Gq - CCK2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 10.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar C-term S 434 - G.H2 R 210 G.H2.01
Hydrophobic C-term S 434 - G.H2 R 210 G.H2.01
Van-der-waals C-term S 434 - G.H2 R 210 G.H2.01
Polar ICL2 Q 166 34x57 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 Q 166 34x57 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 Q 166 34x57 G.H5 Y 356 G.H5.23
Polar TM3 A 155 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 155 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 155 3x53 G.H5 N 352 G.H5.19
Polar C-term L 433 - G.H2 R 213 G.H2.04
Hydrophobic C-term L 433 - G.H2 R 213 G.H2.04
Van-der-waals C-term L 433 - G.H2 R 213 G.H2.04
Hydrophobic TM3 R 152 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 152 3x50 G.H5 L 358 G.H5.25
Hydrophobic ICL2 R 163 34x54 G.S1 L 40 G.S1.02
Van-der-waals ICL2 R 163 34x54 G.S1 L 40 G.S1.02
Polar TM2 T 89 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM2 T 89 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 T 89 2x39 G.H5 Y 356 G.H5.23
Polar C-term S 429 - G.H3 Y 261 G.H3.15
Hydrophobic ICL2 L 160 34x51 G.H5 F 341 G.H5.08
Van-der-waals ICL2 L 160 34x51 G.H5 F 341 G.H5.08
Ionic ICL3 R 262 - G.H4 D 301 G.H4.03
Polar ICL3 R 262 - G.H4 D 301 G.H4.03
Hydrophobic C-term L 436 - G.H3 L 254 G.H3.08
Polar C-term Y 438 - G.H3 E 250 G.H3.04
Van-der-waals C-term Y 438 - G.H3 E 250 G.H3.04
Hydrophobic C-term L 436 - G.H3 E 250 G.H3.04
Van-der-waals TM2 L 93 2x43 G.H5 N 357 G.H5.24
Hydrophobic TM3 I 156 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 I 156 3x54 G.H5 L 349 G.H5.16
Polar H8 R 396 8x49 G.H5 K 354 G.H5.21
Hydrophobic ICL3 V 263 - G.H4 E 307 G.H4.09
Hydrophobic C-term L 433 - G.H3 L 254 G.H3.08
Van-der-waals C-term L 433 - G.H3 L 254 G.H3.08
Hydrophobic C-term I 430 - G.H2 I 217 G.H2.08
Hydrophobic TM3 E 151 3x49 G.H5 Y 356 G.H5.23
Polar TM3 R 152 3x50 G.H5 N 357 G.H5.24
Van-der-waals TM3 R 152 3x50 G.H5 N 357 G.H5.24
Polar ICL2 R 163 34x54 G.h2s4 T 224 G.h2s4.05
Polar TM2 N 90 2x40 G.H5 N 357 G.H5.24
Van-der-waals TM2 N 90 2x40 G.H5 N 357 G.H5.24
Hydrophobic C-term L 433 - G.H3 Y 261 G.H3.15
Van-der-waals C-term L 433 - G.H3 Y 261 G.H3.15
Hydrophobic TM3 A 155 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 155 3x53 G.H5 Y 356 G.H5.23
Polar C-term Y 438 - G.H3 E 249 G.H3.03
Hydrophobic TM6 M 334 6x36 G.H5 L 358 G.H5.25
Van-der-waals TM6 M 334 6x36 G.H5 L 358 G.H5.25
Polar ICL2 R 163 34x54 G.S1 E 39 G.S1.01
Ionic TM5 E 244 5x64 G.H5 K 345 G.H5.12
Polar TM5 E 244 5x64 G.H5 K 345 G.H5.12
Hydrophobic TM2 T 89 2x39 G.H5 N 357 G.H5.24
Hydrophobic ICL2 V 164 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 P 159 34x50 G.H5 K 345 G.H5.12
Hydrophobic TM2 V 88 2x38 G.H5 Y 356 G.H5.23
Ionic TM6 K 324 6x26 G.H5 D 346 G.H5.13
Polar TM6 K 324 6x26 G.H5 D 346 G.H5.13
Van-der-waals TM6 K 324 6x26 G.H5 D 346 G.H5.13
Ionic ICL3 R 262 - G.H4 E 307 G.H4.09
Hydrophobic ICL3 R 262 - G.H4 E 307 G.H4.09
Van-der-waals ICL3 R 262 - G.H4 E 307 G.H4.09
Hydrophobic TM6 V 331 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 V 331 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM3 I 156 3x54 G.H5 N 352 G.H5.19
Hydrophobic TM6 K 324 6x26 G.h4s6 I 323 G.h4s6.20
Polar C-term S 434 - G.H2 R 214 G.H2.05
Hydrophobic C-term S 434 - G.H2 R 214 G.H2.05
Hydrophobic C-term L 436 - G.H3 A 253 G.H3.07
Van-der-waals C-term L 436 - G.H3 A 253 G.H3.07
Polar ICL3 R 262 - G.H4 Q 303 G.H4.05
Hydrophobic ICL3 R 262 - G.H4 Q 303 G.H4.05
Van-der-waals ICL3 R 262 - G.H4 Q 303 G.H4.05
Polar H8 H 394 8x47 G.H5 L 358 G.H5.25
Hydrophobic H8 H 394 8x47 G.H5 L 358 G.H5.25
Polar TM3 R 152 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 152 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 152 3x50 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 L 160 34x51 G.S3 V 199 G.S3.01
Hydrophobic TM2 T 87 2x37 G.H5 E 355 G.H5.22
Van-der-waals TM2 T 87 2x37 G.H5 E 355 G.H5.22
Hydrophobic TM6 K 324 6x26 G.H5 Q 350 G.H5.17
Van-der-waals TM6 K 324 6x26 G.H5 Q 350 G.H5.17
Hydrophobic ICL2 V 164 34x55 G.hns1 R 37 G.hns1.02
Hydrophobic C-term L 433 - G.H3 I 258 G.H3.12
Hydrophobic C-term L 433 - G.H3 T 257 G.H3.11
Hydrophobic C-term Y 438 - G.s4h3 E 245 G.s4h3.14
Van-der-waals C-term Y 438 - G.s4h3 E 245 G.s4h3.14
Hydrophobic ICL2 L 160 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 L 160 34x51 G.H5 I 348 G.H5.15
Polar C-term P 428 - G.H3 Y 261 G.H3.15
Hydrophobic C-term P 428 - G.H3 Y 261 G.H3.15
Van-der-waals C-term P 428 - G.H3 Y 261 G.H3.15
Hydrophobic TM2 T 89 2x39 G.H5 E 355 G.H5.22
Van-der-waals TM2 T 89 2x39 G.H5 E 355 G.H5.22
Hydrophobic TM3 I 156 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 156 3x54 G.H5 L 353 G.H5.20
Hydrophobic TM4 T 167 4x38 G.hns1 R 37 G.hns1.02
Van-der-waals TM4 T 167 4x38 G.hns1 R 37 G.hns1.02
Polar H8 H 394 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 H 394 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 H 394 8x47 G.H5 N 357 G.H5.24
Hydrophobic C-term L 433 - G.h2s4 F 220 G.h2s4.01
Hydrophobic ICL2 L 160 34x51 G.S1 L 40 G.S1.02
Hydrophobic C-term P 428 - G.H3 P 262 G.H3.16
Hydrophobic TM5 L 245 5x65 G.H5 L 353 G.H5.20
Polar TM7 Y 390 7x53 G.H5 N 357 G.H5.24
Hydrophobic TM6 V 331 6x33 G.H5 V 359 G.H5.26
Polar C-term S 432 - G.H3 Y 261 G.H3.15
Van-der-waals C-term S 432 - G.H3 Y 261 G.H3.15
Hydrophobic C-term L 433 - G.H2 W 216 G.H2.07
Polar ICL2 R 163 34x54 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 R 163 34x54 G.hns1 R 37 G.hns1.02
Polar TM2 V 88 2x38 G.H5 E 355 G.H5.22
Hydrophobic TM3 I 156 3x54 G.H5 L 358 G.H5.25
Hydrophobic ICL2 P 159 34x50 G.H5 I 348 G.H5.15
Hydrophobic C-term I 430 - G.H2 R 214 G.H2.05
Van-der-waals C-term I 430 - G.H2 R 214 G.H2.05
Hydrophobic TM6 L 335 6x37 G.H5 L 358 G.H5.25