G15 - GHRH receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 25.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 Y 226 3x53 G.H5 Y 367 G.H5.19
Polar ICL1 H 158 12x51 G.hns1 R 40 G.hns1.02
Hydrophobic ICL1 H 158 12x51 G.hns1 R 40 G.hns1.02
Van-der-waals ICL1 H 158 12x51 G.hns1 R 40 G.hns1.02
Polar ICL2 S 235 - G.s2s3 K 201 G.s2s3.02
Hydrophobic ICL2 S 235 - G.s2s3 K 201 G.s2s3.02
Van-der-waals ICL2 S 235 - G.s2s3 K 201 G.s2s3.02
Hydrophobic ICL3 Q 315 - G.H4 L 313 G.H4.12
Van-der-waals ICL3 Q 315 - G.H4 L 313 G.H4.12
Polar TM6 K 329 6x40 G.H5 L 374 G.H5.26
Van-der-waals TM6 K 329 6x40 G.H5 L 374 G.H5.26
Polar TM6 K 329 6x40 G.H5 N 372 G.H5.24
Hydrophobic TM6 K 329 6x40 G.H5 N 372 G.H5.24
Van-der-waals TM6 K 329 6x40 G.H5 N 372 G.H5.24
Polar TM7 L 375 7x56 G.H5 N 372 G.H5.24
Van-der-waals TM7 L 375 7x56 G.H5 N 372 G.H5.24
Ionic TM5 K 310 5x64 G.H5 D 361 G.H5.13
Polar TM5 K 310 5x64 G.H5 D 361 G.H5.13
Hydrophobic TM5 K 310 5x64 G.H5 D 361 G.H5.13
Van-der-waals TM5 K 310 5x64 G.H5 D 361 G.H5.13
Hydrophobic TM5 I 306 5x60 G.H5 L 364 G.H5.16
Hydrophobic TM2 C 159 2x44 G.hns1 R 40 G.hns1.02
Hydrophobic C-term W 408 - G.H2 K 218 G.H2.06
Aromatic TM2 R 161 2x46 G.H5 Y 367 G.H5.19
Hydrophobic TM2 R 161 2x46 G.H5 Y 367 G.H5.19
Van-der-waals TM2 R 161 2x46 G.H5 Y 367 G.H5.19
Hydrophobic TM5 L 307 5x61 G.H5 L 368 G.H5.20
Van-der-waals TM5 L 307 5x61 G.H5 L 368 G.H5.20
Hydrophobic TM4 R 239 4x40 G.HN K 37 G.HN.52
Van-der-waals TM4 R 239 4x40 G.HN K 37 G.HN.52
Hydrophobic ICL2 T 234 - G.H5 F 356 G.H5.08
Van-der-waals ICL2 T 234 - G.H5 F 356 G.H5.08
Hydrophobic TM3 L 227 3x54 G.H5 Y 367 G.H5.19
Van-der-waals TM3 L 227 3x54 G.H5 Y 367 G.H5.19
Hydrophobic C-term L 419 - G.h1ha Y 70 G.h1ha.04
Hydrophobic TM3 L 227 3x54 G.H5 I 371 G.H5.23
Polar TM7 L 379 7x60 G.H5 N 372 G.H5.24
Hydrophobic TM7 L 379 7x60 G.H5 N 372 G.H5.24
Van-der-waals TM7 L 379 7x60 G.H5 N 372 G.H5.24
Hydrophobic TM6 F 333 6x44 G.H5 N 372 G.H5.24
Van-der-waals TM6 F 333 6x44 G.H5 N 372 G.H5.24
Polar C-term W 408 - G.H2 H 221 G.H2.09
Aromatic C-term W 408 - G.H2 H 221 G.H2.09
Hydrophobic C-term W 408 - G.H2 H 221 G.H2.09
Van-der-waals C-term W 408 - G.H2 H 221 G.H2.09
Hydrophobic TM6 L 334 6x45 G.H5 L 373 G.H5.25
Van-der-waals TM6 L 334 6x45 G.H5 L 373 G.H5.25
Hydrophobic C-term L 419 - G.H1 R 63 G.H1.09
Van-der-waals C-term L 419 - G.H1 R 63 G.H1.09
Hydrophobic H8 R 403 8x70 G.H3 W 266 G.H3.17
Van-der-waals H8 R 403 8x70 G.H3 W 266 G.H3.17
Hydrophobic C-term W 408 - G.S2 I 192 G.S2.01
Van-der-waals C-term W 408 - G.S2 I 192 G.S2.01
Polar C-term C 423 - G.S2 C 196 G.S2.05
Hydrophobic C-term C 423 - G.S2 C 196 G.S2.05
Van-der-waals C-term C 423 - G.S2 C 196 G.S2.05
Polar ICL2 S 235 - G.s2s3 Q 200 G.s2s3.01
Polar ICL2 S 235 - G.S3 T 202 G.S3.01
Hydrophobic ICL2 S 235 - G.S3 T 202 G.S3.01
Van-der-waals ICL2 S 235 - G.S3 T 202 G.S3.01
Hydrophobic TM6 R 326 6x37 G.H5 L 374 G.H5.26
Hydrophobic TM5 K 310 5x64 G.H5 L 364 G.H5.16
Polar H8 N 380 8x47 G.H5 E 370 G.H5.22
Hydrophobic H8 N 380 8x47 G.H5 E 370 G.H5.22
Van-der-waals H8 N 380 8x47 G.H5 E 370 G.H5.22
Hydrophobic H8 N 380 8x47 G.H5 N 372 G.H5.24
Van-der-waals H8 N 380 8x47 G.H5 N 372 G.H5.24
Hydrophobic TM7 Y 376 7x57 G.H5 I 371 G.H5.23
Van-der-waals TM7 Y 376 7x57 G.H5 I 371 G.H5.23
Polar C-term S 421 - G.S2 C 196 G.S2.05
Van-der-waals C-term S 421 - G.S2 C 196 G.S2.05
Polar ICL2 T 234 - G.s2s3 Q 200 G.s2s3.01
Hydrophobic ICL2 T 234 - G.s2s3 Q 200 G.s2s3.01
Van-der-waals ICL2 T 234 - G.s2s3 Q 200 G.s2s3.01
Ionic H8 R 403 8x70 G.h2s4 E 224 G.h2s4.02
Polar H8 R 403 8x70 G.h2s4 E 224 G.h2s4.02
Hydrophobic H8 R 403 8x70 G.h2s4 E 224 G.h2s4.02
Van-der-waals H8 R 403 8x70 G.h2s4 E 224 G.h2s4.02
Polar TM5 K 310 5x64 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM5 K 310 5x64 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM6 K 329 6x40 G.h4s6 R 335 G.h4s6.17
Ionic TM2 R 161 2x46 G.H5 E 370 G.H5.22
Polar TM2 R 161 2x46 G.H5 E 370 G.H5.22
Hydrophobic TM2 R 161 2x46 G.H5 E 370 G.H5.22
Van-der-waals TM2 R 161 2x46 G.H5 E 370 G.H5.22
Hydrophobic TM2 R 161 2x46 G.H5 I 371 G.H5.23
Van-der-waals TM2 R 161 2x46 G.H5 I 371 G.H5.23
Hydrophobic TM3 L 231 3x58 G.H5 L 364 G.H5.16
Van-der-waals TM3 L 231 3x58 G.H5 L 364 G.H5.16
Polar TM6 S 330 6x41 G.H5 L 373 G.H5.25
Hydrophobic TM6 S 330 6x41 G.H5 L 373 G.H5.25
Van-der-waals TM6 S 330 6x41 G.H5 L 373 G.H5.25
Hydrophobic TM6 F 333 6x44 G.H5 L 373 G.H5.25
Van-der-waals TM6 F 333 6x44 G.H5 L 373 G.H5.25
Hydrophobic TM3 L 230 3x57 G.H5 Y 367 G.H5.19
Van-der-waals TM3 L 230 3x57 G.H5 Y 367 G.H5.19
Polar ICL2 T 234 - G.S3 T 202 G.S3.01
Hydrophobic ICL2 T 234 - G.S3 T 202 G.S3.01
Van-der-waals ICL2 T 234 - G.S3 T 202 G.S3.01
Hydrophobic C-term L 419 - H.HA E 74 H.HA.03
Van-der-waals C-term L 419 - H.HA E 74 H.HA.03
Hydrophobic H8 W 402 8x69 G.HN R 3 G.HN.03
Van-der-waals H8 W 402 8x69 G.HN R 3 G.HN.03
Hydrophobic TM2 H 165 2x50 G.H5 I 371 G.H5.23
Hydrophobic C-term A 406 - G.H2 H 221 G.H2.09
Van-der-waals C-term A 406 - G.H2 H 221 G.H2.09