G12 - GIP receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 25.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 G 249 - G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 G 249 - G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 G 249 - G.s2s3 K 220 G.s2s3.02
Hydrophobic TM6 T 345 6x44 G.H5 L 380 G.H5.25
Van-der-waals TM6 T 345 6x44 G.H5 L 380 G.H5.25
Hydrophobic TM5 K 324 5x64 G.H5 Q 372 G.H5.17
Van-der-waals TM5 K 324 5x64 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 V 248 - G.S2 I 218 G.S2.08
Van-der-waals ICL2 V 248 - G.S2 I 218 G.S2.08
Ionic TM5 K 324 5x64 G.H5 D 368 G.H5.13
Polar TM5 K 324 5x64 G.H5 D 368 G.H5.13
Hydrophobic TM5 K 324 5x64 G.H5 D 368 G.H5.13
Van-der-waals TM5 K 324 5x64 G.H5 D 368 G.H5.13
Ionic TM6 R 338 6x37 G.H5 E 373 G.H5.18
Polar TM6 R 338 6x37 G.H5 E 373 G.H5.18
Polar TM2 R 169 2x46 G.H5 Q 381 G.H5.26
Hydrophobic TM2 R 169 2x46 G.H5 Q 381 G.H5.26
Van-der-waals TM2 R 169 2x46 G.H5 Q 381 G.H5.26
Hydrophobic TM3 L 244 3x57 G.H5 I 378 G.H5.23
Hydrophobic H8 E 398 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 E 398 8x49 G.H5 Q 381 G.H5.26
Hydrophobic TM3 L 241 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 L 241 3x54 G.H5 L 375 G.H5.20
Polar TM5 L 321 5x61 G.H5 Q 372 G.H5.17
Hydrophobic TM5 L 321 5x61 G.H5 Q 372 G.H5.17
Van-der-waals TM5 L 321 5x61 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 V 248 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 V 248 - G.S3 I 221 G.S3.01
Hydrophobic ICL2 G 249 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 G 249 - G.S3 I 221 G.S3.01
Hydrophobic ICL3 M 330 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 M 330 - G.S6 F 347 G.S6.02
Hydrophobic TM3 L 245 3x58 G.H5 L 375 G.H5.20
Van-der-waals TM3 L 245 3x58 G.H5 L 375 G.H5.20
Hydrophobic TM5 K 324 5x64 G.H5 T 369 G.H5.14
Polar TM2 C 167 2x44 G.hns1 R 55 G.hns1.02
Hydrophobic TM2 C 167 2x44 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 C 167 2x44 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 L 244 3x57 G.H5 L 375 G.H5.20
Hydrophobic TM5 L 321 5x61 G.H5 K 376 G.H5.21
Van-der-waals TM5 L 321 5x61 G.H5 K 376 G.H5.21
Ionic TM5 R 328 5x68 G.H5 E 373 G.H5.18
Polar TM5 R 328 5x68 G.H5 E 373 G.H5.18
Hydrophobic TM5 R 328 5x68 G.H5 E 373 G.H5.18
Van-der-waals TM5 R 328 5x68 G.H5 E 373 G.H5.18
Polar TM6 S 342 6x41 G.H5 K 376 G.H5.21
Van-der-waals TM6 S 342 6x41 G.H5 K 376 G.H5.21
Hydrophobic ICL3 M 330 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 M 330 - G.h4s6 P 345 G.h4s6.20
Polar TM2 T 168 2x45 G.HN R 52 G.HN.52
Van-der-waals TM2 T 168 2x45 G.HN R 52 G.HN.52
Ionic ICL2 E 253 - G.HN R 52 G.HN.52
Polar ICL2 E 253 - G.HN R 52 G.HN.52
Hydrophobic ICL2 E 253 - G.HN R 52 G.HN.52
Van-der-waals ICL2 E 253 - G.HN R 52 G.HN.52
Polar TM7 Y 392 7x57 G.H5 M 379 G.H5.24
Hydrophobic TM7 Y 392 7x57 G.H5 M 379 G.H5.24
Van-der-waals TM7 Y 392 7x57 G.H5 M 379 G.H5.24
Hydrophobic ICL2 V 248 - G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 V 248 - G.s2s3 K 220 G.s2s3.02
Polar TM5 R 328 5x68 G.H5 T 369 G.H5.14
Hydrophobic TM5 R 328 5x68 G.H5 T 369 G.H5.14
Van-der-waals TM5 R 328 5x68 G.H5 T 369 G.H5.14
Hydrophobic TM6 L 346 6x45 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 346 6x45 G.H5 M 379 G.H5.24
Hydrophobic ICL2 V 248 - G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL2 V 248 - G.s2s3 K 219 G.s2s3.01
Polar ICL2 S 251 - G.hns1 R 56 G.hns1.03
Polar H8 N 396 8x47 G.H5 Q 381 G.H5.26
Hydrophobic H8 N 396 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 396 8x47 G.H5 Q 381 G.H5.26
Ionic H8 E 398 8x49 G.hns1 R 55 G.hns1.02
Polar H8 E 398 8x49 G.hns1 R 55 G.hns1.02
Polar TM3 S 243 3x56 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 G 249 - G.S3 P 222 G.S3.02
Ionic ICL2 E 252 - G.hns1 R 56 G.hns1.03
Polar ICL2 E 252 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 E 252 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 E 252 - G.hns1 R 56 G.hns1.03
Hydrophobic C-term Y 465 - G.H3 E 278 G.H3.10
Van-der-waals C-term Y 465 - G.H3 E 278 G.H3.10
Polar TM2 R 169 2x46 G.H5 I 378 G.H5.23
Hydrophobic TM2 R 169 2x46 G.H5 I 378 G.H5.23
Van-der-waals TM2 R 169 2x46 G.H5 I 378 G.H5.23
Hydrophobic TM3 L 241 3x54 G.H5 M 379 G.H5.24
Van-der-waals TM3 L 241 3x54 G.H5 M 379 G.H5.24
Aromatic TM5 R 328 5x68 G.S6 F 347 G.S6.02
Hydrophobic TM5 R 328 5x68 G.S6 F 347 G.S6.02
Van-der-waals TM5 R 328 5x68 G.S6 F 347 G.S6.02
Hydrophobic TM3 L 244 3x57 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 F 256 4x43 G.HN R 52 G.HN.52
Polar TM5 I 320 5x60 G.H5 Q 372 G.H5.17
Van-der-waals TM5 I 320 5x60 G.H5 Q 372 G.H5.17
Polar ICL3 Q 329 - G.S6 H 348 G.S6.03
Hydrophobic H8 N 396 8x47 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 392 7x57 G.H5 Q 381 G.H5.26
Ionic ICL2 E 253 - G.HN R 49 G.HN.49
Polar ICL2 E 253 - G.HN R 49 G.HN.49
Hydrophobic ICL2 E 253 - G.HN R 49 G.HN.49
Van-der-waals ICL2 E 253 - G.HN R 49 G.HN.49
Polar ICL2 G 250 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 G 250 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 G 250 - G.hns1 R 56 G.hns1.03