Ggust - GHRH receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 T 234 - G.s2s3 K 192 G.s2s3.01
Hydrophobic TM5 K 310 5x64 G.H5 L 348 G.H5.20
Hydrophobic TM6 F 333 6x44 G.H5 L 353 G.H5.25
Polar C-term W 408 - G.H3 H 256 G.H3.15
Van-der-waals C-term W 408 - G.H3 H 256 G.H3.15
Hydrophobic TM5 L 307 5x61 G.H5 L 348 G.H5.20
Ionic TM5 K 310 5x64 G.H5 D 341 G.H5.13
Polar TM5 K 310 5x64 G.H5 D 341 G.H5.13
Hydrophobic TM5 K 310 5x64 G.H5 D 341 G.H5.13
Van-der-waals TM5 K 310 5x64 G.H5 D 341 G.H5.13
Hydrophobic C-term W 408 - G.H2 I 212 G.H2.08
Hydrophobic ICL2 T 234 - G.H5 F 336 G.H5.08
Van-der-waals ICL2 T 234 - G.H5 F 336 G.H5.08
Hydrophobic ICL2 P 236 - G.S3 L 194 G.S3.01
Hydrophobic ICL3 A 314 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 A 314 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 Q 315 - G.h4s6 N 311 G.h4s6.02
Polar H8 T 404 8x71 G.H3 K 257 G.H3.16
Van-der-waals H8 T 404 8x71 G.H3 K 257 G.H3.16
Polar H8 T 404 8x71 G.H3 Y 258 G.H3.17
Van-der-waals H8 T 404 8x71 G.H3 Y 258 G.H3.17
Hydrophobic ICL2 T 234 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 T 234 - G.H5 T 340 G.H5.12
Hydrophobic TM5 I 306 5x60 G.H5 I 344 G.H5.16
Hydrophobic ICL3 Q 315 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 Q 315 - G.S6 I 319 G.S6.01
Polar TM3 L 230 3x57 G.H5 N 347 G.H5.19
Van-der-waals TM3 L 230 3x57 G.H5 N 347 G.H5.19
Hydrophobic ICL2 S 235 - G.S3 L 194 G.S3.01
Hydrophobic C-term A 406 - G.H3 K 257 G.H3.16
Van-der-waals C-term A 406 - G.H3 K 257 G.H3.16
Ionic ICL1 R 155 12x48 G.HN E 20 G.HN.44
Polar ICL1 R 155 12x48 G.HN E 20 G.HN.44
Hydrophobic ICL3 Q 315 - G.H4 L 308 G.H4.16
Van-der-waals ICL3 Q 315 - G.H4 L 308 G.H4.16
Hydrophobic TM3 L 231 3x58 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 231 3x58 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 311 5x65 G.H5 F 354 G.H5.26
Van-der-waals TM5 L 311 5x65 G.H5 F 354 G.H5.26
Ionic TM4 R 239 4x40 G.HN E 28 G.HN.52
Polar TM4 R 239 4x40 G.HN E 28 G.HN.52
Hydrophobic TM4 R 239 4x40 G.HN E 28 G.HN.52
Van-der-waals TM4 R 239 4x40 G.HN E 28 G.HN.52
Polar H8 R 405 8x72 G.H3 Y 258 G.H3.17
Van-der-waals H8 R 405 8x72 G.H3 Y 258 G.H3.17
Polar ICL2 S 237 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 S 237 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 L 334 6x45 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 334 6x45 G.H5 L 353 G.H5.25
Hydrophobic TM3 L 231 3x58 G.H5 N 347 G.H5.19
Polar TM6 R 326 6x37 G.H5 F 354 G.H5.26
Aromatic TM6 R 326 6x37 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 326 6x37 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 326 6x37 G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 236 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 P 236 - G.hns1 A 31 G.hns1.02
Hydrophobic TM5 L 307 5x61 G.H5 F 354 G.H5.26
Polar H8 R 403 8x70 G.H3 Y 258 G.H3.17
Hydrophobic H8 R 403 8x70 G.H3 Y 258 G.H3.17
Van-der-waals H8 R 403 8x70 G.H3 Y 258 G.H3.17
Hydrophobic ICL2 T 234 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 T 234 - G.S3 L 194 G.S3.01
Hydrophobic TM3 L 227 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 227 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM3 L 227 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 L 227 3x54 G.H5 L 353 G.H5.25
Polar TM6 S 330 6x41 G.H5 L 353 G.H5.25
Hydrophobic TM6 S 330 6x41 G.H5 L 353 G.H5.25
Van-der-waals TM6 S 330 6x41 G.H5 L 353 G.H5.25
Hydrophobic ICL2 S 235 - G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 K 310 5x64 G.H5 F 354 G.H5.26
Polar C-term A 406 - G.H3 Y 258 G.H3.17
Van-der-waals C-term A 406 - G.H3 Y 258 G.H3.17
Hydrophobic ICL2 P 236 - G.hns1 R 32 G.hns1.03
Polar TM2 R 161 2x46 G.H5 D 350 G.H5.22
Hydrophobic TM2 R 161 2x46 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 161 2x46 G.H5 D 350 G.H5.22
Hydrophobic TM2 R 161 2x46 G.H5 C 351 G.H5.23
Polar TM4 R 239 4x40 G.HN Q 24 G.HN.48
Hydrophobic TM4 R 239 4x40 G.HN Q 24 G.HN.48
Van-der-waals TM4 R 239 4x40 G.HN Q 24 G.HN.48
Polar TM5 K 310 5x64 G.H5 K 345 G.H5.17
Hydrophobic TM5 K 310 5x64 G.H5 K 345 G.H5.17
Hydrophobic TM5 K 310 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 K 310 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM3 L 231 3x58 G.H5 I 344 G.H5.16