GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 72.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.4
PAE mean: 22.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | C-term | S | 771 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Hydrophobic | C-term | S | 771 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Van-der-waals | C-term | S | 771 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Hydrophobic | ICL1 | M | 514 | 12x52 | G.H5 | L | 381 | G.H5.26 |
Polar | H8 | N | 757 | 8x52 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | H8 | N | 757 | 8x52 | G.h4s6 | Y | 345 | G.h4s6.20 |
Van-der-waals | H8 | N | 757 | 8x52 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | TM3 | R | 577 | 3x53 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM3 | R | 577 | 3x53 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | M | 587 | - | G.H5 | R | 367 | G.H5.12 |
Van-der-waals | ICL2 | M | 587 | - | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | TM4 | K | 593 | 4x28 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | K | 589 | - | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | K | 589 | - | G.H5 | H | 374 | G.H5.19 |
Polar | ICL1 | M | 514 | 12x52 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL1 | M | 514 | 12x52 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | ICL1 | M | 514 | 12x52 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM3 | R | 577 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | C-term | T | 773 | - | G.H4 | F | 326 | G.H4.08 |
Hydrophobic | TM3 | I | 581 | 3x57 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | H8 | F | 760 | 8x55 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | H8 | F | 760 | 8x55 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | C-term | V | 777 | - | G.h4s6 | T | 337 | G.h4s6.03 |
Hydrophobic | ICL2 | M | 587 | - | G.S3 | V | 204 | G.S3.01 |
Polar | C-term | T | 773 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Hydrophobic | C-term | T | 773 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Van-der-waals | C-term | T | 773 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Ionic | ICL1 | K | 513 | 12x51 | G.H5 | E | 379 | G.H5.24 |
Polar | ICL1 | K | 513 | 12x51 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL1 | K | 513 | 12x51 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | ICL1 | K | 513 | 12x51 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL2 | I | 591 | - | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | ICL2 | I | 591 | - | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | M | 587 | - | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | M | 587 | - | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | ICL3 | A | 685 | - | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | ICL3 | A | 685 | - | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL3 | A | 685 | - | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL2 | M | 587 | - | G.H5 | C | 366 | G.H5.11 |
Van-der-waals | ICL2 | M | 587 | - | G.H5 | C | 366 | G.H5.11 |
Polar | ICL2 | M | 587 | - | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL2 | M | 587 | - | G.S1 | H | 43 | G.S1.02 |
Van-der-waals | ICL2 | M | 587 | - | G.S1 | H | 43 | G.S1.02 |
Polar | C-term | S | 784 | - | G.h4s6 | T | 339 | G.h4s6.08 |
Van-der-waals | C-term | S | 784 | - | G.h4s6 | T | 339 | G.h4s6.08 |
Polar | C-term | S | 774 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | C-term | S | 774 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | C-term | S | 774 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Polar | C-term | Q | 764 | - | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | C-term | Q | 764 | - | G.H5 | R | 367 | G.H5.12 |
Van-der-waals | C-term | Q | 764 | - | G.H5 | R | 367 | G.H5.12 |
Polar | ICL2 | K | 589 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Hydrophobic | TM3 | I | 581 | 3x57 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | C-term | L | 788 | - | G.h4s6 | K | 343 | G.h4s6.12 |
Polar | ICL2 | I | 592 | - | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | I | 592 | - | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | ICL2 | I | 592 | - | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | V | 585 | - | G.S3 | V | 204 | G.S3.01 |
Van-der-waals | ICL2 | V | 585 | - | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | ICL3 | I | 683 | - | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | ICL3 | I | 683 | - | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM3 | I | 581 | 3x57 | G.H5 | L | 375 | G.H5.20 |
Polar | C-term | S | 776 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | C-term | S | 776 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | C-term | S | 776 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | ICL2 | M | 587 | - | G.S3 | F | 206 | G.S3.03 |
Van-der-waals | ICL2 | M | 587 | - | G.S3 | F | 206 | G.S3.03 |
Hydrophobic | ICL3 | L | 686 | - | G.H5 | L | 380 | G.H5.25 |
Polar | H8 | N | 757 | 8x52 | G.h4s6 | G | 342 | G.h4s6.11 |
Van-der-waals | H8 | N | 757 | 8x52 | G.h4s6 | G | 342 | G.h4s6.11 |
Hydrophobic | ICL2 | K | 589 | - | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL1 | S | 515 | 12x53 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | I | 591 | - | G.H5 | Q | 377 | G.H5.22 |
Van-der-waals | ICL2 | I | 591 | - | G.H5 | Q | 377 | G.H5.22 |
Polar | ICL2 | K | 588 | - | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | K | 588 | - | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | K | 588 | - | G.H5 | H | 374 | G.H5.19 |
Polar | ICL2 | K | 589 | - | G.h2s4 | T | 229 | G.h2s4.05 |
Hydrophobic | ICL2 | K | 589 | - | G.h2s4 | T | 229 | G.h2s4.05 |
Van-der-waals | ICL2 | K | 589 | - | G.h2s4 | T | 229 | G.h2s4.05 |
Hydrophobic | C-term | L | 788 | - | G.h3s5 | R | 270 | G.h3s5.01 |
Van-der-waals | C-term | L | 788 | - | G.h3s5 | R | 270 | G.h3s5.01 |
Hydrophobic | C-term | L | 788 | - | G.h4s6 | D | 341 | G.h4s6.10 |
Hydrophobic | C-term | T | 775 | - | G.H4 | L | 333 | G.H4.16 |
Van-der-waals | C-term | T | 775 | - | G.H4 | L | 333 | G.H4.16 |
Hydrophobic | ICL2 | K | 586 | - | G.s2s3 | K | 203 | G.s2s3.02 |
Hydrophobic | C-term | Q | 889 | - | G.HN | R | 36 | G.HN.51 |
Van-der-waals | C-term | Q | 889 | - | G.HN | R | 36 | G.HN.51 |
Polar | C-term | K | 772 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Hydrophobic | C-term | K | 772 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Van-der-waals | C-term | K | 772 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Hydrophobic | ICL2 | I | 591 | - | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM3 | I | 581 | 3x57 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | I | 581 | 3x57 | G.H5 | Y | 378 | G.H5.23 |
Aromatic | H8 | F | 760 | 8x55 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | H8 | F | 760 | 8x55 | G.H5 | R | 372 | G.H5.17 |
Polar | C-term | N | 781 | - | G.h4s6 | G | 340 | G.h4s6.09 |
Hydrophobic | C-term | N | 781 | - | G.h4s6 | G | 340 | G.h4s6.09 |
Van-der-waals | C-term | N | 781 | - | G.h4s6 | G | 340 | G.h4s6.09 |
Hydrophobic | C-term | L | 892 | - | G.HN | R | 36 | G.HN.51 |
Van-der-waals | C-term | L | 892 | - | G.HN | R | 36 | G.HN.51 |
Hydrophobic | ICL3 | A | 685 | - | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | ICL3 | A | 685 | - | G.H5 | L | 380 | G.H5.25 |
Polar | ICL2 | K | 590 | - | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | K | 590 | - | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | K | 590 | - | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL1 | K | 510 | 12x48 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | ICL1 | K | 510 | 12x48 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | H8 | F | 760 | 8x55 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | H8 | F | 760 | 8x55 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL1 | M | 514 | 12x52 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | ICL1 | M | 514 | 12x52 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL3 | L | 686 | - | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | ICL3 | L | 686 | - | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL2 | K | 586 | - | G.S3 | V | 204 | G.S3.01 |
Van-der-waals | ICL2 | K | 586 | - | G.S3 | V | 204 | G.S3.01 |
Polar | C-term | T | 775 | - | G.H4 | R | 329 | G.H4.12 |
Hydrophobic | C-term | T | 775 | - | G.H4 | R | 329 | G.H4.12 |
Van-der-waals | C-term | T | 775 | - | G.H4 | R | 329 | G.H4.12 |
Hydrophobic | ICL2 | M | 587 | - | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | M | 587 | - | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | TM3 | F | 582 | 3x58 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM3 | F | 582 | 3x58 | G.H5 | Q | 371 | G.H5.16 |
Polar | ICL2 | K | 590 | - | G.H5 | Y | 378 | G.H5.23 |
Polar | C-term | T | 775 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | C-term | T | 775 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | C-term | T | 775 | - | G.hgh4 | D | 310 | G.hgh4.13 |