G13 - CCK2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 159 34x50 G.H5 K 363 G.H5.12
Hydrophobic TM6 M 334 6x36 G.H5 L 376 G.H5.25
Van-der-waals TM6 M 334 6x36 G.H5 L 376 G.H5.25
Hydrophobic TM5 L 245 5x65 G.H5 L 371 G.H5.20
Van-der-waals TM5 L 245 5x65 G.H5 L 371 G.H5.20
Hydrophobic H8 H 394 8x47 G.H5 M 375 G.H5.24
Polar TM3 A 155 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM3 A 155 3x53 G.H5 N 370 G.H5.19
Van-der-waals TM3 A 155 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM4 T 167 4x38 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 P 159 34x50 G.H5 L 367 G.H5.16
Hydrophobic ICL2 L 160 34x51 G.S1 V 49 G.S1.02
Hydrophobic ICL2 L 160 34x51 G.H5 I 366 G.H5.15
Van-der-waals ICL2 L 160 34x51 G.H5 I 366 G.H5.15
Polar H8 H 394 8x47 G.H5 L 376 G.H5.25
Hydrophobic H8 H 394 8x47 G.H5 L 376 G.H5.25
Van-der-waals H8 H 394 8x47 G.H5 L 376 G.H5.25
Hydrophobic H8 H 394 8x47 G.H5 L 374 G.H5.23
Van-der-waals H8 H 394 8x47 G.H5 L 374 G.H5.23
Polar ICL2 R 163 34x54 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 R 163 34x54 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 R 163 34x54 G.hns1 R 47 G.hns1.03
Polar ICL2 R 163 34x54 G.h2s4 T 241 G.h2s4.05
Hydrophobic ICL2 R 163 34x54 G.h2s4 T 241 G.h2s4.05
Van-der-waals ICL2 R 163 34x54 G.h2s4 T 241 G.h2s4.05
Hydrophobic ICL2 L 160 34x51 G.H5 K 363 G.H5.12
Polar ICL2 V 164 34x55 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 V 164 34x55 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 V 164 34x55 G.hns1 R 47 G.hns1.03
Hydrophobic TM2 T 89 2x39 G.H5 L 374 G.H5.23
Van-der-waals TM2 T 89 2x39 G.H5 L 374 G.H5.23
Hydrophobic TM5 L 245 5x65 G.H5 M 375 G.H5.24
Polar ICL2 R 163 34x54 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 R 163 34x54 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 R 163 34x54 G.hns1 K 46 G.hns1.02
Polar TM3 R 152 3x50 G.H5 L 374 G.H5.23
Hydrophobic TM3 R 152 3x50 G.H5 L 374 G.H5.23
Hydrophobic ICL2 P 159 34x50 G.H5 I 366 G.H5.15
Hydrophobic ICL2 V 164 34x55 G.S3 P 217 G.S3.02
Hydrophobic H8 R 396 8x49 G.H5 Q 373 G.H5.22
Polar H8 R 396 8x49 G.H5 K 372 G.H5.21
Hydrophobic H8 R 396 8x49 G.H5 K 372 G.H5.21
Van-der-waals H8 R 396 8x49 G.H5 K 372 G.H5.21
Hydrophobic TM4 T 167 4x38 G.HN T 43 G.HN.52
Van-der-waals TM4 T 167 4x38 G.HN T 43 G.HN.52
Hydrophobic ICL2 L 160 34x51 G.H5 V 362 G.H5.11
Hydrophobic ICL2 L 160 34x51 G.S3 V 216 G.S3.01
Van-der-waals ICL2 L 160 34x51 G.S3 V 216 G.S3.01
Hydrophobic TM3 I 156 3x54 G.H5 M 375 G.H5.24
Van-der-waals TM3 I 156 3x54 G.H5 M 375 G.H5.24
Hydrophobic TM7 M 393 7x56 G.H5 L 376 G.H5.25
Van-der-waals TM7 M 393 7x56 G.H5 L 376 G.H5.25
Hydrophobic H8 R 395 8x48 G.H5 Q 377 G.H5.26
Van-der-waals H8 R 395 8x48 G.H5 Q 377 G.H5.26
Hydrophobic ICL2 L 160 34x51 G.H5 F 359 G.H5.08
Van-der-waals ICL2 L 160 34x51 G.H5 F 359 G.H5.08
Hydrophobic TM3 A 155 3x53 G.H5 L 374 G.H5.23
Van-der-waals TM3 A 155 3x53 G.H5 L 374 G.H5.23
Polar H8 R 395 8x48 G.H5 L 376 G.H5.25
Hydrophobic ICL2 R 163 34x54 G.H5 I 366 G.H5.15
Van-der-waals ICL2 R 163 34x54 G.H5 I 366 G.H5.15
Hydrophobic ICL2 L 160 34x51 G.S3 F 218 G.S3.03
Hydrophobic TM3 I 156 3x54 G.H5 L 371 G.H5.20
Hydrophobic TM6 V 331 6x33 G.H5 M 375 G.H5.24
Van-der-waals TM6 V 331 6x33 G.H5 M 375 G.H5.24
Hydrophobic TM6 R 330 6x32 G.H5 L 376 G.H5.25
Hydrophobic ICL2 R 163 34x54 G.S1 V 49 G.S1.02
Hydrophobic TM3 I 156 3x54 G.H5 L 374 G.H5.23
Polar H8 R 396 8x49 G.H5 Q 377 G.H5.26
Hydrophobic H8 R 396 8x49 G.H5 Q 377 G.H5.26
Van-der-waals H8 R 396 8x49 G.H5 Q 377 G.H5.26
Polar ICL2 R 163 34x54 G.S1 L 48 G.S1.01
Hydrophobic ICL2 R 163 34x54 G.S1 L 48 G.S1.01
Van-der-waals ICL2 R 163 34x54 G.S1 L 48 G.S1.01
Hydrophobic TM3 I 156 3x54 G.H5 L 367 G.H5.16
Van-der-waals TM3 I 156 3x54 G.H5 L 367 G.H5.16
Van-der-waals TM6 A 327 6x29 G.H5 Q 377 G.H5.26
Ionic TM5 E 244 5x64 G.H5 K 363 G.H5.12
Polar TM5 E 244 5x64 G.H5 K 363 G.H5.12
Van-der-waals TM5 E 244 5x64 G.H5 K 363 G.H5.12