G12 - GPR132 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 79.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 R 151 34x54 G.h2s4 T 246 G.h2s4.05
Hydrophobic ICL2 R 151 34x54 G.h2s4 T 246 G.h2s4.05
Van-der-waals ICL2 R 151 34x54 G.h2s4 T 246 G.h2s4.05
Hydrophobic ICL2 R 151 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 151 34x54 G.hns1 R 56 G.hns1.03
Polar TM6 Q 236 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 Q 236 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 Q 236 6x29 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 L 148 34x51 G.S3 F 223 G.S3.03
Hydrophobic TM5 I 222 5x61 G.H5 L 380 G.H5.25
Hydrophobic H8 T 312 8x47 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 A 147 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM5 I 226 5x65 G.H5 L 371 G.H5.16
Hydrophobic TM2 L 81 2x43 G.H5 M 379 G.H5.24
Van-der-waals TM2 L 81 2x43 G.H5 M 379 G.H5.24
Hydrophobic TM3 V 144 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 144 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM6 S 243 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 S 243 6x36 G.H5 L 380 G.H5.25
Polar TM2 N 75 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 N 75 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 N 75 2x37 G.H5 D 377 G.H5.22
Hydrophobic ICL2 R 154 34x57 G.H5 I 378 G.H5.23
Van-der-waals ICL2 R 154 34x57 G.H5 I 378 G.H5.23
Hydrophobic ICL3 L 232 - G.H5 L 371 G.H5.16
Polar TM3 V 145 3x55 G.H5 K 367 G.H5.12
Hydrophobic TM3 V 145 3x55 G.H5 K 367 G.H5.12
Van-der-waals TM3 V 145 3x55 G.H5 K 367 G.H5.12
Polar ICL2 R 151 34x54 G.S1 L 57 G.S1.01
Van-der-waals ICL2 R 151 34x54 G.S1 L 57 G.S1.01
Hydrophobic ICL2 E 149 34x52 G.S3 I 221 G.S3.01
Hydrophobic TM7 V 309 7x54 G.H5 M 379 G.H5.24
Polar TM3 R 140 3x50 G.H5 M 379 G.H5.24
Hydrophobic TM3 R 140 3x50 G.H5 M 379 G.H5.24
Van-der-waals TM3 R 140 3x50 G.H5 M 379 G.H5.24
Hydrophobic ICL2 R 151 34x54 G.H5 I 370 G.H5.15
Hydrophobic ICL3 G 231 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 G 231 - G.S6 F 347 G.S6.02
Hydrophobic ICL3 M 230 - G.S6 F 347 G.S6.02
Hydrophobic TM6 V 240 6x33 G.H5 L 380 G.H5.25
Polar ICL3 G 231 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 G 231 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 G 231 - G.H5 D 368 G.H5.13
Hydrophobic TM6 K 239 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 239 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM3 V 144 3x54 G.H5 L 375 G.H5.20
Polar TM5 S 229 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 S 229 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 S 229 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM3 A 143 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 143 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 148 34x51 G.H5 K 367 G.H5.12
Van-der-waals ICL2 L 148 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM2 L 77 2x39 G.H5 M 379 G.H5.24
Hydrophobic ICL3 L 232 - G.H5 L 375 G.H5.20
Van-der-waals ICL3 L 232 - G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 148 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 L 148 34x51 G.S1 V 58 G.S1.02
Polar ICL3 M 230 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 M 230 - G.H5 D 368 G.H5.13
Polar ICL2 A 147 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 A 147 34x50 G.H5 N 374 G.H5.19
Hydrophobic H8 T 312 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 T 312 8x47 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 148 34x51 G.H5 V 366 G.H5.11
Hydrophobic ICL3 L 232 - G.H5 Q 372 G.H5.17
Hydrophobic ICL2 A 147 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 A 147 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM7 Y 308 7x53 G.H5 M 379 G.H5.24
Van-der-waals TM7 Y 308 7x53 G.H5 M 379 G.H5.24
Hydrophobic ICL3 G 231 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 G 231 - G.h4s6 P 345 G.h4s6.20
Polar H8 D 313 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 D 313 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 D 313 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM5 I 226 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM6 V 240 6x33 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 148 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 148 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM4 R 155 4x38 G.HN R 52 G.HN.52
Van-der-waals TM4 R 155 4x38 G.HN R 52 G.HN.52
Hydrophobic ICL2 G 152 34x55 G.hns1 R 56 G.hns1.03
Polar ICL3 G 231 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 G 231 - G.H5 Q 372 G.H5.17
Polar TM3 R 140 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 A 147 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM1 Q 70 1x60 G.H5 M 379 G.H5.24
Van-der-waals TM1 Q 70 1x60 G.H5 M 379 G.H5.24
Polar TM3 A 143 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 143 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 143 3x53 G.H5 N 374 G.H5.19
Polar ICL2 R 151 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 R 151 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 L 148 34x51 G.S3 I 221 G.S3.01
Polar ICL2 G 152 34x55 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 G 152 34x55 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 V 144 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 144 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM3 R 140 3x50 G.H5 L 380 G.H5.25
Van-der-waals TM3 R 140 3x50 G.H5 L 380 G.H5.25
Hydrophobic TM2 L 77 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 L 77 2x39 G.H5 I 378 G.H5.23
Hydrophobic TM5 S 229 5x68 G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 148 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 148 34x51 G.H5 F 363 G.H5.08