G13 - GAL1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 23.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar H8 E 308 8x48 G.H5 Q 373 G.H5.22
Polar H8 S 307 8x47 G.H5 L 376 G.H5.25
Hydrophobic H8 S 307 8x47 G.H5 L 376 G.H5.25
Van-der-waals H8 S 307 8x47 G.H5 L 376 G.H5.25
Polar TM6 S 241 6x29 G.H5 H 368 G.H5.17
Hydrophobic TM6 S 241 6x29 G.H5 H 368 G.H5.17
Van-der-waals TM6 S 241 6x29 G.H5 H 368 G.H5.17
Polar ICL2 S 140 34x50 G.S3 V 216 G.S3.01
Hydrophobic ICL2 S 140 34x50 G.S3 V 216 G.S3.01
Van-der-waals ICL2 S 140 34x50 G.S3 V 216 G.S3.01
Hydrophobic TM6 V 249 6x37 G.H5 M 375 G.H5.24
Van-der-waals TM6 V 249 6x37 G.H5 M 375 G.H5.24
Hydrophobic TM6 T 248 6x36 G.H5 L 376 G.H5.25
Hydrophobic ICL2 S 144 34x54 G.HN T 43 G.HN.52
Van-der-waals ICL2 S 144 34x54 G.HN T 43 G.HN.52
Hydrophobic ICL3 M 234 - G.H5 D 364 G.H5.13
Van-der-waals ICL3 M 234 - G.H5 D 364 G.H5.13
Polar TM3 H 139 3x56 G.hns1 R 47 G.hns1.03
Hydrophobic TM3 H 139 3x56 G.hns1 R 47 G.hns1.03
Van-der-waals TM3 H 139 3x56 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 S 143 34x53 G.HN T 43 G.HN.52
Van-der-waals ICL2 S 143 34x53 G.HN T 43 G.HN.52
Hydrophobic TM4 A 171 4x62 G.HN A 2 G.HN.02
Van-der-waals TM4 A 171 4x62 G.HN A 2 G.HN.02
Hydrophobic TM5 L 227 5x65 G.H5 L 371 G.H5.20
Van-der-waals TM5 L 227 5x65 G.H5 L 371 G.H5.20
Van-der-waals ICL2 S 144 34x54 G.hns1 R 47 G.hns1.03
Polar TM3 F 110 3x27 G.HN D 3 G.HN.03
Polar ICL2 S 140 34x50 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 S 140 34x50 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 S 140 34x50 G.hns1 R 47 G.hns1.03
Polar H8 N 309 8x49 G.H5 Q 373 G.H5.22
Van-der-waals ICL3 M 234 - G.H5 D 361 G.H5.10
Polar TM2 T 69 2x38 G.hns1 K 46 G.hns1.02
Hydrophobic TM6 T 248 6x36 G.H5 M 375 G.H5.24
Hydrophobic TM5 L 231 5x69 G.H5 D 364 G.H5.13
Van-der-waals TM5 L 231 5x69 G.H5 D 364 G.H5.13
Polar ICL2 R 141 34x51 G.s2s3 N 215 G.s2s3.02
Hydrophobic ICL2 R 141 34x51 G.s2s3 N 215 G.s2s3.02
Van-der-waals ICL2 R 141 34x51 G.s2s3 N 215 G.s2s3.02
Polar ICL2 R 141 34x51 G.hns1 R 47 G.hns1.03
Hydrophobic TM7 L 306 7x56 G.H5 L 376 G.H5.25
Polar TM2 S 68 2x37 G.hns1 K 46 G.hns1.02
Hydrophobic TM2 S 68 2x37 G.hns1 K 46 G.hns1.02
Van-der-waals TM2 S 68 2x37 G.hns1 K 46 G.hns1.02
Hydrophobic TM5 V 223 5x61 G.H5 M 375 G.H5.24
Hydrophobic TM4 V 148 4x38 G.HN S 39 G.HN.48
Van-der-waals TM4 V 148 4x38 G.HN S 39 G.HN.48
Polar ICL2 R 147 34x57 G.HN T 43 G.HN.52
Hydrophobic ICL2 R 147 34x57 G.HN T 43 G.HN.52
Van-der-waals ICL2 R 147 34x57 G.HN T 43 G.HN.52
Polar TM6 S 241 6x29 G.H5 K 372 G.H5.21
Hydrophobic TM6 S 241 6x29 G.H5 K 372 G.H5.21
Van-der-waals TM6 S 241 6x29 G.H5 K 372 G.H5.21
Hydrophobic TM5 K 230 5x68 G.H5 D 364 G.H5.13
Van-der-waals TM5 K 230 5x68 G.H5 D 364 G.H5.13
Polar ICL2 S 140 34x50 G.s2s3 N 215 G.s2s3.02
Hydrophobic ICL2 S 140 34x50 G.s2s3 N 215 G.s2s3.02
Van-der-waals ICL2 S 140 34x50 G.s2s3 N 215 G.s2s3.02
Ionic TM3 K 109 3x26 G.HN D 3 G.HN.03
Polar TM3 K 109 3x26 G.HN D 3 G.HN.03
Hydrophobic TM3 K 109 3x26 G.HN D 3 G.HN.03
Van-der-waals TM3 K 109 3x26 G.HN D 3 G.HN.03
Polar ICL2 S 143 34x53 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 S 143 34x53 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 S 143 34x53 G.hns1 R 47 G.hns1.03
Hydrophobic TM6 T 245 6x33 G.H5 M 375 G.H5.24
Van-der-waals TM6 T 245 6x33 G.H5 M 375 G.H5.24
Polar ICL1 P 66 - G.HN K 42 G.HN.51
Hydrophobic ICL1 P 66 - G.HN K 42 G.HN.51
Van-der-waals ICL1 P 66 - G.HN K 42 G.HN.51
Polar TM3 R 133 3x50 G.H5 M 375 G.H5.24
Hydrophobic TM3 R 133 3x50 G.H5 M 375 G.H5.24
Van-der-waals TM3 R 133 3x50 G.H5 M 375 G.H5.24
Polar TM3 A 136 3x53 G.hns1 R 47 G.hns1.03
Hydrophobic TM3 A 136 3x53 G.hns1 R 47 G.hns1.03
Van-der-waals TM3 A 136 3x53 G.hns1 R 47 G.hns1.03
Hydrophobic TM3 C 108 3x25 G.HN M 1 G.HN.01
Van-der-waals TM3 C 108 3x25 G.HN M 1 G.HN.01
Polar H8 E 308 8x48 G.H5 L 376 G.H5.25
Hydrophobic TM2 I 74 2x43 G.H5 Q 377 G.H5.26
Van-der-waals TM2 I 74 2x43 G.H5 Q 377 G.H5.26
Polar TM3 R 133 3x50 G.H5 Q 377 G.H5.26
Van-der-waals TM3 R 133 3x50 G.H5 Q 377 G.H5.26
Polar H8 K 312 8x52 G.h3s5 N 283 G.h3s5.02
Hydrophobic H8 K 312 8x52 G.h3s5 N 283 G.h3s5.02
Van-der-waals H8 K 312 8x52 G.h3s5 N 283 G.h3s5.02
Van-der-waals ICL1 K 65 - G.HN K 42 G.HN.51
Hydrophobic H8 S 307 8x47 G.H5 Q 377 G.H5.26
Polar TM3 V 135 3x52 G.hns1 R 47 G.hns1.03
Van-der-waals TM3 V 135 3x52 G.hns1 R 47 G.hns1.03
Polar TM2 T 70 2x39 G.hns1 K 46 G.hns1.02
Hydrophobic TM3 K 109 3x26 G.HN M 1 G.HN.01
Van-der-waals TM3 K 109 3x26 G.HN M 1 G.HN.01
Hydrophobic TM3 Y 113 3x30 G.HN A 2 G.HN.02
Van-der-waals TM3 Y 113 3x30 G.HN A 2 G.HN.02
Polar H8 K 312 8x52 G.h3s5 S 282 G.h3s5.01
Polar TM4 Q 174 4x65 G.HN M 1 G.HN.01
Hydrophobic TM4 Q 174 4x65 G.HN M 1 G.HN.01
Van-der-waals TM4 Q 174 4x65 G.HN M 1 G.HN.01
Hydrophobic TM4 A 171 4x62 G.HN F 4 G.HN.04
Hydrophobic ECL2 C 187 45x50 G.HN M 1 G.HN.01
Van-der-waals ECL2 C 187 45x50 G.HN M 1 G.HN.01
Hydrophobic TM6 K 244 6x32 G.H5 K 372 G.H5.21
Van-der-waals TM6 K 244 6x32 G.H5 K 372 G.H5.21
Hydrophobic TM3 F 106 3x23 G.HN L 5 G.HN.05
Hydrophobic TM3 I 137 3x54 G.H5 M 375 G.H5.24
Aromatic TM3 Y 113 3x30 G.HN F 4 G.HN.04
Hydrophobic TM3 Y 113 3x30 G.HN F 4 G.HN.04
Van-der-waals TM3 Y 113 3x30 G.HN F 4 G.HN.04
Polar TM6 K 237 6x25 G.h4s6 P 341 G.h4s6.20
Hydrophobic TM6 K 237 6x25 G.h4s6 P 341 G.h4s6.20
Van-der-waals TM6 K 237 6x25 G.h4s6 P 341 G.h4s6.20
Hydrophobic TM4 I 164 4x54 G.HN F 4 G.HN.04
Hydrophobic TM3 H 112 3x29 G.HN M 1 G.HN.01
Van-der-waals TM3 H 112 3x29 G.HN M 1 G.HN.01
Polar TM6 K 237 6x25 G.S6 Y 343 G.S6.02
Hydrophobic TM6 K 237 6x25 G.S6 Y 343 G.S6.02
Van-der-waals TM6 K 237 6x25 G.S6 Y 343 G.S6.02
Polar H8 E 308 8x48 G.h3s5 N 283 G.h3s5.02
Hydrophobic H8 E 308 8x48 G.h3s5 N 283 G.h3s5.02
Van-der-waals H8 E 308 8x48 G.h3s5 N 283 G.h3s5.02
Van-der-waals TM6 T 245 6x33 G.H5 K 372 G.H5.21
Polar TM6 K 242 6x30 G.H5 H 368 G.H5.17
Hydrophobic TM6 K 242 6x30 G.H5 H 368 G.H5.17
Van-der-waals TM6 K 242 6x30 G.H5 H 368 G.H5.17
Hydrophobic ICL2 S 144 34x54 G.HN Y 44 G.HN.53
Polar TM4 V 170 4x61 G.HN A 2 G.HN.02
Hydrophobic TM4 V 170 4x61 G.HN A 2 G.HN.02
Van-der-waals TM4 V 170 4x61 G.HN A 2 G.HN.02
Polar ICL2 S 140 34x50 G.s2s3 K 214 G.s2s3.01
Hydrophobic TM3 F 110 3x27 G.HN L 5 G.HN.05
Van-der-waals TM3 F 110 3x27 G.HN L 5 G.HN.05
Polar TM3 K 109 3x26 G.HN A 2 G.HN.02
Hydrophobic TM3 K 109 3x26 G.HN A 2 G.HN.02
Van-der-waals TM3 K 109 3x26 G.HN A 2 G.HN.02
Hydrophobic H8 N 309 8x49 G.H5 Q 377 G.H5.26
Van-der-waals H8 N 309 8x49 G.H5 Q 377 G.H5.26
Hydrophobic TM3 I 137 3x54 G.H5 L 371 G.H5.20
Van-der-waals TM3 I 137 3x54 G.H5 L 371 G.H5.20
Ionic ICL2 R 141 34x51 G.S2 E 212 G.S2.07
Polar ICL2 R 141 34x51 G.S2 E 212 G.S2.07
Hydrophobic ICL2 R 141 34x51 G.S2 E 212 G.S2.07
Van-der-waals ICL2 R 141 34x51 G.S2 E 212 G.S2.07
Hydrophobic ICL3 M 234 - G.H5 T 365 G.H5.14
Van-der-waals ICL3 M 234 - G.H5 T 365 G.H5.14
Hydrophobic TM3 F 106 3x23 G.HN D 3 G.HN.03
Polar TM4 V 170 4x61 G.HN M 1 G.HN.01
Hydrophobic TM4 V 170 4x61 G.HN M 1 G.HN.01
Van-der-waals TM4 V 170 4x61 G.HN M 1 G.HN.01
Hydrophobic TM3 I 111 3x28 G.HN M 1 G.HN.01
Hydrophobic ECL1 W 101 23x50 G.HN M 1 G.HN.01
Van-der-waals ECL1 W 101 23x50 G.HN M 1 G.HN.01
Polar TM5 K 230 5x68 G.s2s3 K 214 G.s2s3.01
Hydrophobic TM5 K 230 5x68 G.s2s3 K 214 G.s2s3.01
Van-der-waals TM5 K 230 5x68 G.s2s3 K 214 G.s2s3.01
Hydrophobic TM4 A 171 4x62 G.HN M 1 G.HN.01
Hydrophobic TM2 T 70 2x39 G.H5 Q 377 G.H5.26
Van-der-waals TM2 T 70 2x39 G.H5 Q 377 G.H5.26
Hydrophobic TM5 L 231 5x69 G.H5 H 368 G.H5.17
Polar TM6 S 238 6x26 G.H5 H 368 G.H5.17
Hydrophobic TM6 S 238 6x26 G.H5 H 368 G.H5.17
Van-der-waals TM6 S 238 6x26 G.H5 H 368 G.H5.17