Gs - GAL2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 R 134 34x54 G.S1 T 40 G.S1.01
Hydrophobic ICL2 R 134 34x54 G.S1 T 40 G.S1.01
Van-der-waals ICL2 R 134 34x54 G.S1 T 40 G.S1.01
Polar ICL2 R 134 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 R 134 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 R 134 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 P 130 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 127 3x54 G.H5 L 393 G.H5.25
Aromatic TM3 R 123 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM4 P 139 4x39 G.hns1 R 38 G.hns1.02
Hydrophobic TM6 A 230 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 A 230 6x29 G.H5 L 394 G.H5.26
Polar TM6 V 234 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 V 234 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 234 6x33 G.H5 L 393 G.H5.25
Hydrophobic H8 S 296 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 S 296 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 H 132 34x52 G.S3 V 217 G.S3.01
Van-der-waals ICL2 H 132 34x52 G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 131 34x51 G.H5 C 379 G.H5.11
Polar H8 K 297 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 297 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 297 8x48 G.H5 E 392 G.H5.24
Polar ICL2 R 134 34x54 G.S1 H 41 G.S1.02
Aromatic ICL2 R 134 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 R 134 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 R 134 34x54 G.S1 H 41 G.S1.02
Polar TM3 I 127 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 127 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 127 3x54 G.H5 Q 384 G.H5.16
Polar TM4 T 138 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM4 T 138 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM5 L 214 5x65 G.H5 L 388 G.H5.20
Polar ICL2 L 131 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 131 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 131 34x51 G.S1 H 41 G.S1.02
Polar ICL2 R 137 34x57 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 R 137 34x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 131 34x51 G.H5 R 380 G.H5.12
Polar ICL2 R 134 34x54 G.hns1 A 39 G.hns1.03
Polar ICL2 R 137 34x57 G.H5 H 387 G.H5.19
Van-der-waals ICL2 R 137 34x57 G.H5 H 387 G.H5.19
Polar TM6 K 233 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 233 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 233 6x32 G.H5 L 394 G.H5.26
Polar ICL1 V 57 12x51 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 L 131 34x51 G.S3 F 219 G.S3.03
Hydrophobic TM5 V 218 5x69 G.H5 Q 384 G.H5.16
Van-der-waals TM5 V 218 5x69 G.H5 Q 384 G.H5.16
Polar TM3 D 122 3x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 130 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 130 34x50 G.H5 I 383 G.H5.15
Hydrophobic ICL2 P 130 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 130 34x50 G.H5 R 380 G.H5.12
Hydrophobic TM6 K 233 6x32 G.H5 L 393 G.H5.25
Van-der-waals TM6 K 233 6x32 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 127 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 127 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 127 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 131 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 131 34x51 G.H5 F 376 G.H5.08
Hydrophobic TM6 I 238 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM6 V 234 6x33 G.H5 L 388 G.H5.20
Hydrophobic ICL2 H 132 34x52 G.H5 F 376 G.H5.08
Hydrophobic TM6 M 237 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 M 237 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM3 A 126 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 126 3x53 G.H5 Y 391 G.H5.23
Polar TM2 T 60 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 T 60 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 60 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 131 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 131 34x51 G.H5 I 383 G.H5.15
Polar TM3 A 126 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 126 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 126 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 131 34x51 G.S3 V 217 G.S3.01
Ionic TM6 K 233 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 233 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 233 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 233 6x32 G.H5 E 392 G.H5.24
Hydrophobic ICL2 E 135 34x55 G.hns1 A 39 G.hns1.03
Polar ICL2 H 132 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 H 132 34x52 G.s2s3 D 215 G.s2s3.01
Polar TM5 Y 213 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Y 213 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Y 213 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 214 5x65 G.H5 Q 384 G.H5.16