Gs - GPR107 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 70.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 28.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 I 358 - G.H5 Q 390 G.H5.22
Polar C-term Q 556 - G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term Q 556 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term Q 556 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term Q 559 - G.h4s6 G 353 G.h4s6.09
Polar TM4 K 367 4x43 G.h2s4 N 239 G.h2s4.02
Van-der-waals TM4 K 367 4x43 G.h2s4 N 239 G.h2s4.02
Hydrophobic ICL2 I 361 - G.H3 W 281 G.H3.17
Polar C-term E 562 - G.h4s6 S 352 G.h4s6.08
Hydrophobic C-term E 562 - G.h4s6 S 352 G.h4s6.08
Van-der-waals C-term E 562 - G.h4s6 S 352 G.h4s6.08
Hydrophobic TM5 A 429 5x64 G.H5 L 388 G.H5.20
Van-der-waals TM5 A 429 5x64 G.H5 L 388 G.H5.20
Polar C-term S 558 - G.h4s6 H 357 G.h4s6.13
Hydrophobic C-term S 558 - G.h4s6 H 357 G.h4s6.13
Van-der-waals C-term S 558 - G.h4s6 H 357 G.h4s6.13
Hydrophobic TM6 K 490 6x32 G.H5 R 389 G.H5.21
Van-der-waals TM6 K 490 6x32 G.H5 R 389 G.H5.21
Polar C-term S 558 - G.h4s6 D 354 G.h4s6.10
Hydrophobic C-term S 558 - G.h4s6 D 354 G.h4s6.10
Van-der-waals C-term S 558 - G.h4s6 D 354 G.h4s6.10
Hydrophobic C-term E 560 - G.h4s6 S 352 G.h4s6.08
Hydrophobic ICL2 I 358 - G.H5 R 389 G.H5.21
Polar C-term L 557 - G.h4s6 H 357 G.h4s6.13
Hydrophobic C-term L 557 - G.h4s6 H 357 G.h4s6.13
Van-der-waals C-term L 557 - G.h4s6 H 357 G.h4s6.13
Polar ICL1 D 290 - G.h4s6 R 356 G.h4s6.12
Van-der-waals ICL1 D 290 - G.h4s6 R 356 G.h4s6.12
Ionic TM4 D 366 4x42 G.hns1 R 38 G.hns1.02
Polar TM4 D 366 4x42 G.hns1 R 38 G.hns1.02
Van-der-waals TM4 D 366 4x42 G.hns1 R 38 G.hns1.02
Hydrophobic TM6 A 484 6x26 G.H5 R 385 G.H5.17
Polar C-term E 562 - G.H3 N 278 G.H3.14
Hydrophobic C-term E 562 - G.H3 N 278 G.H3.14
Van-der-waals C-term E 562 - G.H3 N 278 G.H3.14
Hydrophobic TM6 I 486 6x28 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 I 486 6x28 G.h4s6 Y 358 G.h4s6.20
Ionic C-term E 562 - G.h3s5 R 283 G.h3s5.01
Polar C-term E 562 - G.h3s5 R 283 G.h3s5.01
Hydrophobic C-term E 562 - G.h3s5 R 283 G.h3s5.01
Van-der-waals C-term E 562 - G.h3s5 R 283 G.h3s5.01
Polar TM5 S 422 5x57 G.H5 Y 391 G.H5.23
Van-der-waals TM5 S 422 5x57 G.H5 Y 391 G.H5.23
Hydrophobic TM5 H 425 5x60 G.H5 L 393 G.H5.25
Van-der-waals TM5 H 425 5x60 G.H5 L 393 G.H5.25
Polar TM6 N 487 6x29 G.H5 R 389 G.H5.21
Hydrophobic TM6 N 487 6x29 G.H5 R 389 G.H5.21
Van-der-waals TM6 N 487 6x29 G.H5 R 389 G.H5.21
Hydrophobic C-term E 562 - G.H3 W 277 G.H3.13
Polar ICL2 K 359 - G.h3s5 T 284 G.h3s5.02
Hydrophobic ICL2 K 359 - G.h3s5 T 284 G.h3s5.02
Van-der-waals ICL2 K 359 - G.h3s5 T 284 G.h3s5.02
Polar C-term Q 556 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 T 483 6x25 G.S6 Y 360 G.S6.02
Polar ICL2 K 359 - G.H5 Y 391 G.H5.23
Aromatic ICL2 K 359 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 K 359 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 K 359 - G.H5 Y 391 G.H5.23
Polar C-term Q 559 - G.h4s6 A 351 G.h4s6.04
Hydrophobic ICL2 F 357 - G.h3s5 T 284 G.h3s5.02
Van-der-waals ICL2 F 357 - G.h3s5 T 284 G.h3s5.02
Polar C-term Q 559 - G.h4s6 S 352 G.h4s6.08
Hydrophobic C-term Q 559 - G.h4s6 S 352 G.h4s6.08
Van-der-waals C-term Q 559 - G.h4s6 S 352 G.h4s6.08
Hydrophobic ICL2 I 361 - G.h2s4 F 238 G.h2s4.01
Hydrophobic ICL2 H 360 - G.h3s5 R 283 G.h3s5.01
Van-der-waals ICL2 H 360 - G.h3s5 R 283 G.h3s5.01
Aromatic TM2 F 292 2x36 G.h4s6 R 356 G.h4s6.12
Hydrophobic TM2 F 292 2x36 G.h4s6 R 356 G.h4s6.12
Van-der-waals TM2 F 292 2x36 G.h4s6 R 356 G.h4s6.12
Ionic C-term E 565 - G.H3 K 274 G.H3.10
Polar C-term E 565 - G.H3 K 274 G.H3.10
Hydrophobic C-term E 565 - G.H3 K 274 G.H3.10
Van-der-waals C-term E 565 - G.H3 K 274 G.H3.10
Polar C-term Q 556 - G.h4s6 D 354 G.h4s6.10
Hydrophobic C-term Q 556 - G.h4s6 D 354 G.h4s6.10
Van-der-waals C-term Q 556 - G.h4s6 D 354 G.h4s6.10
Hydrophobic TM3 G 352 3x51 G.H5 E 392 G.H5.24
Van-der-waals TM3 G 352 3x51 G.H5 E 392 G.H5.24
Polar ICL2 H 360 - G.H3 R 280 G.H3.16
Hydrophobic ICL2 H 360 - G.H3 R 280 G.H3.16
Van-der-waals ICL2 H 360 - G.H3 R 280 G.H3.16
Hydrophobic C-term M 566 - G.H3 N 278 G.H3.14
Van-der-waals C-term M 566 - G.H3 N 278 G.H3.14
Hydrophobic TM6 N 487 6x29 G.H5 R 385 G.H5.17
Hydrophobic TM4 S 363 4x39 G.h2s4 D 240 G.h2s4.03
Van-der-waals TM4 S 363 4x39 G.h2s4 D 240 G.h2s4.03
Polar C-term E 560 - G.h4s6 A 351 G.h4s6.04
Hydrophobic C-term E 560 - G.h4s6 A 351 G.h4s6.04
Van-der-waals C-term E 560 - G.h4s6 A 351 G.h4s6.04
Ionic C-term E 561 - G.H3 K 274 G.H3.10
Polar C-term E 561 - G.H3 K 274 G.H3.10
Hydrophobic C-term E 561 - G.H3 K 274 G.H3.10
Van-der-waals C-term E 561 - G.H3 K 274 G.H3.10
Hydrophobic TM4 K 365 4x41 G.HN Q 35 G.HN.52
Van-der-waals TM4 K 365 4x41 G.HN Q 35 G.HN.52
Polar C-term L 557 - G.h4s6 G 355 G.h4s6.11
Hydrophobic C-term L 557 - G.h4s6 G 355 G.h4s6.11
Van-der-waals C-term L 557 - G.h4s6 G 355 G.h4s6.11
Hydrophobic TM5 S 422 5x57 G.H5 E 392 G.H5.24
Polar TM4 D 364 4x40 G.h2s4 N 239 G.h2s4.02
Van-der-waals TM4 D 364 4x40 G.h2s4 N 239 G.h2s4.02
Ionic TM5 D 433 5x68 G.H5 R 385 G.H5.17
Polar TM5 D 433 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 D 433 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 D 433 5x68 G.H5 R 385 G.H5.17
Polar TM6 K 490 6x32 G.h4s6 G 355 G.h4s6.11
Van-der-waals TM6 K 490 6x32 G.h4s6 G 355 G.h4s6.11
Polar ICL1 V 291 - G.h4s6 R 356 G.h4s6.12
Van-der-waals ICL1 V 291 - G.h4s6 R 356 G.h4s6.12
Hydrophobic TM4 S 363 4x39 G.H5 Y 391 G.H5.23
Ionic C-term E 562 - G.h4s6 H 357 G.h4s6.13
Polar C-term E 562 - G.h4s6 H 357 G.h4s6.13
Ionic ICL2 K 359 - G.h2s4 D 240 G.h2s4.03
Polar ICL2 K 359 - G.h2s4 D 240 G.h2s4.03
Van-der-waals ICL2 K 359 - G.h2s4 D 240 G.h2s4.03
Hydrophobic TM4 K 365 4x41 G.hns1 R 38 G.hns1.02
Van-der-waals TM4 K 365 4x41 G.hns1 R 38 G.hns1.02
Hydrophobic TM6 L 491 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 491 6x33 G.H5 L 393 G.H5.25
Polar ICL2 K 359 - G.H5 Q 390 G.H5.22
Hydrophobic ICL2 K 359 - G.H5 Q 390 G.H5.22
Van-der-waals ICL2 K 359 - G.H5 Q 390 G.H5.22
Hydrophobic TM5 H 425 5x60 G.H5 L 388 G.H5.20
Van-der-waals TM5 H 425 5x60 G.H5 L 388 G.H5.20
Hydrophobic TM5 L 426 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 426 5x61 G.H5 L 393 G.H5.25
Hydrophobic C-term M 566 - G.H3 N 279 G.H3.15
Hydrophobic TM5 L 426 5x61 G.H5 E 392 G.H5.24
Van-der-waals TM5 L 426 5x61 G.H5 E 392 G.H5.24
Polar TM5 S 422 5x57 G.hns1 R 38 G.hns1.02
Polar TM3 T 353 3x52 G.H5 E 392 G.H5.24
Hydrophobic TM3 T 353 3x52 G.H5 E 392 G.H5.24
Van-der-waals TM3 T 353 3x52 G.H5 E 392 G.H5.24
Hydrophobic ICL2 I 361 - G.h2s4 N 239 G.h2s4.02
Van-der-waals ICL2 I 361 - G.h2s4 N 239 G.h2s4.02
Ionic TM6 R 479 6x21 G.hgh4 D 323 G.hgh4.13
Polar TM6 R 479 6x21 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM6 R 479 6x21 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM6 R 479 6x21 G.hgh4 D 323 G.hgh4.13
Polar TM6 Y 498 6x40 G.H5 E 392 G.H5.24
Hydrophobic TM6 Y 498 6x40 G.H5 E 392 G.H5.24
Van-der-waals TM6 Y 498 6x40 G.H5 E 392 G.H5.24
Polar TM4 K 365 4x41 G.HN K 34 G.HN.51
Hydrophobic TM4 K 365 4x41 G.HN K 34 G.HN.51
Van-der-waals TM4 K 365 4x41 G.HN K 34 G.HN.51
Hydrophobic TM5 A 429 5x64 G.H5 L 394 G.H5.26
Hydrophobic TM5 S 430 5x65 G.H5 L 394 G.H5.26
Hydrophobic C-term S 558 - G.h4s6 G 353 G.h4s6.09
Van-der-waals C-term S 558 - G.h4s6 G 353 G.h4s6.09
Polar ICL2 H 360 - G.h3s5 T 284 G.h3s5.02
Hydrophobic ICL2 H 360 - G.h3s5 T 284 G.h3s5.02
Van-der-waals ICL2 H 360 - G.h3s5 T 284 G.h3s5.02
Hydrophobic TM5 W 421 5x56 G.HN Q 35 G.HN.52
Van-der-waals TM5 W 421 5x56 G.HN Q 35 G.HN.52
Polar ICL2 I 358 - G.h3s5 T 284 G.h3s5.02
Hydrophobic ICL2 I 358 - G.h3s5 T 284 G.h3s5.02
Van-der-waals ICL2 I 358 - G.h3s5 T 284 G.h3s5.02
Hydrophobic TM5 S 422 5x57 G.H5 L 393 G.H5.25
Van-der-waals TM5 S 422 5x57 G.H5 L 393 G.H5.25
Polar C-term S 558 - G.h4s6 S 352 G.h4s6.08
Hydrophobic C-term S 558 - G.h4s6 S 352 G.h4s6.08
Van-der-waals C-term S 558 - G.h4s6 S 352 G.h4s6.08
Hydrophobic C-term L 557 - G.h3s5 R 283 G.h3s5.01
Van-der-waals C-term L 557 - G.h3s5 R 283 G.h3s5.01
Polar C-term E 561 - G.h4s6 I 348 G.h4s6.01
Hydrophobic C-term E 561 - G.h4s6 I 348 G.h4s6.01
Van-der-waals C-term E 561 - G.h4s6 I 348 G.h4s6.01
Polar TM6 K 490 6x32 G.h4s6 R 356 G.h4s6.12
Hydrophobic TM6 K 490 6x32 G.h4s6 R 356 G.h4s6.12
Van-der-waals TM6 K 490 6x32 G.h4s6 R 356 G.h4s6.12
Polar TM4 D 364 4x40 G.h2s4 D 240 G.h2s4.03
Van-der-waals TM4 D 364 4x40 G.h2s4 D 240 G.h2s4.03
Polar C-term E 561 - G.h4s6 A 351 G.h4s6.04
Hydrophobic C-term E 561 - G.h4s6 A 351 G.h4s6.04
Polar TM6 L 491 6x33 G.H5 L 394 G.H5.26
Hydrophobic TM6 L 491 6x33 G.H5 L 394 G.H5.26
Van-der-waals TM6 L 491 6x33 G.H5 L 394 G.H5.26
Van-der-waals TM6 N 487 6x29 G.H5 L 394 G.H5.26
Polar C-term L 557 - G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term L 557 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term L 557 - G.h4s6 R 356 G.h4s6.12
Polar C-term Q 559 - G.h4s6 D 354 G.h4s6.10
Hydrophobic C-term Q 559 - G.h4s6 D 354 G.h4s6.10
Van-der-waals C-term Q 559 - G.h4s6 D 354 G.h4s6.10
Hydrophobic ICL2 F 357 - G.h4s6 R 356 G.h4s6.12
Van-der-waals ICL2 F 357 - G.h4s6 R 356 G.h4s6.12
Hydrophobic TM4 K 368 4x44 G.HN K 34 G.HN.51
Polar TM6 I 486 6x28 G.H5 R 389 G.H5.21
Van-der-waals TM6 I 486 6x28 G.H5 R 389 G.H5.21
Hydrophobic C-term E 561 - G.h4s6 S 352 G.h4s6.08
Van-der-waals C-term E 561 - G.h4s6 S 352 G.h4s6.08
Hydrophobic C-term Q 556 - G.h4s6 G 355 G.h4s6.11
Van-der-waals C-term Q 556 - G.h4s6 G 355 G.h4s6.11
Hydrophobic TM6 F 494 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 F 494 6x36 G.H5 E 392 G.H5.24
Polar C-term E 561 - G.H3 N 278 G.H3.14
Hydrophobic C-term E 561 - G.H3 N 278 G.H3.14
Van-der-waals C-term E 561 - G.H3 N 278 G.H3.14
Polar TM3 G 354 3x53 G.H5 E 392 G.H5.24
Van-der-waals TM3 G 354 3x53 G.H5 E 392 G.H5.24
Ionic C-term D 563 - G.h3s5 R 283 G.h3s5.01
Polar C-term D 563 - G.h3s5 R 283 G.h3s5.01
Van-der-waals C-term D 563 - G.h3s5 R 283 G.h3s5.01
Hydrophobic ICL2 H 360 - G.H3 W 281 G.H3.17
Van-der-waals ICL2 H 360 - G.H3 W 281 G.H3.17
Polar C-term S 558 - G.H3 W 277 G.H3.13
Hydrophobic C-term S 558 - G.H3 W 277 G.H3.13
Van-der-waals C-term S 558 - G.H3 W 277 G.H3.13
Polar C-term L 557 - G.h4s6 D 354 G.h4s6.10
Hydrophobic C-term L 557 - G.h4s6 D 354 G.h4s6.10
Van-der-waals C-term L 557 - G.h4s6 D 354 G.h4s6.10