GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM3 | A | 143 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 143 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 143 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | H8 | T | 312 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | T | 312 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Polar | ICL2 | G | 152 | 34x55 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | G | 152 | 34x55 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | G | 152 | 34x55 | G.hns1 | A | 31 | G.hns1.02 |
Polar | H8 | D | 313 | 8x48 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | ICL3 | L | 232 | - | G.H5 | I | 344 | G.H5.16 |
Ionic | TM4 | R | 155 | 4x38 | G.HN | E | 28 | G.HN.52 |
Polar | TM4 | R | 155 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM4 | R | 155 | 4x38 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | R | 155 | 4x38 | G.HN | E | 28 | G.HN.52 |
Polar | TM3 | R | 140 | 3x50 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM3 | R | 140 | 3x50 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | A | 147 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | A | 147 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Polar | ICL2 | R | 151 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | R | 151 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | R | 151 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Polar | ICL2 | R | 151 | 34x54 | G.S1 | E | 33 | G.S1.01 |
Hydrophobic | ICL2 | R | 151 | 34x54 | G.S1 | E | 33 | G.S1.01 |
Van-der-waals | ICL2 | R | 151 | 34x54 | G.S1 | E | 33 | G.S1.01 |
Polar | ICL2 | R | 154 | 34x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | L | 148 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | L | 148 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Polar | ICL3 | M | 230 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | M | 230 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | L | 232 | - | G.H5 | F | 354 | G.H5.26 |
Polar | TM6 | K | 239 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 239 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 239 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | L | 375 | - | G.H4 | E | 297 | G.H4.04 |
Van-der-waals | C-term | L | 375 | - | G.H4 | E | 297 | G.H4.04 |
Polar | TM2 | N | 75 | 2x37 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | N | 75 | 2x37 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM3 | V | 144 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL3 | G | 231 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | ICL2 | L | 148 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | ICL2 | A | 147 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | A | 147 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | L | 148 | 34x51 | G.S3 | F | 196 | G.S3.03 |
Polar | ICL2 | A | 147 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | A | 147 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL3 | L | 232 | - | G.H5 | K | 345 | G.H5.17 |
Polar | ICL2 | R | 151 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | R | 151 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | R | 151 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | L | 148 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | ICL2 | L | 148 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Polar | TM3 | R | 140 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 140 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 140 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | A | 143 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | A | 143 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Polar | C-term | C | 370 | - | G.H4 | D | 309 | G.H4.17 |
Hydrophobic | C-term | C | 370 | - | G.H4 | D | 309 | G.H4.17 |
Van-der-waals | C-term | C | 370 | - | G.H4 | D | 309 | G.H4.17 |
Hydrophobic | ICL2 | R | 151 | 34x54 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | R | 151 | 34x54 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | TM3 | V | 144 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM2 | L | 77 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | L | 77 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Ionic | ICL2 | R | 153 | 34x56 | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | ICL2 | R | 153 | 34x56 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 153 | 34x56 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | TM3 | R | 140 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 140 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | V | 144 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | V | 144 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Polar | ICL2 | E | 149 | 34x52 | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | ICL2 | E | 149 | 34x52 | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | TM5 | I | 226 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM5 | I | 226 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | S | 243 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | S | 243 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | L | 148 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | L | 148 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | C-term | L | 375 | - | G.H4 | A | 300 | G.H4.07 |
Hydrophobic | C-term | L | 375 | - | G.H4 | A | 301 | G.H4.08 |
Hydrophobic | ICL2 | R | 151 | 34x54 | G.S1 | V | 34 | G.S1.02 |
Hydrophobic | C-term | C | 370 | - | G.H4 | C | 305 | G.H4.13 |
Van-der-waals | C-term | C | 370 | - | G.H4 | C | 305 | G.H4.13 |
Hydrophobic | TM6 | V | 240 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | V | 240 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL2 | G | 152 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | G | 152 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | G | 152 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL3 | L | 232 | - | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | ICL3 | L | 232 | - | G.H5 | L | 348 | G.H5.20 |
Polar | ICL2 | R | 151 | 34x54 | G.h2s4 | T | 219 | G.h2s4.05 |
Hydrophobic | ICL2 | R | 151 | 34x54 | G.h2s4 | T | 219 | G.h2s4.05 |
Van-der-waals | ICL2 | R | 151 | 34x54 | G.h2s4 | T | 219 | G.h2s4.05 |
Hydrophobic | ICL2 | L | 148 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | L | 148 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | R | 153 | 34x56 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | R | 153 | 34x56 | G.hns1 | R | 32 | G.hns1.03 |
Polar | TM5 | S | 229 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | S | 229 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | S | 229 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | V | 240 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | Q | 236 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | Q | 236 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | L | 375 | - | G.S6 | F | 323 | G.S6.05 |
Van-der-waals | C-term | L | 375 | - | G.S6 | F | 323 | G.S6.05 |
Polar | ICL3 | G | 231 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | G | 231 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | G | 231 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL2 | L | 148 | 34x51 | G.S2 | F | 191 | G.S2.08 |
Hydrophobic | TM5 | I | 222 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Polar | TM6 | Q | 236 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | Q | 236 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM4 | R | 157 | 4x40 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | R | 157 | 4x40 | G.HN | R | 24 | G.HN.48 |