Ggust - GABAB2 complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 72.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 25.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 I 683 - G.H5 L 348 G.H5.20
Van-der-waals ICL3 I 683 - G.H5 L 348 G.H5.20
Hydrophobic C-term I 898 - G.H3 H 256 G.H3.15
Hydrophobic ICL3 L 686 - G.H5 L 353 G.H5.25
Van-der-waals ICL3 L 686 - G.H5 L 353 G.H5.25
Polar C-term L 894 - G.H2 K 209 G.H2.05
Hydrophobic C-term L 894 - G.H2 K 209 G.H2.05
Van-der-waals C-term L 894 - G.H2 K 209 G.H2.05
Polar ICL2 K 589 - G.h2s4 T 219 G.h2s4.05
Hydrophobic ICL2 K 589 - G.h2s4 T 219 G.h2s4.05
Van-der-waals ICL2 K 589 - G.h2s4 T 219 G.h2s4.05
Hydrophobic ICL2 I 591 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 I 591 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 I 591 - G.h3s5 T 261 G.h3s5.02
Van-der-waals ICL2 I 591 - G.h3s5 T 261 G.h3s5.02
Hydrophobic C-term L 899 - G.H2 R 208 G.H2.04
Van-der-waals C-term L 899 - G.H2 R 208 G.H2.04
Polar C-term E 811 - G.H3 Y 258 G.H3.17
Hydrophobic ICL3 P 684 - G.H5 L 348 G.H5.20
Polar C-term K 807 - G.H3 K 257 G.H3.16
Hydrophobic C-term K 807 - G.H3 K 257 G.H3.16
Van-der-waals C-term K 807 - G.H3 K 257 G.H3.16
Ionic ICL2 K 588 - G.h2s4 E 216 G.h2s4.02
Polar ICL2 I 592 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 I 592 - G.H5 D 350 G.H5.22
Polar TM2 S 516 2x35 G.H5 G 352 G.H5.24
Van-der-waals TM2 S 516 2x35 G.H5 G 352 G.H5.24
Polar C-term I 898 - G.H3 S 252 G.H3.11
Hydrophobic C-term I 898 - G.H3 S 252 G.H3.11
Van-der-waals C-term I 898 - G.H3 S 252 G.H3.11
Hydrophobic C-term L 896 - G.H2 R 208 G.H2.04
Van-der-waals C-term L 896 - G.H2 R 208 G.H2.04
Hydrophobic C-term I 898 - G.h2s4 F 215 G.h2s4.01
Ionic C-term D 881 - H.HA K 86 H.HA.24
Polar C-term D 881 - H.HA K 86 H.HA.24
Van-der-waals C-term D 881 - H.HA K 86 H.HA.24
Hydrophobic C-term E 810 - G.H2 I 212 G.H2.08
Hydrophobic ICL2 M 587 - G.h2s4 G 217 G.h2s4.03
Van-der-waals ICL2 M 587 - G.h2s4 G 217 G.h2s4.03
Hydrophobic C-term Q 828 - G.S2 I 185 G.S2.02
Van-der-waals C-term Q 828 - G.S2 I 185 G.S2.02
Polar TM3 R 577 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 577 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 577 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL3 A 685 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 A 685 - G.H5 F 354 G.H5.26
Hydrophobic ICL2 V 585 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 V 585 - G.hns1 A 31 G.hns1.02
Polar C-term Y 903 - G.H3 E 245 G.H3.04
Hydrophobic C-term Y 903 - G.H3 E 245 G.H3.04
Van-der-waals C-term Y 903 - G.H3 E 245 G.H3.04
Hydrophobic ICL2 V 585 - G.hns1 D 30 G.hns1.01
Van-der-waals ICL2 V 585 - G.hns1 D 30 G.hns1.01
Ionic ICL2 K 586 - G.hns1 D 30 G.hns1.01
Hydrophobic ICL2 K 586 - G.hns1 D 30 G.hns1.01
Van-der-waals ICL2 K 586 - G.hns1 D 30 G.hns1.01
Polar ICL2 K 589 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 K 589 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 K 589 - G.H5 N 347 G.H5.19
Hydrophobic ICL3 P 684 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 P 684 - G.H5 I 344 G.H5.16
Hydrophobic C-term Y 903 - G.s4h3 D 237 G.s4h3.11
Van-der-waals C-term Y 903 - G.s4h3 D 237 G.s4h3.11
Hydrophobic C-term L 896 - G.H2 W 211 G.H2.07
Polar ICL2 K 589 - G.h3s5 T 261 G.h3s5.02
Hydrophobic ICL2 K 589 - G.h3s5 T 261 G.h3s5.02
Van-der-waals ICL2 K 589 - G.h3s5 T 261 G.h3s5.02
Hydrophobic C-term I 898 - G.H3 I 253 G.H3.12
Hydrophobic TM3 R 577 3x53 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 577 3x53 G.H5 L 353 G.H5.25
Hydrophobic C-term Y 831 - H.HA E 68 H.HA.06
Van-der-waals C-term Y 831 - H.HA E 68 H.HA.06
Polar ICL1 K 513 12x51 G.H5 F 354 G.H5.26
Hydrophobic ICL1 K 513 12x51 G.H5 F 354 G.H5.26
Van-der-waals ICL1 K 513 12x51 G.H5 F 354 G.H5.26
Polar ICL2 K 589 - G.S5 S 263 G.S5.01
Hydrophobic TM3 F 582 3x58 G.hns1 R 32 G.hns1.03
Hydrophobic C-term M 800 - G.h4s6 L 312 G.h4s6.03
Hydrophobic C-term L 834 - H.HA E 68 H.HA.06
Polar TM3 R 577 3x53 G.H5 G 352 G.H5.24
Hydrophobic TM3 R 577 3x53 G.H5 G 352 G.H5.24
Van-der-waals TM3 R 577 3x53 G.H5 G 352 G.H5.24
Hydrophobic C-term L 838 - H.hbhc D 116 H.hbhc.04
Van-der-waals C-term L 838 - H.hbhc D 116 H.hbhc.04
Hydrophobic C-term L 896 - G.H2 K 209 G.H2.05
Polar ICL1 M 514 12x52 G.H5 F 354 G.H5.26
Hydrophobic ICL1 M 514 12x52 G.H5 F 354 G.H5.26
Van-der-waals ICL1 M 514 12x52 G.H5 F 354 G.H5.26
Hydrophobic C-term L 899 - G.H3 L 249 G.H3.08
Van-der-waals C-term L 899 - G.H3 L 249 G.H3.08
Ionic ICL1 K 510 12x48 G.h4s6 E 318 G.h4s6.12
Polar ICL1 K 510 12x48 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL1 K 510 12x48 G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL1 K 510 12x48 G.h4s6 E 318 G.h4s6.12
Hydrophobic C-term Y 903 - G.s4h3 L 234 G.s4h3.08
Van-der-waals C-term Y 903 - G.s4h3 L 234 G.s4h3.08
Hydrophobic C-term A 902 - G.H3 H 248 G.H3.07
Van-der-waals C-term A 902 - G.H3 H 248 G.H3.07
Polar C-term Y 903 - G.H2 R 205 G.H2.01
Aromatic C-term Y 903 - G.H2 R 205 G.H2.01
Hydrophobic C-term Y 903 - G.H2 R 205 G.H2.01
Van-der-waals C-term Y 903 - G.H2 R 205 G.H2.01
Hydrophobic ICL3 A 685 - G.H5 L 353 G.H5.25
Van-der-waals ICL3 A 685 - G.H5 L 353 G.H5.25
Hydrophobic C-term S 893 - G.H2 K 209 G.H2.05
Ionic C-term E 811 - G.H3 K 257 G.H3.16
Polar C-term E 811 - G.H3 K 257 G.H3.16
Hydrophobic C-term E 811 - G.H3 K 257 G.H3.16
Van-der-waals C-term E 811 - G.H3 K 257 G.H3.16
Ionic ICL2 K 589 - G.H5 D 350 G.H5.22
Polar ICL2 K 589 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 K 589 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 K 589 - G.H5 D 350 G.H5.22
Hydrophobic C-term R 799 - G.h4s6 L 312 G.h4s6.03
Hydrophobic C-term T 803 - G.H3 N 255 G.H3.14
Polar C-term Q 764 - G.H4 E 297 G.H4.04
Van-der-waals C-term Q 764 - G.H4 E 297 G.H4.04
Hydrophobic C-term M 814 - G.H2 I 212 G.H2.08
Van-der-waals C-term M 814 - G.H2 I 212 G.H2.08
Hydrophobic C-term L 838 - H.hbhc E 115 H.hbhc.03
Polar C-term Y 825 - G.H2 H 213 G.H2.09
Hydrophobic ICL1 M 514 12x52 G.H5 L 353 G.H5.25
Van-der-waals ICL1 M 514 12x52 G.H5 L 353 G.H5.25
Hydrophobic ICL3 L 686 - G.H5 L 348 G.H5.20
Van-der-waals ICL3 L 686 - G.H5 L 348 G.H5.20
Ionic C-term E 810 - G.H3 H 256 G.H3.15
Polar C-term E 810 - G.H3 H 256 G.H3.15
Hydrophobic C-term E 810 - G.H3 H 256 G.H3.15
Van-der-waals C-term E 810 - G.H3 H 256 G.H3.15
Hydrophobic TM3 F 582 3x58 G.hns1 A 31 G.hns1.02
Van-der-waals TM3 F 582 3x58 G.hns1 A 31 G.hns1.02
Hydrophobic ICL3 A 685 - G.H5 L 348 G.H5.20
Van-der-waals ICL3 A 685 - G.H5 L 348 G.H5.20
Hydrophobic ICL2 I 592 - G.H5 G 352 G.H5.24
Hydrophobic TM3 K 583 3x59 G.HN Q 24 G.HN.48
Van-der-waals TM3 K 583 3x59 G.HN Q 24 G.HN.48
Polar C-term H 796 - G.h4s6 L 312 G.h4s6.03
Hydrophobic C-term H 796 - G.h4s6 L 312 G.h4s6.03
Van-der-waals C-term H 796 - G.h4s6 L 312 G.h4s6.03
Polar TM5 E 677 5x60 G.HN Q 24 G.HN.48
Van-der-waals TM5 E 677 5x60 G.HN Q 24 G.HN.48
Hydrophobic C-term Y 903 - G.s4h3 V 240 G.s4h3.14
Van-der-waals C-term Y 903 - G.s4h3 V 240 G.s4h3.14
Hydrophobic ICL3 I 683 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 I 683 - G.H5 I 344 G.H5.16
Hydrophobic C-term T 823 - G.H2 H 213 G.H2.09
Hydrophobic TM3 I 581 3x57 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 581 3x57 G.H5 C 351 G.H5.23
Hydrophobic C-term K 807 - G.H3 H 256 G.H3.15
Van-der-waals C-term K 807 - G.H3 H 256 G.H3.15
Polar C-term L 892 - G.H2 K 209 G.H2.05
Van-der-waals C-term L 892 - G.H2 K 209 G.H2.05
Hydrophobic ICL2 M 587 - G.h2s4 E 216 G.h2s4.02
Van-der-waals ICL2 M 587 - G.h2s4 E 216 G.h2s4.02
Hydrophobic C-term L 840 - H.hbhc E 115 H.hbhc.03
Hydrophobic ICL1 K 510 12x48 G.H5 F 354 G.H5.26
Ionic TM3 K 583 3x59 G.HN E 28 G.HN.52