G14 - GPR135 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 68.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 15.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 T 138 2x39 G.H5 F 352 G.H5.23
Van-der-waals TM2 T 138 2x39 G.H5 F 352 G.H5.23
Hydrophobic TM5 V 311 5x72 G.H5 A 339 G.H5.10
Polar TM3 R 209 3x50 G.H5 V 355 G.H5.26
Van-der-waals TM3 R 209 3x50 G.H5 V 355 G.H5.26
Hydrophobic ICL3 Y 317 - G.h4s6 K 316 G.h4s6.11
Van-der-waals ICL3 Y 317 - G.h4s6 K 316 G.h4s6.11
Ionic TM6 R 322 6x26 G.H5 D 342 G.H5.13
Polar TM6 R 322 6x26 G.H5 D 342 G.H5.13
Hydrophobic TM6 R 322 6x26 G.H5 D 342 G.H5.13
Van-der-waals TM6 R 322 6x26 G.H5 D 342 G.H5.13
Polar TM6 E 326 6x30 G.H5 Q 346 G.H5.17
Van-der-waals TM6 E 326 6x30 G.H5 Q 346 G.H5.17
Hydrophobic ICL2 P 217 - G.S1 L 36 G.S1.02
Hydrophobic TM5 S 307 5x68 G.H5 L 345 G.H5.16
Van-der-waals TM5 S 307 5x68 G.H5 L 345 G.H5.16
Ionic ICL2 K 220 - G.H5 E 351 G.H5.22
Polar ICL2 K 220 - G.H5 E 351 G.H5.22
Van-der-waals ICL2 K 220 - G.H5 E 351 G.H5.22
Hydrophobic TM6 E 326 6x30 G.H5 L 349 G.H5.20
Van-der-waals TM6 E 326 6x30 G.H5 L 349 G.H5.20
Hydrophobic TM5 V 311 5x72 G.S6 Y 321 G.S6.02
Van-der-waals TM5 V 311 5x72 G.S6 Y 321 G.S6.02
Hydrophobic ICL2 P 217 - G.S3 I 195 G.S3.01
Hydrophobic TM6 T 329 6x33 G.H5 F 352 G.H5.23
Polar ICL2 P 217 - G.H5 N 348 G.H5.19
Polar TM3 A 212 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 212 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 212 3x53 G.H5 N 348 G.H5.19
Polar TM3 R 209 3x50 G.H5 F 352 G.H5.23
Hydrophobic TM3 R 209 3x50 G.H5 F 352 G.H5.23
Van-der-waals TM3 R 209 3x50 G.H5 F 352 G.H5.23
Hydrophobic ICL2 P 217 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 217 - G.H5 I 344 G.H5.15
Hydrophobic TM2 T 138 2x39 G.H5 V 355 G.H5.26
Van-der-waals TM2 T 138 2x39 G.H5 V 355 G.H5.26
Hydrophobic TM5 V 311 5x72 G.H5 F 335 G.H5.06
Van-der-waals TM5 V 311 5x72 G.H5 F 335 G.H5.06
Polar TM6 A 318 6x22 G.h4s6 K 316 G.h4s6.11
Polar ICL2 K 220 - G.H5 N 348 G.H5.19
Hydrophobic ICL2 K 220 - G.H5 N 348 G.H5.19
Van-der-waals ICL2 K 220 - G.H5 N 348 G.H5.19
Hydrophobic TM5 V 311 5x72 G.H5 D 342 G.H5.13
Hydrophobic TM5 V 311 5x72 G.H5 A 338 G.H5.09
Van-der-waals TM5 V 311 5x72 G.H5 A 338 G.H5.09
Polar TM6 S 325 6x29 G.H5 N 353 G.H5.24
Hydrophobic TM6 S 325 6x29 G.H5 N 353 G.H5.24
Van-der-waals TM6 S 325 6x29 G.H5 N 353 G.H5.24
Polar H8 N 391 8x47 G.H5 L 354 G.H5.25
Hydrophobic H8 N 391 8x47 G.H5 L 354 G.H5.25
Van-der-waals H8 N 391 8x47 G.H5 L 354 G.H5.25
Polar TM6 S 325 6x29 G.H5 L 349 G.H5.20
Hydrophobic TM6 A 318 6x22 G.h4s6 E 317 G.h4s6.12
Hydrophobic ICL3 V 314 - G.H4 Q 310 G.H4.16
Van-der-waals ICL3 V 314 - G.H4 Q 310 G.H4.16
Hydrophobic H8 P 392 8x48 G.H5 N 353 G.H5.24
Van-der-waals H8 P 392 8x48 G.H5 N 353 G.H5.24
Polar ICL2 K 220 - G.hns1 R 33 G.hns1.02
Hydrophobic H8 P 392 8x48 G.H5 L 354 G.H5.25
Polar H8 N 393 8x49 G.H5 L 354 G.H5.25
Hydrophobic H8 N 393 8x49 G.H5 L 354 G.H5.25
Van-der-waals H8 N 393 8x49 G.H5 L 354 G.H5.25
Hydrophobic TM3 I 213 3x54 G.H5 L 345 G.H5.16
Van-der-waals TM3 I 213 3x54 G.H5 L 345 G.H5.16
Hydrophobic TM2 I 142 2x43 G.H5 V 355 G.H5.26
Van-der-waals TM2 I 142 2x43 G.H5 V 355 G.H5.26
Polar H8 N 391 8x47 G.H5 V 355 G.H5.26
Hydrophobic H8 N 391 8x47 G.H5 V 355 G.H5.26
Van-der-waals H8 N 391 8x47 G.H5 V 355 G.H5.26
Polar C-term N 410 - G.h4s6 E 317 G.h4s6.12
Polar ICL2 R 218 - G.h2s4 T 220 G.h2s4.05
Van-der-waals ICL2 R 218 - G.h2s4 T 220 G.h2s4.05
Hydrophobic TM7 Y 387 7x53 G.H5 V 355 G.H5.26
Polar ICL3 N 315 - G.h4s6 K 316 G.h4s6.11
Van-der-waals ICL3 V 314 - G.S6 S 322 G.S6.03
Polar ICL2 R 218 - G.hns1 A 32 G.hns1.01
Van-der-waals ICL2 R 218 - G.hns1 A 32 G.hns1.01
Hydrophobic TM6 A 318 6x22 G.h4s6 V 319 G.h4s6.20
Van-der-waals TM6 A 318 6x22 G.h4s6 V 319 G.h4s6.20
Polar TM6 T 329 6x33 G.H5 L 349 G.H5.20
Hydrophobic TM6 T 329 6x33 G.H5 L 349 G.H5.20
Van-der-waals TM6 T 329 6x33 G.H5 L 349 G.H5.20
Polar ICL2 R 218 - G.S1 E 35 G.S1.01
Hydrophobic ICL2 R 218 - G.S1 E 35 G.S1.01
Van-der-waals ICL2 R 218 - G.S1 E 35 G.S1.01
Hydrophobic TM3 A 212 3x53 G.H5 F 352 G.H5.23
Van-der-waals TM3 A 212 3x53 G.H5 F 352 G.H5.23
Polar ICL2 R 218 - G.hns1 R 33 G.hns1.02
Hydrophobic ICL2 R 218 - G.hns1 R 33 G.hns1.02
Van-der-waals ICL2 R 218 - G.hns1 R 33 G.hns1.02
Hydrophobic TM3 D 208 3x49 G.H5 F 352 G.H5.23
Hydrophobic TM2 N 139 2x40 G.H5 V 355 G.H5.26
Van-der-waals TM2 N 139 2x40 G.H5 V 355 G.H5.26
Hydrophobic ICL2 R 218 - G.S1 L 36 G.S1.02
Van-der-waals ICL2 R 218 - G.S1 L 36 G.S1.02
Hydrophobic ICL3 V 314 - G.H4 L 306 G.H4.12
Hydrophobic ICL2 P 216 - G.S3 I 195 G.S3.01
Hydrophobic TM3 I 213 3x54 G.H5 L 349 G.H5.20
Ionic ICL2 E 219 - G.hns1 R 34 G.hns1.03
Hydrophobic TM5 V 304 5x65 G.H5 L 349 G.H5.20
Hydrophobic TM6 R 322 6x26 G.H5 Q 346 G.H5.17
Van-der-waals TM6 R 322 6x26 G.H5 Q 346 G.H5.17
Hydrophobic TM3 I 213 3x54 G.H5 F 352 G.H5.23
Polar TM6 S 325 6x29 G.H5 R 350 G.H5.21
Hydrophobic TM6 L 321 6x25 G.h4s6 E 317 G.h4s6.12
Van-der-waals TM6 L 321 6x25 G.h4s6 E 317 G.h4s6.12
Hydrophobic TM6 R 328 6x32 G.H5 N 353 G.H5.24
Van-der-waals TM6 R 328 6x32 G.H5 N 353 G.H5.24
Polar TM6 T 329 6x33 G.H5 N 353 G.H5.24
Hydrophobic TM6 T 329 6x33 G.H5 N 353 G.H5.24
Van-der-waals TM6 T 329 6x33 G.H5 N 353 G.H5.24
Hydrophobic ICL3 P 313 - G.h4s6 V 319 G.h4s6.20
Van-der-waals ICL3 P 313 - G.h4s6 V 319 G.h4s6.20