GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 73.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | M | 587 | - | G.H5 | C | 379 | G.H5.11 |
Van-der-waals | ICL2 | M | 587 | - | G.H5 | C | 379 | G.H5.11 |
Polar | ICL2 | I | 592 | - | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | I | 592 | - | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL2 | I | 592 | - | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | K | 586 | - | G.s2s3 | K | 216 | G.s2s3.02 |
Polar | C-term | Q | 889 | - | G.HN | K | 34 | G.HN.51 |
Hydrophobic | C-term | Q | 889 | - | G.HN | K | 34 | G.HN.51 |
Van-der-waals | C-term | Q | 889 | - | G.HN | K | 34 | G.HN.51 |
Ionic | ICL1 | K | 513 | 12x51 | G.H5 | E | 392 | G.H5.24 |
Polar | ICL1 | K | 513 | 12x51 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL1 | K | 513 | 12x51 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | ICL1 | K | 513 | 12x51 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL3 | A | 685 | - | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | ICL3 | A | 685 | - | G.H5 | L | 388 | G.H5.20 |
Ionic | C-term | D | 806 | - | G.H3 | R | 280 | G.H3.16 |
Polar | C-term | D | 806 | - | G.H3 | R | 280 | G.H3.16 |
Van-der-waals | C-term | D | 806 | - | G.H3 | R | 280 | G.H3.16 |
Aromatic | TM3 | R | 577 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | R | 577 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | I | 581 | 3x57 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | C-term | Q | 895 | - | G.HN | L | 30 | G.HN.47 |
Van-der-waals | C-term | Q | 895 | - | G.HN | L | 30 | G.HN.47 |
Hydrophobic | ICL3 | I | 683 | - | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | ICL3 | I | 683 | - | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | H8 | F | 760 | 8x55 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | H8 | F | 760 | 8x55 | G.H5 | L | 394 | G.H5.26 |
Polar | ICL2 | K | 589 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Polar | ICL2 | I | 591 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | I | 591 | - | G.H5 | H | 387 | G.H5.19 |
Polar | ICL1 | K | 510 | 12x48 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL1 | K | 510 | 12x48 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | ICL1 | K | 510 | 12x48 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | M | 587 | - | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | ICL2 | M | 587 | - | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | C-term | L | 892 | - | G.HN | K | 34 | G.HN.51 |
Hydrophobic | ICL2 | K | 589 | - | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | TM3 | F | 582 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | F | 582 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL1 | M | 514 | 12x52 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | ICL1 | M | 514 | 12x52 | G.H5 | L | 393 | G.H5.25 |
Polar | ICL2 | K | 589 | - | G.h2s4 | T | 242 | G.h2s4.05 |
Hydrophobic | ICL2 | K | 589 | - | G.h2s4 | T | 242 | G.h2s4.05 |
Van-der-waals | ICL2 | K | 589 | - | G.h2s4 | T | 242 | G.h2s4.05 |
Hydrophobic | ICL2 | I | 591 | - | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | ICL2 | I | 591 | - | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | ICL2 | I | 591 | - | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL2 | I | 591 | - | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | H8 | N | 757 | 8x52 | G.h4s6 | G | 355 | G.h4s6.11 |
Van-der-waals | H8 | N | 757 | 8x52 | G.h4s6 | G | 355 | G.h4s6.11 |
Polar | ICL1 | M | 514 | 12x52 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL1 | M | 514 | 12x52 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | ICL1 | M | 514 | 12x52 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM3 | I | 581 | 3x57 | G.H5 | Q | 384 | G.H5.16 |
Polar | ICL2 | M | 587 | - | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | M | 587 | - | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | M | 587 | - | G.S1 | H | 41 | G.S1.02 |
Polar | ICL2 | K | 589 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL3 | L | 686 | - | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | ICL3 | L | 686 | - | G.H5 | L | 388 | G.H5.20 |
Polar | ICL2 | K | 590 | - | G.H5 | Y | 391 | G.H5.23 |
Polar | ICL2 | K | 589 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | K | 589 | - | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | K | 589 | - | G.H5 | H | 387 | G.H5.19 |
Polar | H8 | N | 757 | 8x52 | G.h4s6 | D | 354 | G.h4s6.10 |
Van-der-waals | H8 | N | 757 | 8x52 | G.h4s6 | D | 354 | G.h4s6.10 |
Polar | H8 | N | 757 | 8x52 | G.h4s6 | G | 353 | G.h4s6.09 |
Hydrophobic | ICL1 | S | 515 | 12x53 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM3 | R | 577 | 3x53 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | V | 585 | - | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | ICL3 | A | 685 | - | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | ICL3 | A | 685 | - | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | K | 589 | - | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL3 | A | 685 | - | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | ICL3 | A | 685 | - | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | M | 587 | - | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | M | 587 | - | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL1 | M | 514 | 12x52 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | ICL1 | M | 514 | 12x52 | G.H5 | L | 394 | G.H5.26 |
Polar | ICL2 | K | 588 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | K | 588 | - | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | K | 588 | - | G.H5 | H | 387 | G.H5.19 |
Polar | ICL2 | K | 590 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | K | 590 | - | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | K | 590 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | C-term | L | 892 | - | G.hns1 | Y | 37 | G.hns1.01 |
Van-der-waals | C-term | L | 892 | - | G.hns1 | Y | 37 | G.hns1.01 |
Hydrophobic | ICL2 | M | 587 | - | G.S3 | F | 219 | G.S3.03 |
Van-der-waals | ICL2 | M | 587 | - | G.S3 | F | 219 | G.S3.03 |
Polar | C-term | Q | 889 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | C-term | Q | 889 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | C-term | L | 892 | - | G.hns1 | R | 38 | G.hns1.02 |
Ionic | C-term | R | 799 | - | G.h4s6 | D | 354 | G.h4s6.10 |
Polar | C-term | R | 799 | - | G.h4s6 | D | 354 | G.h4s6.10 |
Van-der-waals | C-term | R | 799 | - | G.h4s6 | D | 354 | G.h4s6.10 |
Aromatic | H8 | F | 760 | 8x55 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | H8 | F | 760 | 8x55 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | H8 | F | 760 | 8x55 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | ICL2 | K | 586 | - | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | K | 586 | - | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | TM3 | I | 581 | 3x57 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | I | 581 | 3x57 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | M | 587 | - | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | ICL3 | L | 686 | - | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | ICL3 | L | 686 | - | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | C-term | L | 834 | - | G.H2 | I | 235 | G.H2.08 |
Hydrophobic | ICL2 | M | 587 | - | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | M | 587 | - | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | C-term | L | 838 | - | G.H2 | R | 231 | G.H2.04 |
Hydrophobic | TM4 | K | 593 | 4x28 | G.H5 | Y | 391 | G.H5.23 |