophobic | ICL1 | K | 513 | 12x51 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | ICL1 | K | 513 | 12x51 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | C-term | V | 780 | - | G.H3 | L | 285 | G.H3.17 |
Van-der-waals | C-term | V | 780 | - | G.H3 | L | 285 | G.H3.17 |
Hydrophobic | C-term | L | 941 | - | H.HA | D | 110 | H.HA.24 |
Polar | ICL2 | I | 591 | - | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | C-term | L | 791 | - | G.HN | L | 46 | G.HN.46 |
Hydrophobic | TM3 | I | 581 | 3x57 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | I | 581 | 3x57 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | C-term | I | 898 | - | G.H3 | N | 275 | G.H3.07 |
Hydrophobic | ICL2 | K | 586 | - | G.S3 | I | 221 | G.S3.01 |
Ionic | C-term | R | 787 | - | G.HN | E | 50 | G.HN.50 |
Polar | C-term | R | 787 | - | G.HN | E | 50 | G.HN.50 |
Hydrophobic | C-term | R | 787 | - | G.HN | E | 50 | G.HN.50 |
Van-der-waals | C-term | R | 787 | - | G.HN | E | 50 | G.HN.50 |
Hydrophobic | ICL3 | A | 685 | - | G.H5 | M | 379 | G.H5.24 |
Polar | ICL2 | K | 590 | - | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | ICL2 | K | 590 | - | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | ICL2 | K | 590 | - | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | C-term | Q | 792 | - | G.HN | L | 47 | G.HN.47 |
Hydrophobic | C-term | L | 788 | - | G.HN | L | 47 | G.HN.47 |
Van-der-waals | C-term | L | 788 | - | G.HN | L | 47 | G.HN.47 |
Hydrophobic | C-term | V | 777 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | V | 777 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | ICL3 | L | 686 | - | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | ICL3 | L | 686 | - | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | C-term | S | 784 | - | G.h2s4 | D | 243 | G.h2s4.02 |
Hydrophobic | ICL1 | K | 510 | 12x48 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ICL2 | M | 587 | - | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | M | 587 | - | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | TM3 | F | 582 | 3x58 | G.H5 | L | 371 | G.H5.16 |